Project description
Reprogramming synovial cells to restore joint health
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and progressive destruction of joints, leading to pain and disability. Current first-line therapy involves disease-modifying anti-rheumatic drugs (DMARDs) that manage inflammation but cannot repair damaged tissue. With the support of the Marie Skłodowska-Curie Actions programme, the Nano-Synergy project aims to develop mRNA-based nanodelivery systems to reprogramme synovial cells that line the inner part of the joints and are responsible for joint lubrication and nourishment. Researchers will test the combination of targeted mRNA therapy with existing DMARDs in human organoid models and animal models as a regenerative treatment for RA.
Objective
As a Marie Skłodowska-Curie (MSC) fellow, I aim to engineer clinically focused mRNA formulations for rewriting the biology of synovial cells and unlocking regeneration in rheumatoid arthritis, and expand the capabilities of current Disease Modifying Anti-Rheumatic Drugs (DMARDs). The current first-line therapies for rheumatoid arthritis (RA), DMARDs, effectively manage inflammation but do not regenerate destroyed bone tissue, leading to lifelong disability and pain. We hypothesize that reprogramming specific synovial cell types by combining targeted mRNA delivery with approved DMARD therapies can restore the pathological tissue state in arthritis back to a healthy state and enable long-term joint repair. This project, Nano-Synergy, will be supervised by global leader in materials chemistry and tissue engineering Prof. Dame Molly Stevens at the Kavli Institute for Nanoscience Discovery (University of Oxford). I will collaborate with tissue biologists Prof. Chris Buckley and Prof. Mark Coles at the Kennedy Institute of Rheumatology (University of Oxford), the world’s premiere rheumatology research centre. In the host Stevens group, I will rationally engineer mRNA nanodelivery systems which specifically deliver payloads to joint synovial cells by using bio-orthogonal chemistry and revolutionary techniques for characterizing nanoparticle physicochemical properties. I will demonstrate that mRNA synergizes with DMARDs to reprogram arthritis at the cellular level by adapting a state-of-the-art organoid system utilized by Buckley and Coles which spatially and transcriptionally recapitulates human arthritis, and then demonstrate tissue regeneration using an animal model. In summary, as a biomedical engineer and immunologist trained in RNA delivery and animal models of tissue injury, I will integrate unrivalled expertise and capabilities in engineering and rheumatology at Oxford to pioneer new regenerative therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences genetics RNA
- engineering and technology nanotechnology nano-materials
- natural sciences biological sciences histology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.