Project description
Endoscopic delivery of non-thermal ablation in the oesophagus
Barrett’s oesophagus is a pre-cancerous condition where the lining of the oesophagus is altered, often due to chronic acid reflux. Current endoscopic treatments can remove abnormal tissue but frequently damage deeper, healthy layers, increasing complications. To overcome this limitation, the ERC-funded CLARISURGE project proposes to develop a novel endoscopic cap that precisely delivers local, non-thermal ablation to superficial layers. Designed for full integration with standard endoscopes, the system supports diagnosis and treatment in one procedure. The project will optimise and validate this innovative technology for clinical trials, paving the way for safer therapies for early-stage oesophageal disease.
Objective
Treatments that minimize adverse effects on deep tissues may be critical for successful therapy in a superficial pre-cancerous condition such as Barrett's oesophagus. Although endoscopic therapeutic interventions efficiently eradicate superficial abnormal tissues in the oesophagus, the main challenge with their current deployments is that the therapy depth typically has a more profound thermal injury than the target layer. The project's objective is to develop a novel endoscopic cap that provides local non-thermal ablation to the superficial layers of the target oesophageal wall with sufficient depth for mucosal resurfacing. A design compatible with endoscopes will enable navigation, diagnosis, and ablation together—all-in-one.
In support of the objective, the research programme is split into the following indicative specific aims based on EU MDR (2017/745) ISO (13485) & TSE (60601) regulations. Aim-1: Development of numerical modelling to mimic non-thermal ablation dynamics of the endo-cap. Aim-2: Optimization of numerical modelling with computational accuracy by in-vitro studies. Aim-3: Establishing the quality control process. Aim-4: Configuration of the endo-cap's original design in a CAD program and then realize the design with an optically transparent material containing electrodes for a porcine animal model, in vivo. Aim-5: Integration of the endo-cap with an endoscopy system to construct an endoscope equipped with the endo-cap for preclinical trials. Aim-6: Investigating the functional feasibility of an endoscope system in a GI endoscopy simulator. Aim-7: Validation of the system's oesophageal mucosal resurfacing performance in an in vivo porcine model, including tissue samples for histology examination at different time points.
The action results are thought to mature the original design sufficiently for clinical trials and provide further steps for introducing the oesophageal mucosal resurfacing technique using non-thermal ablation into clinical routine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
- natural sciences biological sciences histology
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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HORIZON.1.1 - European Research Council (ERC)
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(opens in new window) ERC-2024-COG
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35340 İzmir
Türkiye
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