Project description
3D bioprinting hydrogel for bone tumour treatment
Bone tissue engineering offers a promising solution for restoring damaged bone tissue. However, current methods face limitations in creating disease models for identifying target genes in tumour recurrence, which hinders the development of preclinical strategies. In this context, the EU-funded TissueEng project aims to use 3D bioprinting to develop a biosensor-impregnated 3D construct for screening bone tumour behaviours and bone defect recovery. The goal is to create a multifunctional 3D bioprinting hydrogel that mimics disease models and identifies targets for osteosarcoma treatment. The project will take a multidisciplinary approach. The findings are expected to impact public healthcare sustainability, benefiting patients across all socio-economic levels.
Objective
Bone tissue engineering has been considered a viable solution Bone tissue engineering has been considered a viable solution for clinical restoration and recovery of defected bone tissue caused by injuries, skeletal dysfunction, and cancer. But current approaches are limited in developing cellular disease models to screen the target genes in tumour relapsing, which enables finding suitable preclinical strategies (animal model). The project will use 3D bioprinting to create an external field driving biosensor-impregnated 3D construct as a potential therapeutic platform for screening bone tumour behaviours and multidisciplinary approaches to bone defect recovery. Hence, the main objective is to determine if the formulation of chiro-magnetic nano-assembly incorporated electro-conductive hydrogel will be able to mimic the in vivo disease model to identify the target of expression in the osteosarcoma model, which will enable the finding of an effective therapeutic strategy for osteosarcoma treatment with gender diversity. The project will focus on the multidisciplinary approach (material science, biochemistry, and cell biology) in the formulation of the multifunctional 3D bioprinting hydrogel (visible light based photo-cross-linkable). The 3D construct will have tunable physical properties such as mechanical stability, chiro-magnetic, etc in determining all stages of cellular behaviour; magnetothermal activity in killing tumour cells; and electro-stimulation mediated osteointegration in tissue regeneration. The project will include the transfer of the candidate’s knowledge to the host and acquiring extensive training from UAveiro on advanced tools and techniques as a part of the career development plan. The results will have a potential impact on humankind and patients from all socio-economical levels, and they are in line with the EU mission to have a significant economic impact on the sustainability of public healthcare care for low-to medium-earning patients' families.
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Programme(s)
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
3810-193 Aveiro
Portugal