Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.

Informacje na temat projektu

EMPATIC

Identyfikator umowy o grant: 101158332

DOI

10.3030/101158332

Projekt został zamknięty

Data podpisania przez KE 30 Kwietnia 2024

Data rozpoczęcia 1 Lipca 2024

Data zakończenia 31 Grudnia 2025

Finansowanie w ramach

• European Research Council (ERC)

Koszt całkowity

Brak danych

Wkład UE

€ 150 000,00

Koordynowany przez

POLITECNICO DI TORINO
Italy

Periodic Reporting for period 1 - EMPATIC (Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.)

Okres sprawozdawczy: 2024-07-01 do 2025-12-31

Podsumowanie kontekstu i ogólnych celów projektu

Cardiovascular diseases continue to represent a major global health burden, highlighting the urgent need for more effective and safer therapeutic strategies. A critical limitation in current biomedical research lies in the insufficient predictive power of traditional preclinical models, which often fail to replicate the structural, mechanical, and functional complexity of human cardiac tissue. Advances in bioengineering have demonstrated the potential of three-dimensional (3D) in vitro cardiac models to better reproduce key aspects of human heart physiology, offering new opportunities for more reliable translational research.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

Building on recent progress in cardiac tissue engineering, EMPATIC project developed an innovative platform designed to support the generation of physiologically relevant human cardiac tissue in vitro. The system combines advanced culture environment with integrated functional monitoring capabilities. This approach enables controlled cellular organization and functional assessment in a scalable and user-friendly configuration, facilitating broader adoption in research and preclinical settings.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

By contributing to the development of more human-relevant in vitro cardiac models, EMPATIC supports the advancement of New Approach Methodologies (NAMs) and promotes a transition toward more predictive, ethical, and sustainable biomedical research practices. In the long term, the platform has the potential to enhance drug development efficiency, improve safety evaluation, and reduce reliance on animal experimentation, ultimately accelerating innovation in cardiovascular and regenerative medicine.

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