Project description
The role of sex in traumatic brain injury
Traumatic brain injury (TBI) affects 30 million women annually. Although women are more susceptible than men in experiencing more brain damage under low impact forces, they are underrepresented in TBI research, particularly regarding sex-specific biomechanics. Moreover, current computational brain models have been developed using male-only data and fail to accurately represent female TBI due to differences in neuroanatomy. The ERC-funded brainsex project aims to investigate the role of sex in TBI biomechanics and develop models that incorporate sex-specific anatomical differences. This will improve predictions of TBI with respect to brain and cerebrovascular tissue damage in men and women.
Objective
Traumatic brain injury (TBI) is a multi-anatomical-scale mechanical injury affecting 30 million women globally each year. brainsex will focus on the sex specific biomechanics of TBI in the elderly population motivated by the highest reported incidence of TBI in people over 75 years old. Furthermore, in the elderly population women account for more TBIs than men. However, women remain underrepresented in TBI research. Finite element brain models (FEBMs) have played a major role in improving our understanding of TBI. However, current FEBMs have been developed using male-only data and cannot accurately model female TBI due to the distinct sex specific neuroanatomies. I will embark on frontier research to test the hypothesis that TBI biomechanics are sex specific due to the multiscale sex specific neuroanatomy, causing damage to brain tissue, cerebral vasculature, and neurons under lower impact forces in women compared to men. To realize this ambitious goal, my team and I will develop ground-breaking sex specific FEBMs incorporating the multiscale sex specific neuroanatomy and constitutive damage properties of brain tissue and cerebral vasculature providing more accurate predictions of TBI from high energy head impacts. We will develop novel experimental technologies to characterise the constitutive damage properties of brain and cerebrovascular tissue (Aim 1), and neurons (Aim 2) under conditions required to model brain deformation during TBI. This data will be used to develop the first ever microstructure-informed constitutive damage model for brain tissue (Aim 2). This model combined with the FEBMs will revolutionise TBI biomechanics (Aim 3). brainsex will open new research horizons for biomechanics research focussing on the important role sex plays in tissue biomechanics. brainsex will deliver a breakthrough in our understanding of TBI biomechanics by delineating the sex dependent mechanical behaviour of brain tissue and cerebral vasculature during head impacts.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-STG
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4 DUBLIN
Ireland
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