Skip to main content
DeutschDE
European Commission logo print header

Novel Methods leading to New Medications in Depression and Schizophrenia

Ziel

Despite dramatic advances in molecular and imaging technologies and nearly 1 5,000 articles on schizophrenia and depression (S&D) there are few novel treatments. We think this is because of three major “bottle-necks”: a lack of etiologically-driven or pathophysiologically-accurate animal models; a lack of tests that provide indication of efficacy in healthy volunteers; and the reliance of clinical trials on DSM categories which provide a collection of biologically heterogeneous patients. Our broad working hypothesis is that a focus on cross-species endophenotypes, testing in healthy volunteers and finding biologically-homogenous groups of patients will overcome existing limitations in target identification, early triage and clinical trials. To implement this idea six leading European institutions and two SMEs will partner with the EFPIA to: a) develop animal models that carry confirmed genetic risks, and in these animals to focus on cross-species endophenotypes (e.g. cognitive function, electrophysiology) to facilitate new drug discovery; b) validate the use of fMRI-based endopheno types in genetically-selected healthy volunteers and patients as early and surrogate markers for efficacy; and to combine this with PET approaches for plasma-kinetics to brain-dynamics modelling to provide guidance regarding optimal clinical trial design; and c) identify pharmacogenetic and multi-omic biomarkers that can be used to stratify patients within an umbrella DSM-diagnosis, thus allowing for ) targeted clinical trials, individualized treatment and back-translation of subgroup-specific biomarkers into preclinical drug discovery. To increase the chance of a breakthrough we will implement new analytical approaches (e.g. support vector machine learning algorithms; Bayesian analyses) and will
actively collaborate with other ongoing international efforts (esp. the Biomarkers Consortium, NIH).

Wissenschaftliches Gebiet

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

IMI-JU-01-2008
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Koordinator

H. LUNDBECK AS
EU-Beitrag
Keine Daten
Adresse
OTTILIAVEJ 7-9
2500 Valby
Dänemark

Auf der Karte ansehen
Region
Danmark Hovedstaden Byen København
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Hauptforscher
Tine Bryan Stensbøl (Dr)
Kontakt Verwaltung
Ejner Moltzen (Dr)
Links
Gesamtkosten
Keine Daten

Beteiligte (19)

Diese Seite teilen

Herunterladen

Letzte Aktualisierung: 5 April 2023

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/115008/de

European Union, 2024