Skip to main content
Ir a la página de inicio de la Comisión Europea (se abrirá en una nueva ventana)
español es
CORDIS - Resultados de investigaciones de la UE
CORDIS

Single-molecule Nanopore Analysis Platform for RNA Readout

Objetivo

RNA viruses, including Zika, SARS-CoV-2, and Hepatitis C, impose a profound global health burden, causing millions of deaths every year. The extraordinary rates of mutations and chemical modifications in these RNA-based pathogens enable rapid adaptation and, ultimately, immune evasion. Current detection technologies fail to capture the molecular heterogeneity that drives viral evolution, relying on ensemble averaging, biased enzymatic amplification, or computational inference to compensate for low signal-to-noise. SNAPRR aims to overcome these limitations by developing a unified single-molecule platform that identifies viral RNAs and their underlying mutations, and chemical modifications, revealing the hidden chemical diversity that shapes infectivity and pathogenesis.

SNAPRR harnesses three emerging technologies to sensitively and specifically probe viral RNA chemistry. 1) Solid-state nanopores translate individual RNA molecules into recognisable ionic current signatures, enabling rapid, quantitative readout. 2) Programmable nucleic acid nanotechnology uniquely barcodes viral RNAs for multiplexed detection, and 3) Chemoselective labelling amplifies signals from single-nucleotide mutations and chemical modifications for direct nanopore localisation.

By revealing strand-to-strand heterogeneity, SNAPRR will redefine our understanding of RNA virus biology, inform next-generation diagnostics, and provide a versatile framework for antiviral development and RNA vaccine quality control. Bridging chemistry, nanotechnology, and biophysics, this project combines fundamental insight with practical impact, creating a portable, amplification-free approach to tackle the global challenge of rapidly evolving RNA viruses.

Ámbito científico (EuroSciVoc)

Este proyecto aún no se ha clasificado con EuroSciVoc.
Sugiera los ámbitos científicos que considere más relevantes y ayúdenos a mejorar nuestro servicio de clasificación.

Palabras clave

Programa(s)

Tema(s)

Régimen de financiación

HORIZON-ERC - HORIZON ERC Grants

Ver todos los proyectos financiados en el marco de este régimen de financiación

Convocatoria de propuestas

(se abrirá en una nueva ventana) ERC-2026-STG

Ver todos los proyectos financiados en el marco de esta convocatoria

Institución de acogida

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Aportación neta de la UEn
€ 1 670 246,00
Dirección
COLLEGE GREEN TRINITY COLLEGE
D02 CX56 Dublin
Irlanda
Región
Ireland Eastern and Midland Dublin
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 1 670 246,00

Beneficiarios (1)