Project description
Implants for personalised osteochondral tissue regeneration
Osteochondral injuries (OCIs) resulting from trauma or osteonecrosis present a challenge for orthopaedic surgeons. Current tissue regeneration strategies are still under development and must address both subchondral bone and cartilage. Advancing our understanding of OCI mechanisms could lead to breakthrough therapeutic interventions. With the support of the Marie Skłodowska-Curie Actions programme, the EngVIPO project will develop bio-fabricated, patient-specific implants with enhanced vascularity and functionality. The project involves collaborations with institutions specialising in orthopaedic tissue engineering, focusing on innovative biomaterials, advanced manufacturing technologies, in silico modelling, biobanks and personalised medicine for regenerating injured or diseased orthopaedic tissue. It includes the use of advanced biomaterials, cutting-edge manufacturing and cryopreservation technologies, microfluidics, organoids and in vivo evaluation to improve patient outcomes.
Objective
Osteochondral Injuries (OCI) is a challenging yet common clinical problem for orthopaedic surgeons worldwide and is associated with multiple clinical scenarios ranging from trauma to osteonecrosis. Strategies for functional tissue regeneration at still far from the clinics and should endeavour to heal the subchondral bone and joint interface and hyaline cartilage. Enhancing the understanding of the mechanisms that underlie OCI holds the potential to unlock ground-breaking advancements in therapeutic interventions. EngVIPO tackles current challenges in the realm of biofabricated patient-specific implants with enhanced vascularity and functionality, concerning scientific expertise and collaborations with renowned institutions for OC tissue engineering, within the interdisciplinary domains of 3D computational modelling, advanced manufacturing, 3D in vitro models, and nanotechnology, and boosting clinical translation of the tissue engineered products. The project is focused on catapult knowledge exchange and create research synergies on the development of innovative biomaterials and bioinks, emerging technologies, biobanks and personalized medicine, for the complete regeneration and establishment of normal function of injured/diseased OC tissue. This will range from advanced biomaterials/scaffolds incorporating bioactive ions with osteogenic function, implementation of innovative manufacturing technologies, spheroids/organoids integrated into microfluidics, therapeutic biologicals and biobanks, in silico modelling, in vitro immunocompatiblity, to in vivo evaluation. Such innovative approach represents a significant advancement in the field of orthopedics, leading to improved participation of biobanks towards the development of advanced implants and patient outcomes, and setting new standards for personalized implant solutions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesmedical biotechnologytissue engineering
- medical and health scienceshealth sciencespersonalized medicine
- engineering and technologyindustrial biotechnologybiomaterials
- medical and health sciencesmedical biotechnologyimplants
- engineering and technologymedical engineeringdiagnostic imaging
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Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinator
4704 553 Braga
Portugal