Obiettivo
In plants, genetic material is stored in the nucleus and the two cytoplasmic organelles: plastids and mitochondria. While both the nuclear and cytoplasmic genomes are essential for plant survival, the inheritance of these genomes is subject to different sets of rules.
Cytoplasmic inheritance differs from nuclear inheritance through two unique phenomena: uniparental inheritance and vegetative segregation. Despite extensive research efforts, the molecular basis of uniparental inheritance and vegetative segregation remain elusive. A major challenge in unraveling the mechanisms is the lack of methodologies. Excitingly, recent advancements in cytoplasmic genome engineering have provided me with a unique opportunity to develop feasible approaches for exploring this crucial area of biology.
The ultimate goal of this project is to achieve a comprehensive understanding of cytoplasmic inheritance, which will, in turn, enable us to control the plastid and mitochondrial inheritance. To attain this ambitious goal, we will pursue three specific aims: (1) Identifying the factors that govern maternal inheritance, (2) Promoting the selective transmission of cytoplasmic genomes, and (3) Investigating the molecular basis of vegetative segregation. In this project, we will utilize a combination of genetic and cytological approaches to study cytoplasmic inheritance in the model plants Arabidopsis thaliana and Nicotiana tabacum.
The success of our project would represent the first instance of controlled cytoplasmic inheritance in plants. Our fundamental research will provide new tools for testing existing hypotheses regarding cytoplasmic inheritance. From an agricultural standpoint, breeders can leverage this unprecedented capacity to selectively transmit cytoplasmic genomes, thus enabling the inheritance of desired crop traits. The potential application of cytoplasmic inheritance in plant breeding highlights the societal impact of our research.
Campo scientifico (EuroSciVoc)
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
- scienze agricoleagricoltura, silvicoltura e pescaagricoltura
- scienze naturaliscienze biologichegeneticagenomi
È necessario effettuare l’accesso o registrarsi per utilizzare questa funzione
Programma(i)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Argomento(i)
Meccanismo di finanziamento
HORIZON-ERC - HORIZON ERC GrantsIstituzione ospitante
6708 PB Wageningen
Paesi Bassi