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INnovative Solutions for Pregnancy Intervention and Regulation: Translating Endometrial Science into Contraceptive Innovation and Ectopic Pregnancy Treatment

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Unintended pregnancy and unsafe abortion remain major drivers of maternal morbidity and mortality worldwide, hindering progress towards Sustainable Development Goals 3 (health and well-being) and 5 (gender equality). Despite advances in reproductive health, significant gaps remain - contraceptive options are limited by hormonal side effects and poor acceptability; early diagnosis and treatment of ectopic pregnancy remain invasive and fertility-threatening; and the lack of physiologically relevant models prevents insights into endometrial repair and embryo implantation.

INSPIRE introduces a paradigm shift by targeting the endometrium for contraception and builds on my discoveries that progesterone receptor modulators can impair endometrial receptivity without inhibiting ovulation and prevent hormone-driven proliferation in breast epithelium. I propose to develop novel, non-estrogenic contraceptives that may also reduce breast cancer risk. In addition, I will advance new fertility-preserving medical strategies for managing ectopic pregnancy.

I have pioneered the first 3D model of human embryo implantation and INSPIRE will build on this by developing assembloids and multi organ-on-chip platforms for high-resolution, mechanistic studies of endometrial function in health and disease. By integrating clinical trials with spatial transcriptomics, single-cell RNA-seq, and in vitro modelling, INSPIRE will dissect the molecular basis of endometrial-targeted interventions and deliver impactful and transformative, fertility-preserving solutions that redefine contraceptive development and ectopic pregnancy care from bench- to- bedside to global implementation.

Wissenschaftliches Gebiet (EuroSciVoc)

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Finanzierungsplan

HORIZON-ERC - HORIZON ERC Grants

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Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) ERC-2025-ADG

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Gastgebende Einrichtung

KAROLINSKA INSTITUTET
Netto-EU-Beitrag
€ 2 500 000,00
Adresse
NOBELS VAG 5
171 77 STOCKHOLM
Schweden
Region
Östra Sverige Stockholm Stockholms län
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
Keine Daten

Begünstigte (1)