Objective
T cell acute lymphoblastic leukaemia (T-ALL) is a rare disease that affects around 10-13 individuals in one million and affects pediatric and adult patients. High-dose chemotherapy is an adequate therapeutic treatment for most patients, however 10-20% of patients relapse and will require a bone marrow transplantation as a unique therapeutic window. T-ALL is a very aggressive disease and the rapidness in the response is crucial, however, one problem is that we cannot predict which patients will relapse. Several studies have been done to understand the origin of relapse, and there is evidence for several strategies for leukemia evolution: a) the relapse clone already exists at the time of diagnosis and is selected through treatment or b) treatment provides new mutations that will generate the relapse clone. Predicting the evolution of leukemic clones after chemotherapy pressure and understanding the specific mechanisms contributing to chemotherapy-resistant cell populations' appearance is necessary to improve cancer treatment. In our proposal, we wish to find feasible and clinically applicable ways to detect the earlier-stage clones that become resistant to chemotherapy. We wish to apply multiple approaches to better understand the specific clones like single-cell sequencing of primary T-ALL samples at diagnosis and relapse, and most importantly, compare their evolution with or without chemotherapy treatment through 2D, 3D culture and the current pdx in vivo model of leukaemia. Application of the 3D cell culture technique to T-ALL clonal evolution may represent a major scientific discovery to be used for different purposes focusing on disease modelling and relapse clone study. Our research will be pursued to optimize a method mimicking T-ALL in vitro, characterize the cells (and factors) causing the relapse, and use this information to identify new therapeutic options.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine oncology leukemia
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
41013 Sevilla
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.