Objectif
The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.
There is heterogeneity in who develops diabetes, the rate at which their subsequent diabetes progresses, how they respond to diabetes therapy and who develops micro- and macrovascular complications. In the DIRECT consortium we propose to identify biomarkers to identify subtypes with rapid diabetes development and progression and altered response to diabetes treatments, and develop and use these biomarkers in clinical trials.
Two phenotyping work packages will focus on glycaemic deterioration and therapeutic response. For each, the DIRECT consortium brings considerable existing resource, which will be augmented by large-scale prospective cohort collection with intensive physiological and imaging phenotyping. Additional data will be added, such as existing studies on acute response to intravenous beta-cell secretagogues, and functional genomics on human islets, liver, muscle and adipose tissue, to maximise the power and utility of an innovative integrated biology approach. To enable computational multi-level integration across phenotypes and data types, a robust and secure data repository will be developed with strict data governance. As the ultimate aim of DIRECT is patient stratification, biomarkers arising from the discovery work will be used to design one or more prospective clinical trials. These will validate the biomarker(s) of interest, and establish utility in clinical practice and/or trial design and drug development. As a result, this consortium offers considerable potential to achieve major progress towards a personalized medicines approach to the treatment of type 2 diabetes.
Champ scientifique
Appel à propositions
IMI-JU-03-2010
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Régime de financement
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Coordinateur
65929 Frankfurt Am Main
Allemagne
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Participants (25)
DD1 4HN Dundee
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BA2 7AY Bath
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00185 Roma
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2800 Kongens Lyngby
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72074 Tuebingen
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85764 Neuherberg
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08036 Barcelona
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SW7 2AZ LONDON
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100 44 Stockholm
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75794 Paris
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2333 ZA Leiden
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1165 Kobenhavn
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70211 KUOPIO
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22100 Lund
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NE1 7RU Newcastle Upon Tyne
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EX4 4QJ Exeter
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1211 Geneve
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OX1 2JD Oxford
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89081 Ulm
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1081 HV Amsterdam
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2880 Bagsvaerd
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RG21 4FA Basingstoke
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92284 Courbevoie
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59037 Lille
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55218 Ingelheim
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