Objective
Neutrophils are the most abundant leukocytes in the organism and represent the first line of immune defence against pathogens. Recent discoveries highlighted a new pro-tumoral subset of neutrophils implicated in the emergence of solid cancer. Yet, the role of this subset of neutrophils in the context of hematological clonal disorders, such as myeloproliferative neoplasms (MPNs), remains under investigated.
MPNs are then characterized by reduced life quality and associated complications: thrombosis, bone marrow scarring impeding normal hematopoiesis (myelofibrosis) and leukemic transformation. These hematological diseases have a major social cost, that will be amplified in the next years with the aging population. Main therapies for MPNs are focused on symptoms and new treatments are needed. We recently discovered that neutrophils produced by MPN cancerous cells in the bone marrow (BM) are characterized by high expression of CD24 (CD24hi) and are involved in the development of myelofibrosis (BM scarring) in MPNs. However, the possible role of CD24 or these inflammatory neutrophils in key co-morbidities in MPN, such as thrombosis (blood clotting) and leukemic transformation, are unknown. This proposal aims at filling this critical gap of knowledge through three independent, yet highly interconnected, work packages: 1) validation of CD24 as functional biomarker for prognosis and novel personalized treatment; 2) role of CD24hi neutrophils in MPN thrombosis risk and 3) impact of CD24hi neutrophils on leukemic transformation. NeutroMPN project merges the expertise of the applicant in hematopoietic mechanisms of leukemic transformation in human and humanised models of MPN with the host group’s knowledge and resources in the microenvironment in MPN and leukemia. A 3-month secondment will provide necessary training in animal models of MPN thrombosis. Together, this project will test a new functional biomarker for prognosis and personalized treatment in MPN.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine oncology leukemia
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
41004 Sevilla
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.