RACE: ERA Chair Initiative for Establishing a Research and Innovation Program of Excellence on Ageing and Longevity at UoC

Informazioni relative al progetto

RACE

ID dell’accordo di sovvenzione: 101176529

DOI

10.3030/101176529

Data della firma CE 31 Ottobre 2024

Data di avvio 1 Marzo 2025

Data di completamento 28 Febbraio 2030

Finanziato da

• Widening participation and spreading excellence

Costo totale

Nessun dato

Contributo UE

€ 2 500 000,00

Coordinato da

PANEPISTIMIO KRITIS
Greece

Periodic Reporting for period 1 - RACE (RACE: ERA Chair Initiative for Establishing a Research and Innovation Program of Excellence on Ageing and Longevity at UoC)

Periodo di rendicontazione: 2025-03-01 al 2026-05-31

Sintesi del contesto e degli obiettivi generali del progetto

Across Europe and much of the developed world, populations are ageing at an unprecedented rate. By 2050, one in three Europeans will be over the age of 65. While people are living longer, these extra years are not always lived in good health. Ageing is the single greatest risk factor for many chronic diseases—including cancer, heart disease, neurodegeneration, and diabetes—that not only diminish quality of life but also strain healthcare systems and economies. The need to extend healthspan—the years of life spent in good health—is becoming one of the most pressing challenges of our time.

Despite the urgency of the problem, our understanding of how and why we age remains limited. Recent advances in biomedicine, however, have revealed that ageing is not simply a passive process. Cellular pathways linked to DNA damage, metabolism, inflammation, and stem cell exhaustion appear to actively contribute to the physical and cognitive decline seen in older age. These insights open new and exciting possibilities for medical interventions that can delay, prevent, or even reverse age-related deterioration.

The RACE project (Research and Innovation Program of Excellence on Ageing and Longevity) addresses this critical scientific and societal challenge. Funded under the EU’s ERA Chair programme, RACE aims to turn the University of Crete (UoC) into a leading centre of excellence in the biology of ageing. By building new research capacity and attracting international expertise, the project will unlock innovative approaches to promote healthy ageing and combat age-related diseases.

At the heart of the project is the recruitment of Prof. Dr. Björn Schumacher, a world-renowned researcher in genome stability and age-related disease, to lead an interdisciplinary research team. This team—based in Crete but connected globally—will study the mechanisms that drive biological ageing, develop strategies to enhance resilience to age-related stress, and explore therapies that extend healthspan.

The overall objectives of RACE are to:
Build a world-class research program on ageing and longevity at UoC, integrating cutting-edge molecular biology, genomics, and translational science.
Advance fundamental understanding of the biological mechanisms behind ageing and age-related diseases.
Develop and test new interventions—including drugs and gene-based therapies—that may prevent or delay degenerative diseases.
Train the next generation of scientists in an international, interdisciplinary environment, with an emphasis on mobility and career development.
Foster innovation by linking research with the private sector, generating patents, and promoting spin-offs.
Reverse brain drain by attracting and retaining top scientific talent in Crete and contributing to the development of a vibrant regional research ecosystem.

By strengthening research excellence and promoting innovation, RACE is expected to have lasting impacts on both science and society. The project aligns with Greece’s and Europe’s smart specialisation strategies and will serve as a model for upgrading scientific capacity in regions currently underrepresented in European research.
Ultimately, RACE aims to shift the paradigm in how we approach ageing—not simply as an inevitable decline, but as a modifiable process—while contributing to healthier, more active, and more independent lives for Europe’s ageing population.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

During the reporting period, the RACE scientific programme was established and initiated under the leadership of the ERA Chair. Research activities focused on genome stability, DNA repair, inflammation and ageing, using C. elegans, cellular systems and mammalian/progeroid models. Experimental work advanced four main areas: metabolic and RNA-structural control of inflammatory responses, m6A-dependent translation after DNA damage, vitamin B12-mediated epigenetic recovery, and targeting the DREAM complex to enhance somatic DNA repair. The required experimental, methodological and training framework was put in place, the research team was integrated, and activities progressed according to plan, with no significant scientific deviations. These achievements strengthened UoC capacity in mechanistic and translational ageing research and established the basis for subsequent validation and therapeutic studies.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

RACE is generating results that extend beyond the current state of the art by uncovering new links between genome instability, RNA regulation, metabolism, inflammation and ageing. Key advances include the identification of RNA-structural mechanisms controlling inflammatory responsiveness, an m6A-dependent pathway that sustains translation of DNA-repair proteins after genotoxic stress, a vitamin B12–methionine–epigenetic axis that promotes recovery from DNA damage, and the targeting of the DREAM complex as a strategy to enhance somatic DNA repair. These findings may support the development of biomarkers, nutritional or pharmacological interventions, and therapeutic approaches for age-related diseases. Further uptake will require validation in additional cellular and animal models, assessment of safety and efficacy, access to translational and clinical collaborations, protection of potentially exploitable intellectual property, and engagement with industry and funding bodies for preclinical development and commercialisation.