Project description
A functional study of short-term and long-term memory acquisition
Memories are of inestimable importance to our well-being – and their loss, or inability to form new ones, has severe negative impacts on individuals and their families. Short-term memories rely on the hippocampus and some of these become long-term memories that are dependent on the cortex. However, it is not known how certain memories move into long-term storage while others do not. With the support of the Marie Skłodowska-Curie Actions programme, the REMGRAM project aims to explore these two regions during memory acquisition by using tagging and light activation of cells to study calcium signalling with an innovative optogenetic tool. Its unique temporal precision and differential labelling of cells will be key.
Objective
Every day we form memories based on experience. These memories undergo a selective process, during which some become long-lasting memories while others fade away.Memory age can be distinguished based on the neuronal systems engaged during different stages: recently acquired detailed memories rely on the hippocampus (especially CA1),while remotely acquired, more generalised memories depend on cortical activation(specifically the anterior cingulate cortex, aCC). However, our understanding of how certain information from the original event is selected to migrate from one region to the other, while other is lost, remains limited.
We aim to explore whether these two regions attend to different information during memory acquisition. To accomplish this, we will employ FliCRE, an innovative optogenetic tool that offers precise temporal control over the tagging and manipulation of cells through both calcium signalling and light activation. This groundbreaking technology allows us to attain an unprecedented level of temporal precision, enabling differential labelling of cells that encode distinct information, such as when a mouse is exploring an environment versus experiencing a footshock or freezing.
By tagging and manipulating these diverse populations in CA1 and aCC, we will track their recruitment at different time points. This investigation seeks to shed light on why memory age influences our perception of the original experience differently. By understanding the underlying neuronal mechanisms, we may find ways to reverse this effect, offering a potential approach to help treat maladaptive memories. Our research holds promise in unravelling the complexities of consolidation and its implications for memory therapies.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology cognitive neuroscience
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.