INnovative Solutions for Pregnancy Intervention and Regulation: Translating Endometrial Science into Contraceptive Innovation and Ectopic Pregnancy Treatment

Objetivo

Unintended pregnancy and unsafe abortion remain major drivers of maternal morbidity and mortality worldwide, hindering progress towards Sustainable Development Goals 3 (health and well-being) and 5 (gender equality). Despite advances in reproductive health, significant gaps remain - contraceptive options are limited by hormonal side effects and poor acceptability; early diagnosis and treatment of ectopic pregnancy remain invasive and fertility-threatening; and the lack of physiologically relevant models prevents insights into endometrial repair and embryo implantation.

INSPIRE introduces a paradigm shift by targeting the endometrium for contraception and builds on my discoveries that progesterone receptor modulators can impair endometrial receptivity without inhibiting ovulation and prevent hormone-driven proliferation in breast epithelium. I propose to develop novel, non-estrogenic contraceptives that may also reduce breast cancer risk. In addition, I will advance new fertility-preserving medical strategies for managing ectopic pregnancy.

I have pioneered the first 3D model of human embryo implantation and INSPIRE will build on this by developing assembloids and multi organ-on-chip platforms for high-resolution, mechanistic studies of endometrial function in health and disease. By integrating clinical trials with spatial transcriptomics, single-cell RNA-seq, and in vitro modelling, INSPIRE will dissect the molecular basis of endometrial-targeted interventions and deliver impactful and transformative, fertility-preserving solutions that redefine contraceptive development and ectopic pregnancy care from bench- to- bedside to global implementation.