Project description
Understanding the relationship between metabolism and circadian rhythms
The circadian clock coordinates physiological processes in response to external cues while also functioning independently through endogenous signals. Succinate, a byproduct of metabolism and the microbiota, is emerging as a biomarker for metabolic dysfunction and cardiovascular risk. Previous research indicates that succinate regulates adipocyte core clock genes via the SUCNR1 receptor. With support from the Marie Skłodowska-Curie Actions programme, the CIRCASUC project will introduce succinate as a key link between metabolism and circadian clocks. The project proposes that succinate may serve as an essential endogenous signal for modulating circadian rhythms. By integrating the succinate/SUCNR1 axis with chronobiology, the project aims to enhance our understanding of the relationship between metabolism and circadian rhythms.
Objective
Our circadian clock controls a wide range of physiological processes to respond to external demands through a fine-tuning coordination between the hypothalamic central clock and the peripheral clocks. Understanding the bidirectional communication and the reliance on external cues that specifically affect these clocks is of paramount importance. Yet, both circadian clocks can function even in the absence of these external signals, highlighting their endogenous nature. This underscores the existence of endogenous signals such as metabolites and other biomolecules that can modulate the circadian clocks. Surprisingly, this aspect remains largely unexplored in current research.
Succinate is both an energetic metabolic product of mitochondrial activity and a byproduct of the microbiota, with critical physiological roles in cellular function at various levels. Furthermore, in the last years, succinate is emerging as a biomarker for early detection of metabolic dysfunction and cardiovascular risk. As a basis for the current proposal, we have recently reported, via an untargeted approach, that succinate regulates core-clock genes in adipocytes via its cognate receptor, SUCNR1. Thus, building upon our previous studies, we propose that succinate may serve as a pivotal endogenous signal capable of modulating the circadian clocks.
Within the framework of this project, we present for the first time the concept of succinate as a link between metabolism and circadian clocks. To accomplish our goals, we will employ the complementary expertise between Dr Fernández-Veledo (supervisor and renowned expert in the succinate/SUCNR1 axis) and Dr Ribas (candidate and expert in chronobiology). By merging these two fields, we aim to integrate the notion of temporality into the succinate/SUCNR1 axis, and advance our understanding of the intricate relationship between metabolism and circadian rhythms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
43003 Tarragona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.