Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS

Protoecologies between Artificial Cells and Mammalian Cells

Obiettivo

ProtoEco pioneers a molecular chemistry and systems engineering approach to establish protoecologies – interac-tive communities of artificial cells and mammalian cells – engineered from the molecular scale upward. Moving be-yond isolated artificial cells of today, ProtoEco introduces synthetic–living hybrid communities with sustained metabolic
interactions, adaptive molecular signaling, and feedback loops to build communities with entirely unknown emergent properties at the system level.

We will develop complementary AC platforms sourced from the polymer and DNA realm that are engineered for tunable mechanics, selective responsiveness, robust metabolic encapsulation, and for interactivity on a molecular signaling level. Using photochemical patterning and colloidal assembly methods, ProtoEco will precisely engineer artificial cell–cell architectures in 2D landscapes and 3D co-spheroids. These well-defined systems will allow systematic exploration of the design space for stable, adaptive, and ultimately sustained bidirectional interactions, enabling ecological behaviors and regulation of the tumor microenvironment.

ProtoEco will address key questions: (1) Defining the chemical design space for meaningful artificial cell–cell inter-actions, (2) engineering ecological behaviors and homeostasis at the molecular level, (3) understanding emergent dynamics in biohybrid systems, and (4) enabling novel therapeutic technologies.

Aspects of robotic screening will accelerate optimization of signaling interactions, while robust metabolite and signal tracking and analysis of reciprocal artificial cell–cell interactions will provide deep mechanistic insights. ProtoEco’s fundamental science opens unprecedented pathways toward programmable probiotics, adaptive therapies, and in-teractive biomaterials.

Campo scientifico (EuroSciVoc)

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-ERC - HORIZON ERC Grants

Vedi tutti i progetti finanziati nell’ambito di questo schema di finanziamento

Invito a presentare proposte

(si apre in una nuova finestra) ERC-2025-ADG

Vedi tutti i progetti finanziati nell’ambito del bando

Istituzione ospitante

JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Contributo netto dell'UE
€ 2 592 903,00
Indirizzo
SAARSTRASSE 21
55122 Mainz
Germania
Regione
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Beneficiari (1)