Twinning Approach for Computational MRI Technology and Innovation EXcellence in Turkey

Información del proyecto

TACTIX

Identificador del acuerdo de subvención: 101159624

DOI

10.3030/101159624

Fecha de la firma de la CE 4 Abril 2024

Fecha de inicio 1 Junio 2024

Fecha de finalización 31 Mayo 2027

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

Sin datos

Aportación de la UE

€ 1 491 029,55

Coordinado por

BOGAZICI UNIVERSITESI
Türkiye

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (1)

BBB-ASL processing pipeline

The ExploreASL pipeline for data processing of BBB-ASL data will be adapted by AUMC to process data from MS patients. Specifically, this involves MS lesion segmentation, lesion-specific partial volume correction, and adding the CSF leakage model to the image processing (first version ✔D4.2).

Websites, patent fillings, videos etc. (5)

Summer schools 1

Three summer schools (✔D3.4-D3.6) will be held at the location of the organizer. The first will be organized by BOUN (✔D3.4), focusing on MRI basics.

Five courses prepared

MRI_R&D Program courses will be created by senior researchers at BOUN with the support of MEVIS and AUMC. The courses will be designed to be delivered as 3 hours/week in 14 weeks of a semester. Slide presentations and recorded videos will be prepared for the first five lectures (✔D2.1).

Information days 1

First of the BOUN information days (✔D6.6) will be organized to update all stakeholders on our research progress and to inform of the new teaching content. These will be single-day programs for up to 50 registered attendees from academia, industry, and policymakers. There will be a series of talks about the progress of the project and scientific results, with a round-table discussion about the future of Turkish graduate education and research. A parallel program will be in place and open for the general public with non-specialist presentations about MS, progress in MR imaging of MS, and TACTIX, accompanied by posters, where the public can interact with junior researchers. Brochures about the project and the MRI R&D program will be distributed.

Layman articles and podcasts 1

The general public and MS patients will be informed about our research project through three podcasts and three articles written in lay language. First podcast and layman article (✔D6.3)

Winter workshops 1

Three winter workshops (✔D3.1-D3.3) will be organized, one at each partner institute. The first workshop at BOUN will cover clinical concepts including MS formation, and MRI and imaging biomarkers of MS.

Publicaciones

Conference proceedings (11)

Machine Learning-Based IDH Mutational Subgroup Classification in Gliomas Using Cerebral Blood Flow and BBB-ASL Exchange Times.

Autores: Turhan G, Cetin AI, Cur OY, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam N-J, Mutsaerts H-J, Danyeli AE, Ozduman K, Eickel K, Keil V, Günther M, Petr J, Dincer A, Ozturk-Isik E.
Publicado en: Book of Abstracts ESMRMB 2025 Online 41st Annual Scientific Meeting 8–11 October 2025., Edición 47591, 2025
Editor: ESMRMB

Longitudinal atrophy measures in MS differ between scanners: implications for trials and clinical implementation.

Autores: van Nederpelt, D., Brouwer, I., Bos, L., Strijbis, E., Moraal, B., Jasperse, B., Mutsaerts, H.-J., Petr, J., Killestein, J., Schoonheim, M., Barkhof, F., Kuijer, J., Vrenken, H.
Publicado en: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Edición P1401, 2025
Editor: ECTRIMS

Harmonizing T1w MRI scans with HACA3 reduces between-scanner volume differences while preserving sensitivity to MS-related atrophy.

Autores: van Nederpelt, D., Hays, S., Brouwer, I., Strijbis, E., Zuo, L., Moraal, B., Jasperse, B., Mutsaerts, H.-J., Petr, J., Killestein, J., Schoonheim, M., Barkhof, F., Kuijer, J., Vrenken, H.
Publicado en: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Edición P708, 2025
Editor: ECTRIMS

Application of BBB-ASL in MS: Initial Experience.

Autores: Cetin AI, Turhan G, Van Nederpelt DR, Emekli AS, Mahroo A, Padrela BE, Konstandin S, Honkiss DC, Breutigam N-J, Keil V, Barkhof F, Eickel K, Mutsaerts H-J, Günther M, Kaya D, Dincer A, Petr J, Ozturk-Isik E.
Publicado en: 2025
Editor: European Society for Magnetic Resonance in Medicine and Biology.

Application of BBB-ASL in MS: Initial Experience.

Autores: Cetin AI, Turhan G, Van Nederpelt DR, Emekli AS, Mahroo A, Padrela BE, Konstandin S, Honkiss DC, Breutigam N-J, Keil V, Barkhof F, Eickel K, Mutsaerts H-J, Günther M, Kaya D, Dincer A, Petr J, Ozturk-Isik E.
Publicado en: Book of Abstracts, Edición 48022, 2025
Editor: uropean Society for Magnetic Resonance in Medicine and Biology

Comparing One-Stage and Two-Stage Model Fitting Approaches in Multi-TE ASL for Blood-Brain Barrier Permeability Assessment.

