In silico modelling of cold atmospheric pressure plasma on cholangiocarcinoma

Projektinformationen

InSilicoCAPP

ID Finanzhilfevereinbarung: 101205979

DOI

10.3030/101205979

Das Projekt endete am 9 Juni 2026

EK-Unterschriftsdatum 10 April 2025

Startdatum 2 Januar 2026

Enddatum 1 Januar 2028

Finanziert unter

• Marie Skłodowska-Curie Actions (MSCA)

Gesamtkosten

Keine Daten

EU-Beitrag

€ 190 219,44

Koordiniert durch

UNIVERSITY OF CYPRUS
Cyprus

Periodic Reporting for period 1 - InSilicoCAPP (In silico modelling of cold atmospheric pressure plasma on cholangiocarcinoma)

Berichtszeitraum: 2026-01-02 bis 2028-01-01

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Cholangiocarcinoma (CCA) is one of the most aggressive malignancies of the biliary epithelium, characterised by rapid progression and a poor prognosis, with complete surgical resection remaining the only curative option. Cold atmospheric pressure plasma (CAPP) has recently emerged as a promising oncological technology, offering the unique advantage of localized, targeted tumour treatment while sparing surrounding healthy tissue — a critical limitation of conventional chemo- and radiotherapy. Despite this potential, the interaction between CAPP and tumour tissue remains poorly understood, and precise control of the electric field amplitudes and the reactive oxygen and nitrogen species (RONS) generated during treatment remains a major scientific and technical challenge. Current research is dominated by 1D, 2D, or axisymmetric models of plasma flow, which fail to capture the true complexity and heterogeneity of tumour physiology. Realistic representation of the coupled bio-physical phenomena governing plasma–tumour interaction requires full three-dimensional modelling.
This project proposes the development of a novel, open-source, full 3D multiphysics and multiscale in silico platform to simulate plasma flow and its biological effects within solid tumours. By providing a comprehensive, quantitative understanding of plasma species transport and their interaction with tumour tissue, the platform will enable the optimization of CAPP operational parameters, maximizing therapeutic efficacy while ensuring minimal damage to healthy tissue. In the long term, this framework is expected to yield critical insights into dose–response relationships between plasma intensity and cancer cell response, representing a significant step toward the clinical translation of CAPP as a treatment modality for cholangiocarcinoma.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

The project never started

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The project never started