Project description
C(sp3)-C bond formation via low-valent bismuth catalysis and electrochemistry
Carbon-carbon (C-C) bonds are the backbone of organic molecules and are therefore essential to organic chemistry and the synthesis of innumerable organic molecules, both known and predicted/desired. However, forming these bonds can be challenging; C(sp3) carboxylation and C(sp3)-C(sp3) coupling reactions are among the transformations that remain difficult to achieve, even with transition metal catalysis. With the support of the Marie Skłodowska-Curie Actions programme, the Bi-echem project aims to enable sustainable C-C bond formation by merging low-valent bismuth catalysis with electrochemistry. This will be the first systematic investigation of electrocatalytic organobismuth frameworks for the synthesis of organic molecules, with a focus on C(sp3) carboxylation and C(sp3)-C(sp3) coupling reactions.
Objective
The proposed work involves merging low-valent bismuth catalysis with electrochemistry to unlock eminently sustainable methods for C-C bond formation. The research outlined herein would constitute the first systematic foray into electrocatalytic organobismuth manifolds for the synthesis of organic molecules.
Well-defined monomeric Bi(I) pincer complexes have recently been used to activate redox-active esters and alkyl halides via 1-electron and 2-electron pathways, respectively. In the first section, we propose a systematic electrochemical characterization of several N,C,N-Bi(III) pincer complexes, with particular emphasis on identifying the reversibility and potential of distinct redox states accessible by each complex. The cathodic reduction of Bi(III) species to their Bi(I) counterparts will also be performed in the presence of alkyl electrophiles to afford Bi(III)-alkyl species. The insights obtained from these foundational studies will be applied in the context of developing electrocatalytic manifolds for the C(sp3) carboxylation and C(sp3)-C(sp3) coupling reactions, two transformations that remain challenging even in the context of transition metal catalysis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural scienceschemical scienceselectrochemistry
- natural scienceschemical sciencesinorganic chemistrypost-transition metals
- natural scienceschemical sciencescatalysis
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Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
45470 Muelheim An Der Ruhr
Germany