Twinning Approach for Computational MRI Technology and Innovation EXcellence in Turkey

Informations projet

TACTIX

N° de convention de subvention: 101159624

DOI

10.3030/101159624

Date de signature de la CE 4 Avril 2024

Date de début 1 Juin 2024

Date de fin 31 Mai 2027

Financé au titre de

• Widening participation and spreading excellence

Coût total

Aucune donnée

Contribution de l’UE

€ 1 491 029,55

Coordonné par

BOGAZICI UNIVERSITESI
Türkiye

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Other (1)

BBB-ASL processing pipeline

The ExploreASL pipeline for data processing of BBB-ASL data will be adapted by AUMC to process data from MS patients. Specifically, this involves MS lesion segmentation, lesion-specific partial volume correction, and adding the CSF leakage model to the image processing (first version ✔D4.2).

Websites, patent fillings, videos etc. (5)

Summer schools 1

Three summer schools (✔D3.4-D3.6) will be held at the location of the organizer. The first will be organized by BOUN (✔D3.4), focusing on MRI basics.

Five courses prepared

MRI_R&D Program courses will be created by senior researchers at BOUN with the support of MEVIS and AUMC. The courses will be designed to be delivered as 3 hours/week in 14 weeks of a semester. Slide presentations and recorded videos will be prepared for the first five lectures (✔D2.1).

Information days 1

First of the BOUN information days (✔D6.6) will be organized to update all stakeholders on our research progress and to inform of the new teaching content. These will be single-day programs for up to 50 registered attendees from academia, industry, and policymakers. There will be a series of talks about the progress of the project and scientific results, with a round-table discussion about the future of Turkish graduate education and research. A parallel program will be in place and open for the general public with non-specialist presentations about MS, progress in MR imaging of MS, and TACTIX, accompanied by posters, where the public can interact with junior researchers. Brochures about the project and the MRI R&D program will be distributed.

Layman articles and podcasts 1

The general public and MS patients will be informed about our research project through three podcasts and three articles written in lay language. First podcast and layman article (✔D6.3)

Winter workshops 1

Three winter workshops (✔D3.1-D3.3) will be organized, one at each partner institute. The first workshop at BOUN will cover clinical concepts including MS formation, and MRI and imaging biomarkers of MS.

Publications

Conference proceedings (11)

Machine Learning-Based IDH Mutational Subgroup Classification in Gliomas Using Cerebral Blood Flow and BBB-ASL Exchange Times.

Auteurs: Turhan G, Cetin AI, Cur OY, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam N-J, Mutsaerts H-J, Danyeli AE, Ozduman K, Eickel K, Keil V, Günther M, Petr J, Dincer A, Ozturk-Isik E.
Publié dans: Book of Abstracts ESMRMB 2025 Online 41st Annual Scientific Meeting 8–11 October 2025., Numéro 47591, 2025
Éditeur: ESMRMB

Longitudinal atrophy measures in MS differ between scanners: implications for trials and clinical implementation.

Auteurs: van Nederpelt, D., Brouwer, I., Bos, L., Strijbis, E., Moraal, B., Jasperse, B., Mutsaerts, H.-J., Petr, J., Killestein, J., Schoonheim, M., Barkhof, F., Kuijer, J., Vrenken, H.
Publié dans: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Numéro P1401, 2025
Éditeur: ECTRIMS

Harmonizing T1w MRI scans with HACA3 reduces between-scanner volume differences while preserving sensitivity to MS-related atrophy.

Auteurs: van Nederpelt, D., Hays, S., Brouwer, I., Strijbis, E., Zuo, L., Moraal, B., Jasperse, B., Mutsaerts, H.-J., Petr, J., Killestein, J., Schoonheim, M., Barkhof, F., Kuijer, J., Vrenken, H.
Publié dans: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Numéro P708, 2025
Éditeur: ECTRIMS

Application of BBB-ASL in MS: Initial Experience.

Auteurs: Cetin AI, Turhan G, Van Nederpelt DR, Emekli AS, Mahroo A, Padrela BE, Konstandin S, Honkiss DC, Breutigam N-J, Keil V, Barkhof F, Eickel K, Mutsaerts H-J, Günther M, Kaya D, Dincer A, Petr J, Ozturk-Isik E.
Publié dans: 2025
Éditeur: European Society for Magnetic Resonance in Medicine and Biology.

Application of BBB-ASL in MS: Initial Experience.

Auteurs: Cetin AI, Turhan G, Van Nederpelt DR, Emekli AS, Mahroo A, Padrela BE, Konstandin S, Honkiss DC, Breutigam N-J, Keil V, Barkhof F, Eickel K, Mutsaerts H-J, Günther M, Kaya D, Dincer A, Petr J, Ozturk-Isik E.
Publié dans: Book of Abstracts, Numéro 48022, 2025
Éditeur: uropean Society for Magnetic Resonance in Medicine and Biology

Comparing One-Stage and Two-Stage Model Fitting Approaches in Multi-TE ASL for Blood-Brain Barrier Permeability Assessment.