Autores: Mahroo A, Eickel K, Günther M.
Publicado en: International Society for Magnetic Resonance in Medicine 2025 Proceedings, Edición s4775, 2025
Editor: ISMRM

Intracranial volume loss and skull thickening in metachromatic leukodystrophy and multiple sclerosis.

Autores: Vorst, G., Wolf, N., van Nederpelt, D., Barkhof, F., van der Knaap, M., Schoonheim, M., Strijbis, E., Pouwels, P.
Publicado en: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Edición P1397, 2025
Editor: ECTRIMS

Identifying MS subtypes using MRI-based machine learning.

Autores: Bianchi, A., Cortese, R., Battaglini, M., Eshaghi, A., Battaglia, G., Luchetti, L., Sforazzini, F., Gentile, G., Cacciante, F., Leoncini, M., Barkhof, F., Bellenberg, B., Bisecco, A., Bodini, B., Cagol, A., Calabrese, M., Calvi, A., Colato, E., et al.
Publicado en: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Edición O056, 2025
Editor: ECTRIMS

Perfusion and Time of Exchange Measurements in IDH Mutational Subgroups of Gliomas Using BBB-ASL.

Autores: Turhan G, Çetin Aİ, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam NJ, Keil V, Danyeli AE, Ozduman K, Eickel K, Mutsaerts HJMM, Günther M, Petr J, Dincer A, Ozturk-Isik E.
Publicado en: International Society for Magnetic Resonance in Medicine 2025 Proceedings, Edición 880, 2025
Editor: International Society for Magnetic Resonance in Medicine.

The role of network connectivity and transcriptomic vulnerability in shaping gray matter atrophy in multiple sclerosis.

Autores: Barrantes-Cepas, M., Steenwijk, M. D., van Nederpelt, D., Koubiyr, I., Tranfa, M., Lorenzini, L., Vrenken, H., Killestein, J., Strijbis, E., Barkhof, F., Schoonheim, M., Pontillo, G.
Publicado en: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Edición P673, 2025
Editor: ECTRIMS

Machine Learning-Based IDH Mutational Subgroup Classification in Gliomas Using Cerebral Blood Flow and BBB-ASL Exchange Times.

Autores: Turhan G, Cetin AI, Cur OY, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam N-J, Mutsaerts H-J, Danyeli AE, Ozduman K, Eickel K, Keil V, Günther M, Petr J, Dincer A, Ozturk-Isik E.
Publicado en: 2025
Editor: European Society for Magnetic Resonance in Medicine and Biology.

Peer reviewed articles (4)

Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL

Autores: Yeva Prysiazhniuk, Rui Duarte Armindo, Sasha Alexander, Michael Moseley, Kristen W. Yeom, Jakub Otáhal, Martin Kynčl, Elizabeth Tong, Jan Petr, Moss Y. Zhao, Gary K. Steinberg
Publicado en: Neuroradiology, Edición 67, 2025, ISSN 0028-3940
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S00234-025-03794-9

Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden

Autores: Beatriz E. Padrela, Sandra Tecelão, Bjørn-Eivind Kirsebom, Oliver Geier, Mario Tranfa, Federico Masserini, Markus H. Sneve, Maksim Slivka, Emilie Sogn Falch, Lene Pålhaugen, Amnah Mahroo, Klaus Eickel, David L. Thomas, Matthias Günther, Per Selnes, Atle Bjørnerud, Kristine B. Walhovd, Anders M. Fjell, Frederik Barkhof, Jan Petr, Tormod Fladby, Henk J.M.M. Mutsaerts
Publicado en: NeuroImage: Clinical, Edición 49, 2026, ISSN 2213-1582
Editor: Elsevier BV
DOI: 10.1016/J.NICL.2025.103926

Comparative evaluation of single- and multi-delay arterial spin labeling MRI in preterm neonates

Autores: Yeva Prysiazhniuk, Sasha Alexander, Rui Duarte Armindo, Elizabeth Tong, Kristen W Yeom, Jakub Otáhal, Martin Kynčl, Michael Moseley, Jan Petr, Moss Y Zhao, Gary K Steinberg
Publicado en: NeuroImage, Edición 321, 2025, ISSN 1053-8119
Editor: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2025.121511

Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age

Autores: Mathijs B.J. Dijsselhof, Candace Moore, Saba Amiri, Mervin Tee, Saima Hilal, Christopher Chen, Bert-Jan H. van den Born, Wibeke Nordhøy, Ole A. Andreassen, Lars T. Westlye, Nishi Chaturvedi, Alun D. Hughes, David M. Cash, Jonathan M. Schott, Carole H. Sudre, Frederik Barkhof, Joost P.A. Kuijer, Francesca Biondo, James H. Cole, Henk J.M.M. Mutsaerts, Jan Petr
Publicado en: Imaging Neuroscience, Edición 3, 2025, ISSN 2837-6056
Editor: MIT Press
DOI: 10.1162/IMAG.A.964