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Cervical Cancers Escaping HPV Screening: Decoding HPV-Independent Carcinogenesis through Multi-Omics Profiling

Ziel

Cervical cancer prevention assumes that most cases are caused by persistent infection with high-risk human papillomavirus (HPV). Yet 7 to 10 percent of invasive cervical cancers are HPV-negative, making them invisible to HPV-based screening and unaffected by vaccination; these cancers are often detected late and have worse outcomes.

This project will define the biology of HPV-independent cervical cancer and enable improved detection. I will lead a Nordic collaboration to assemble, to our knowledge, the largest rigorously confirmed cohort of HPV-negative cancers with matched HPV-positive controls, link them to nationwide registries, and apply an integrated multi-omics strategy (whole-exome DNA sequencing, RNA sequencing, and DNA methylation profiling) to map genomic, transcriptomic, and epigenomic trajectories. Crucially, I will test the hit-and-run hypothesis by reanalyzing earlier screening samples from the same women retrieved from national biobanks. From these data, I will develop and validate clinically actionable biomarkers with a clear path to implementation, and pilot their integration into confirmatory testing and national screening audits.

The outcome will be a population-based molecular taxonomy of HPV-independent cervical cancer and a route to earlier detection for women whose cancers escape the HPV paradigm, directly supporting the World Health Organization’s cervical cancer elimination strategy and strengthening European screening practice.

Wissenschaftliches Gebiet (EuroSciVoc)

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Thema/Themen

Finanzierungsplan

HORIZON-ERC - HORIZON ERC Grants

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Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) ERC-2026-STG

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Gastgebende Einrichtung

KAROLINSKA INSTITUTET
Netto-EU-Beitrag
€ 1 493 450,00
Adresse
NOBELS VAG 5
171 77 STOCKHOLM
Schweden
Region
Östra Sverige Stockholm Stockholms län
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 1 493 450,00

Begünstigte (1)