Auteurs: Mahroo A, Eickel K, Günther M.
Publié dans: International Society for Magnetic Resonance in Medicine 2025 Proceedings, Numéro s4775, 2025
Éditeur: ISMRM

Intracranial volume loss and skull thickening in metachromatic leukodystrophy and multiple sclerosis.

Auteurs: Vorst, G., Wolf, N., van Nederpelt, D., Barkhof, F., van der Knaap, M., Schoonheim, M., Strijbis, E., Pouwels, P.
Publié dans: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Numéro P1397, 2025
Éditeur: ECTRIMS

Identifying MS subtypes using MRI-based machine learning.

Auteurs: Bianchi, A., Cortese, R., Battaglini, M., Eshaghi, A., Battaglia, G., Luchetti, L., Sforazzini, F., Gentile, G., Cacciante, F., Leoncini, M., Barkhof, F., Bellenberg, B., Bisecco, A., Bodini, B., Cagol, A., Calabrese, M., Calvi, A., Colato, E., et al.
Publié dans: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Numéro O056, 2025
Éditeur: ECTRIMS

Perfusion and Time of Exchange Measurements in IDH Mutational Subgroups of Gliomas Using BBB-ASL.

Auteurs: Turhan G, Çetin Aİ, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam NJ, Keil V, Danyeli AE, Ozduman K, Eickel K, Mutsaerts HJMM, Günther M, Petr J, Dincer A, Ozturk-Isik E.
Publié dans: International Society for Magnetic Resonance in Medicine 2025 Proceedings, Numéro 880, 2025
Éditeur: International Society for Magnetic Resonance in Medicine.

The role of network connectivity and transcriptomic vulnerability in shaping gray matter atrophy in multiple sclerosis.

Auteurs: Barrantes-Cepas, M., Steenwijk, M. D., van Nederpelt, D., Koubiyr, I., Tranfa, M., Lorenzini, L., Vrenken, H., Killestein, J., Strijbis, E., Barkhof, F., Schoonheim, M., Pontillo, G.
Publié dans: Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Numéro P673, 2025
Éditeur: ECTRIMS

Machine Learning-Based IDH Mutational Subgroup Classification in Gliomas Using Cerebral Blood Flow and BBB-ASL Exchange Times.

Auteurs: Turhan G, Cetin AI, Cur OY, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam N-J, Mutsaerts H-J, Danyeli AE, Ozduman K, Eickel K, Keil V, Günther M, Petr J, Dincer A, Ozturk-Isik E.
Publié dans: 2025
Éditeur: European Society for Magnetic Resonance in Medicine and Biology.

Peer reviewed articles (4)

Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL

Auteurs: Yeva Prysiazhniuk, Rui Duarte Armindo, Sasha Alexander, Michael Moseley, Kristen W. Yeom, Jakub Otáhal, Martin Kynčl, Elizabeth Tong, Jan Petr, Moss Y. Zhao, Gary K. Steinberg
Publié dans: Neuroradiology, Numéro 67, 2025, ISSN 0028-3940
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00234-025-03794-9

Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden

Auteurs: Beatriz E. Padrela, Sandra Tecelão, Bjørn-Eivind Kirsebom, Oliver Geier, Mario Tranfa, Federico Masserini, Markus H. Sneve, Maksim Slivka, Emilie Sogn Falch, Lene Pålhaugen, Amnah Mahroo, Klaus Eickel, David L. Thomas, Matthias Günther, Per Selnes, Atle Bjørnerud, Kristine B. Walhovd, Anders M. Fjell, Frederik Barkhof, Jan Petr, Tormod Fladby, Henk J.M.M. Mutsaerts
Publié dans: NeuroImage: Clinical, Numéro 49, 2026, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1016/J.NICL.2025.103926

Comparative evaluation of single- and multi-delay arterial spin labeling MRI in preterm neonates

Auteurs: Yeva Prysiazhniuk, Sasha Alexander, Rui Duarte Armindo, Elizabeth Tong, Kristen W Yeom, Jakub Otáhal, Martin Kynčl, Michael Moseley, Jan Petr, Moss Y Zhao, Gary K Steinberg
Publié dans: NeuroImage, Numéro 321, 2025, ISSN 1053-8119
Éditeur: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2025.121511

Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age

Auteurs: Mathijs B.J. Dijsselhof, Candace Moore, Saba Amiri, Mervin Tee, Saima Hilal, Christopher Chen, Bert-Jan H. van den Born, Wibeke Nordhøy, Ole A. Andreassen, Lars T. Westlye, Nishi Chaturvedi, Alun D. Hughes, David M. Cash, Jonathan M. Schott, Carole H. Sudre, Frederik Barkhof, Joost P.A. Kuijer, Francesca Biondo, James H. Cole, Henk J.M.M. Mutsaerts, Jan Petr
Publié dans: Imaging Neuroscience, Numéro 3, 2025, ISSN 2837-6056
Éditeur: MIT Press
DOI: 10.1162/IMAG.A.964