Objective
Unintended pregnancy and unsafe abortion remain major drivers of maternal morbidity and mortality worldwide, hindering progress towards Sustainable Development Goals 3 (health and well-being) and 5 (gender equality). Despite advances in reproductive health, significant gaps remain - contraceptive options are limited by hormonal side effects and poor acceptability; early diagnosis and treatment of ectopic pregnancy remain invasive and fertility-threatening; and the lack of physiologically relevant models prevents insights into endometrial repair and embryo implantation.
INSPIRE introduces a paradigm shift by targeting the endometrium for contraception and builds on my discoveries that progesterone receptor modulators can impair endometrial receptivity without inhibiting ovulation and prevent hormone-driven proliferation in breast epithelium. I propose to develop novel, non-estrogenic contraceptives that may also reduce breast cancer risk. In addition, I will advance new fertility-preserving medical strategies for managing ectopic pregnancy.
I have pioneered the first 3D model of human embryo implantation and INSPIRE will build on this by developing assembloids and multi organ-on-chip platforms for high-resolution, mechanistic studies of endometrial function in health and disease. By integrating clinical trials with spatial transcriptomics, single-cell RNA-seq, and in vitro modelling, INSPIRE will dissect the molecular basis of endometrial-targeted interventions and deliver impactful and transformative, fertility-preserving solutions that redefine contraceptive development and ectopic pregnancy care from bench- to- bedside to global implementation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences social medicine sexual health
- medical and health sciences clinical medicine oncology breast cancer
- social sciences sociology gender studies gender equality
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.