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CORDIS

CARBOMED: Intelligent Electrified Carbonylation Platform for Sustainable Flow Manufacturing

Obiettivo

CARBOMED aims to translate a breakthrough from the ERC Consolidator Grant CARBOFLOW into a modular, autonomous synthesis platform that integrates high-temperature CO2 electrolysis with continuous-flow carbonylation chemistry and real-time machine learning control. While the primary application field is pharmaceutical manufacturing, the underlying technology establishes a broadly applicable platform for electrified carbonylation processes across the chemical industry.

Amide bonds are among the most ubiquitous functional groups in fine chemicals and in active pharmaceutical ingredients (APIs), yet conventional synthesis routes remain environmentally and operationally inefficient, relying on stoichiometric coupling agents or hazardous, pressurized carbon monoxide. CARBOMED introduces a fully integrated, digitally augmented synthesis platform that electrochemically reduces CO2 to CO and immediately channels it into a closed-loop continuous-flow reactor. This system is enhanced by a machine learning optimization engine that dynamically tunes process parameters - such as temperature, pressure, and residence time -based on real-time data from inline infrared spectroscopy.

The PoC project will demonstrate the platform’s performance across three high profile drug-relevant amides and validate its robustness, selectivity, and sustainability. Technical activities include reactor integration, catalyst testing, ML-based optimization, and mid-scale operation under industrially relevant conditions. The project de-risks the technology as a transferable platform suitable for pharmaceutical companies while offering clear expansion potential into wider carbonylation-based chemical production. Ultimately, CARBOMED offers a modular, scalable, and sustainable synthesis platform using carbon circularity and AI-guided automation, setting the stage for next-generation green chemistry applications.

Campo scientifico (EuroSciVoc)

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants

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Invito a presentare proposte

(si apre in una nuova finestra) ERC-2026-POC

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Istituzione ospitante

TECHNISCHE UNIVERSITAET WIEN
Contributo netto dell'UE
€ 150 000,00
Indirizzo
KARLSPLATZ 13
1040 Wien
Austria
Regione
Ostösterreich Wien Wien
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Beneficiari (1)