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Deciphering mineralogical and compositional properties of kidney stones: Implications for formation mechanism and potential treatments

Project description

A closer look at kidney stone formation

Kidney stone disease is a serious and increasingly common health problem worldwide, with its prevalence linked to factors such as diet, environmental conditions, and medical issues like diabetes. The exact relationship between kidney stone formation and these factors is poorly understood, particularly how stone composition interacts with bodily fluids like urine and blood. This gap in knowledge hampers effective diagnosis and treatment. Additionally, the role of organic compounds in stone growth and dissolution remains unclear. With the support of the Marie Skłodowska-Curie Actions programme, the MiKidSton project will study a wide range of kidney stone samples. By analysing the stones from the macro to nanoscale, the project aims to identify connections to risk factors.

Objective

Kidney stone disease is a vital health problem with a significant increase in prevalence worldwide. It is known that kidney stone formation is affected by medical conditions (i.e. diabetes), environmental factors, dietary habits, and gender, although the relationship between the stone mineralogical and chemical properties (e.g. crystal structure, elemental composition, etc.) to the urine and blood parameters are still unclear. Notably, there is limited information on how the kidney stone mineral phase is influenced by the organic compounds of body fluids during growth and dissolution. Likewise, the kidney stone isotope composition will be recorded during its formation, and subsequently can be used as an indicator of dietary habits, environmental factors, and identifying underlying diseases (e.g. diabetes, osteoporosis). MiKidSton aims to perform a systematic study, from macro- to nanoscale, on a large array of different types of kidney stone samples, to assess: i) the influence of the body fluid (urine and blood) parameters, as recorded in patients, on the characteristics of kidney stone biomineral phases, ii) the relationship of the chemical/isotope composition of kidney stones to their structure, and risk factors (e.g. diet, environment, diabetes, etc.), and iii) the controlling factors for stone formation and dissolution. These objectives will be achieved combining applicant’s expertise and that of PIs, from the two host institutions, on mineralogical and isotope analyses. The outcomes will shed light on connection between kidney stone structure, composition, growth and dissolution with physiological parameters for patients with urolithiasis, with important implications for accurate diagnosis and effective treatment strategies. Finally, MiKidSton findings will have important implications for future pathological biomineral investigation using cutting-edge techniques and, most importantly, for the study of other stone-related human diseases (e.g. gallstones).

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HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2023-PF-01

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Coordinator

UNIVERSIDAD DE OVIEDO
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 317 205,60
Address
CALLE SAN FRANCISCO 3
33003 OVIEDO
Spain

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Region
Noroeste Principado de Asturias Asturias
Activity type
Higher or Secondary Education Establishments
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Total cost

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Partners (2)

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