Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.

Informazioni relative al progetto

EMPATIC

ID dell’accordo di sovvenzione: 101158332

DOI

10.3030/101158332

Progetto chiuso

Data della firma CE 30 Aprile 2024

Data di avvio 1 Luglio 2024

Data di completamento 31 Dicembre 2025

Finanziato da

• European Research Council (ERC)

Costo totale

Nessun dato

Contributo UE

€ 150 000,00

Coordinato da

POLITECNICO DI TORINO
Italy

Periodic Reporting for period 1 - EMPATIC (Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.)

Periodo di rendicontazione: 2024-07-01 al 2025-12-31

Sintesi del contesto e degli obiettivi generali del progetto

Cardiovascular diseases continue to represent a major global health burden, highlighting the urgent need for more effective and safer therapeutic strategies. A critical limitation in current biomedical research lies in the insufficient predictive power of traditional preclinical models, which often fail to replicate the structural, mechanical, and functional complexity of human cardiac tissue. Advances in bioengineering have demonstrated the potential of three-dimensional (3D) in vitro cardiac models to better reproduce key aspects of human heart physiology, offering new opportunities for more reliable translational research.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

Building on recent progress in cardiac tissue engineering, EMPATIC project developed an innovative platform designed to support the generation of physiologically relevant human cardiac tissue in vitro. The system combines advanced culture environment with integrated functional monitoring capabilities. This approach enables controlled cellular organization and functional assessment in a scalable and user-friendly configuration, facilitating broader adoption in research and preclinical settings.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

By contributing to the development of more human-relevant in vitro cardiac models, EMPATIC supports the advancement of New Approach Methodologies (NAMs) and promotes a transition toward more predictive, ethical, and sustainable biomedical research practices. In the long term, the platform has the potential to enhance drug development efficiency, improve safety evaluation, and reduce reliance on animal experimentation, ultimately accelerating innovation in cardiovascular and regenerative medicine.

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