Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS

Sono-Optical Force Tomography (SOFT)

Obiettivo

Organoids and cancer spheroids are revolutionizing biomedical research. Derived from stem cells, organoids mimic the complexity of organs, provide in vitro systems for human disease modelling, tissue engineering and drug testing, paving the way towards personalized medicine.

SOFT will create an entirely novel non-contact and non-invasive acoustofluidic tool to address open questions and limitations in organoid research. The general idea is inspired by breakthroughs in quantitative methods for holographic optical tweezers. As we have already shown, standing MHz acoustic wave configurations enable optical tomography by rotating the levitated micro-sample into many directions. SOFT will go beyond this and create a FORCE tomogram in the microfluidic chamber by applying structured ultrasound transducer elements acting as emitters and/or sensors of acoustic waves. An inverse problem will be formulated and solved, simultaneously inferring the 3D force field and the sample properties from pressure patterns measured on the micro-fluidic chamber walls.

Acoustic forces lead to controllable strain on the sample. The 3D force map together with the 3D deformation map created by optical tomography will provide the means to reconstruct a spatially resolved ‘stress-strain-diagram’ of the sample. This will, for the first time, allow one to assess and correlate local optical (morphological) and mechanical (functional) properties of the sample, providing a new enabling tool for mechanobiological investigations.

SOFT will study the blood vessel network of organoids. The organ-specific morphology and functionality of vascularization in 3D is of utmost importance, since its dysfunctionality limits organoids to small size. The unique combination of dual optical/acoustical tomographic information, requiring Optics as well as Acoustics expertise, that SOFT provides will enable deep insights into organoid vascular health and development.

Campo scientifico (EuroSciVoc)

Questo progetto non è ancora stato classificato con EuroSciVoc.
Suggerisci i campi scientifici che ritieni più rilevanti e aiutaci a migliorare il nostro servizio di classificazione.

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-ERC - HORIZON ERC Grants

Vedi tutti i progetti finanziati nell’ambito di questo schema di finanziamento

Invito a presentare proposte

(si apre in una nuova finestra) ERC-2025-ADG

Vedi tutti i progetti finanziati nell’ambito del bando

Istituzione ospitante

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Contributo netto dell'UE
€ 2 487 500,00
Indirizzo
CHRISTOPH PROBST PLATZ 1
6020 Innsbruck
Austria
Regione
Westösterreich Tirol Innsbruck
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Beneficiari (1)