Objective
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large and diverse class of natural products that are fundamental to current drug discovery and development. Most of these peptides contain at least one macrocycle and many bear a stereogenic axis on a tryptophan motif, giving rise to atropisomeric macrocyclic peptides. Atropisomers are intrinsically non-planar, bearing shapes that often minimize the entropic penalty upon their binding to biological receptors, often enhancing potency, selectivity or metabolic stability. Nonetheless, drug discovery efforts have been hampered by lack of synthesis methods toward these peptidic atropisomeric molecules. For instance, there is currently no method for peptide macrocyclization toward C–N atropopeptides directly carried out on the indole of tryptophan. Accordingly, in RIPP-SNAr I will develop the first examples of such peptide macrocyclizations, taking advantage of catalytic nucleophilic aromatic substitution (SNAr). The main advantages are: 1) easy access to starting materials; 2) high modularity allowing for incorporation of structural diversity and 3) several possibilities for controlling atroposelective and atropodiastereodivergency. RIPP-SNAr will therefore provide more sustainable organic synthesis and, because new molecules will be tested biologically, may lead to new anticancer or antibacterial entities. My previous experience in synthesis and medicinal chemistry, acquired as PhD student in the United States, will be relevant to the realization of the project; the hallmark of RIPP-SNAr is the symbiosis between my previous experience in synthesis and medicinal chemistry with the experience in stereoselective catalysis from the host group, inserted at IOCB Prague with its long tradition on such interdisciplinary research. This fellowship will ensure that I become a strong candidate for a leadership position in the pharmaceutical industrial sector.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences catalysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
166 10 PRAHA 6
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.