Objective
The rapid increase in dengue fever incidence poses a formidable challenge to global public health, with an estimated 100 million symptomatic infections annually and a geographical spread predicted to widen due to climate change and urbanization. The COMBAT initiative, a pioneering European Research Constellation, aims to address this by leveraging advanced technologies and knowledge from endemic regions to develop innovative solutions for dengue prevention and treatment. This project advances super-resolution microscopy to observe rare events in host-virus interactions and introduces novel brain-on-chip technology for in-depth dengue pathogenesis modeling. It focuses on developing innovative antiviral strategies to target dengue virus (DENV) entry and mitigate cytokine storms through host-directed therapy. Furthermore, it leverages multi-omics strategies to identify early predictive biomarkers of severe dengue and develop artificial intelligence tools with the aim of crafting comprehensive policies for the EU’s pandemic preparedness. COMBAT employs a unique experimental strategy that integrates cutting-edge technologies such as super-resolution optical microscopy, AI, and machine learning for advanced modeling of the dengue virus-host interactions and early prediction of severe outcomes. By combining efforts in drug repurposing, development of a brain-on-chip model for neuropathogenesis studies, and employing nanoscale imaging for in-depth analysis of the virus's impact, COMBAT represents a significant leap forward in the fight against dengue. The project not only aims to enhance our understanding of the disease but also to create scalable and affordable tools for pandemic preparedness, setting a new standard in interdisciplinary research to COMBAT viral epidemics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences physical sciences optics microscopy super resolution microscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.5 - Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine
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HORIZON.2.1.4 - Infectious Diseases, including poverty-related and neglected diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2024-DISEASE-08
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.