Objective
MicroRNAs (miRNAs) are a class of highly conserved small non-coding RNAs that regulate the expression of most protein coding genes. MiRNAs have been extensively studied, not only to understand their molecular function but also due to their potential as therapeutic and diagnostic tools. Most current studies rely on small RNA sequencing (sRNA-seq), recently extended to single cells, because it allows to measure all miRNAs present in a sample even at low input amounts. However, state-of-the-art statistical analysis of sRNA-seq data is still performed using standard mRNA-seq software. This is inappropriate because miRNA counts violate several assumptions of these methods. In extreme cases, upregulated miRNAs will falsely seem down-/upregulated because of technical effects. Technical bias is even more severe in low input applications, e.g. single-cell, so decreasing the RNA input lowers quantification accuracy. By developing statistical methods specifically tailored to model sRNA-seq complexities, miRAQEL aims to dramatically improve the accuracy of miRNA quantification through sRNA-seq, contributing to solve challenges in the field. Appropriate statistical methodology is urgently needed to fully elucidate the role miRNAs play in many diseases and improve their biomarker potential.
The fellow will receive specialized training in standard single-cell RNA-seq and statistical analysis of miRNA data from a leading research team in the field. In turn, he will bring his pipeline development and miRNA genomics expertise to implement and evaluate sRNA-seq modelling software using ground truth data and simulations. A placement will ensure transfer of this knowledge to an European start-up. The emerging unique skill set will provide him with a privileged interdisciplinary view that he can leverage to kick-start an independent academic career in the analysis of small RNA molecules at the single cell level, getting ahead in a field that is expected to develop in the coming years.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
18071 GRANADA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.