Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.

Información del proyecto

EMPATIC

Identificador del acuerdo de subvención: 101158332

DOI

10.3030/101158332

Proyecto cerrado

Fecha de la firma de la CE 30 Abril 2024

Fecha de inicio 1 Julio 2024

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• European Research Council (ERC)

Coste total

Sin datos

Aportación de la UE

€ 150 000,00

Coordinado por

POLITECNICO DI TORINO
Italy

Periodic Reporting for period 1 - EMPATIC (Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.)

Período documentado: 2024-07-01 hasta 2025-12-31

Resumen del contexto y de los objetivos generales del proyecto

Cardiovascular diseases continue to represent a major global health burden, highlighting the urgent need for more effective and safer therapeutic strategies. A critical limitation in current biomedical research lies in the insufficient predictive power of traditional preclinical models, which often fail to replicate the structural, mechanical, and functional complexity of human cardiac tissue. Advances in bioengineering have demonstrated the potential of three-dimensional (3D) in vitro cardiac models to better reproduce key aspects of human heart physiology, offering new opportunities for more reliable translational research.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Building on recent progress in cardiac tissue engineering, EMPATIC project developed an innovative platform designed to support the generation of physiologically relevant human cardiac tissue in vitro. The system combines advanced culture environment with integrated functional monitoring capabilities. This approach enables controlled cellular organization and functional assessment in a scalable and user-friendly configuration, facilitating broader adoption in research and preclinical settings.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

By contributing to the development of more human-relevant in vitro cardiac models, EMPATIC supports the advancement of New Approach Methodologies (NAMs) and promotes a transition toward more predictive, ethical, and sustainable biomedical research practices. In the long term, the platform has the potential to enhance drug development efficiency, improve safety evaluation, and reduce reliance on animal experimentation, ultimately accelerating innovation in cardiovascular and regenerative medicine.

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