Project description
3D bioprinting hydrogel for bone tumour treatment
Bone tissue engineering offers a promising solution for restoring damaged bone tissue. However, current methods face limitations in creating disease models for identifying target genes in tumour recurrence, which hinders the development of preclinical strategies. In this context, the EU-funded TissueEng project aims to use 3D bioprinting to develop a biosensor-impregnated 3D construct for screening bone tumour behaviours and bone defect recovery. The goal is to create a multifunctional 3D bioprinting hydrogel that mimics disease models and identifies targets for osteosarcoma treatment. The project will take a multidisciplinary approach. The findings are expected to impact public healthcare sustainability, benefiting patients across all socio-economic levels.
Objective
Bone tissue engineering has been considered a viable solution Bone tissue engineering has been considered a viable solution for clinical restoration and recovery of defected bone tissue caused by injuries, skeletal dysfunction, and cancer. But current approaches are limited in developing cellular disease models to screen the target genes in tumour relapsing, which enables finding suitable preclinical strategies (animal model). The project will use 3D bioprinting to create an external field driving biosensor-impregnated 3D construct as a potential therapeutic platform for screening bone tumour behaviours and multidisciplinary approaches to bone defect recovery. Hence, the main objective is to determine if the formulation of chiro-magnetic nano-assembly incorporated electro-conductive hydrogel will be able to mimic the in vivo disease model to identify the target of expression in the osteosarcoma model, which will enable the finding of an effective therapeutic strategy for osteosarcoma treatment with gender diversity. The project will focus on the multidisciplinary approach (material science, biochemistry, and cell biology) in the formulation of the multifunctional 3D bioprinting hydrogel (visible light based photo-cross-linkable). The 3D construct will have tunable physical properties such as mechanical stability, chiro-magnetic, etc in determining all stages of cellular behaviour; magnetothermal activity in killing tumour cells; and electro-stimulation mediated osteointegration in tissue regeneration. The project will include the transfer of the candidates knowledge to the host and acquiring extensive training from UAveiro on advanced tools and techniques as a part of the career development plan. The results will have a potential impact on humankind and patients from all socio-economical levels, and they are in line with the EU mission to have a significant economic impact on the sustainability of public healthcare care for low-to medium-earning patients' families.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2023-TALENTS-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3810-193 Aveiro
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.