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FACEOFF: Role of intra- and inter-kingdom mixed infections as major determinants of plant virus emergence through short- and long-term modifications of seed transmission rate.

Descrizione del progetto

Dinamiche di trasmissione tramite semi nelle infezioni miste delle piante

I virus delle piante sono responsabili di oltre la metà delle malattie vegetali emergenti, eppure le attuali strategie di gestione spesso trascurano la trasmissione verticale attraverso i semi. Grazie al sostegno del programma di azioni Marie Skłodowska-Curie, il progetto FACEOFF colmerà questa lacuna studiando in che modo le infezioni miste con altri virus o batteri influenzano la trasmissione tramite i semi. FACEOFF mira a capire in che modo la natura di questi agenti coinfettanti, benefici o patogeni che siano, influisca su questo processo. Combinando l’evoluzione sperimentale con l’analisi genomica, il progetto analizzerà i meccanismi molecolari alla base di queste interazioni. I risultati saranno integrati in modelli epidemiologici che utilizzano reti neurali per prevedere la prevalenza del virus, il che costituirà un passo fondamentale per garantire l’approvvigionamento alimentare globale, migliorando il controllo sulle vie di trasmissione nascoste della malattia.

Obiettivo

Plant pests are a main limiting factor for agricultural production, and developing effective control measures is a major requirement to meet the rising food demand of a growing human population. Among pests, viruses account for more than half of emerging plant diseases. A major contributing factor to their emergence is the great capacity of plant viruses to spread rapidly and cause devastating epidemics. Thus, current management methods focus on interfering with their horizontal transmission (HT). However, even when successful, these methods do not prevent virus epidemics as these pests have other dispersal means. The main one is vertical transmission from-parent-to-offspring via seeds (VT), which can be achieved by at least 20% of all known plant viruses. The genetic and ecological determinants of this transmission mode are largely unknown, which hampers providing efficient control measures. One such determinants is the coexistence of plant viruses with other microorganisms in mixed infections within the same plant, which is frequent in nature. Although mixed infections influence many infection traits, their role as modulators of seed transmission is unknown. To fill this gap, FACEOFF will analyze how the type of coinfecting partner (virus-virus and virus-bacteria), its transmission mode (HT or VT) and its relation with the host (beneficial or pathogenic) impact virus seed transmission. The effects of these three factors will be studied in the short- and in the long-term through experimental evolution, and their molecular basis, both in the plant and the virus, will be studied through genomics and transcriptomics. Moreover, the generated data will be integrated in an epidemiological model that integrates neural networks to study how changes in seed transmission induced by mixed infections impact virus prevalence. Thus, FACEOFF will provide an unprecedented understanding on how mixed infections determine virus epidemiology via changes in seed transmission.

Campo scientifico (EuroSciVoc)

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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(si apre in una nuova finestra) HORIZON-MSCA-2025-PF

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Coordinatore

UNIVERSIDAD POLITECNICA DE MADRID
Contributo netto dell'UE
€ 194 074,56
Indirizzo
CALLE RAMIRO DE MAEZTU 7 EDIFICIO RECTORADO
28040 Madrid
Spagna
Regione
Comunidad de Madrid Comunidad de Madrid Madrid
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato