Objectif Antimicrobial resistance (AMR) is widespread. Its global human and economic burden is tremendous and increasing annually. Yet today only a few pharmaceutical companies retain active antibacterial drug discovery programmes. While the elaboration of antibiotics with novel mechanisms of action is scientifically complex, the chief challenge is diminishing incentives. Pre-market regulatory requirements and increased control on post-market access, use, and pricing of new antibiotics are strong deterrents to drug development. Meanwhile, healthcare payers are not currently prepared to reimburse antibiotics at prices that would support the cost of development.Applied to antibiotics, a simple sales-based economic model contradicts the public health mandate to reduce their consumption in order to preserve their efficacy. Alternative models that can create incentives for the discovery of novel antibiotics and yet reconcile these incentives with responsible antibiotic use are long overdue.The multidisciplinary and multi-stakeholder DRIVE-AB consortium composed of 16 public and 8 private partners from 12 countries will produce new models in a stepwise yet interconnected process. To achieve this objective, the DRIVE-AB consortium has put together a strong team that comprises both currently active researchers on the antibiotics problem and new researchers who can bring a fresh perspective as well as experience from other industries, economic specialties, and business cultures. The academic team has been enriched by EFPIA members and stakeholders from various backgrounds. With this diverse, yet closely tied team, DRIVE-AB will deliver fresh, sustainable solutions to this complex problem.First, we will develop an evidence-based, consensus definition for “responsible antibiotic use,” which, with its standardised quality and quantity indicators, will provide the framework for all later steps. Next, data from surveillance systems, antibiotic prescription databases, and published literature will inform estimations of the present burden of antibiotic resistance from both clinical and economic perspectives across varying socioeconomic backdrops. Simulation models informed by these data as well as data from past and ongoing epidemics will estimate future public health needs and impact related to AMR, again in diverse socioeconomic settings. Together these constructs will allow for valuation models that will estimate the true value of existing and new antibiotics from the perspectives of patients, physicians, payers, and society as a whole. These, in turn, will inform the creation of alternative economic strategies and reward models that will promote and sustain the development of new antibiotics while simultaneously bolstering appropriate use of existing antibiotics. The most promising schemes will be presented to policymakers and other stakeholders with attendant implementation and risk-management strategies.This ambitious project will not succeed if it is developed and championed merely by one sector of society, be it academia, “big pharma,” or public health. The robustness and applicability of the proposed alternative models will only be proportional to their level of input from all involved players. All work from beginning to end will be performed in close collaboration with the consortium’s stakeholder partners, which run the gamut from patients and clinical societies to small- and medium-sized enterprises, large pharmaceutical companies, healthcare payers, public health officials, and government officials. The DRIVE-AB consortium will dedicate considerable resources to this collaboration and to the final dissemination of information to policymakers and the wider public.Overall, we are confident that the work of the DRIVE-AB consortium will have an immense impact. This is an unprecedented gathering of experts and stakeholders, led by renowned experts in various fields of medical, public health and economic sciences, to solve Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Thème(s) IMI-JU-09-2013-03 - ND4BB Topic 4: Driving Re-Investment In R&D And Responsible Use Of Antibiotics Appel à propositions IMI-JU-09-2013 Voir d’autres projets de cet appel Régime de financement JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinateur ASTRAZENECA AB Contribution de l’UE Aucune donnée Adresse Vastra Maelarhamnen 151 85 Sodertaelje Suède Voir sur la carte Région Östra Sverige Stockholm Stockholms län Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Chercheur principal Judith Hackett (Global Payer Evidence Director) Contact administratif Eva Lindgren (Senior Director) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (22) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITE DE GENEVE Suisse Contribution de l’UE € 1 670 756,00 Adresse RUE DU GENERAL DUFOUR 24 1211 Geneve Voir sur la carte Région Schweiz/Suisse/Svizzera Région lémanique Genève Type d’activité Higher or Secondary Education Establishments Contact administratif Fabricio Jantarada (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITEIT ANTWERPEN Belgique Contribution de l’UE € 74 770,00 Adresse PRINSSTRAAT 13 2000 Antwerpen Voir sur la carte Région Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Type d’activité Higher or Secondary Education Establishments Contact administratif Anne Adams (Mrs) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée STICHTING RADBOUD UNIVERSITEIT Pays-Bas Contribution de l’UE € 280 445,00 Adresse HOUTLAAN 4 6525 XZ Nijmegen Voir sur la carte Région Oost-Nederland Gelderland Arnhem/Nijmegen Type d’activité Higher or Secondary Education Establishments Contact administratif Andrea Kroon (mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UPPSALA UNIVERSITET Suède Contribution de l’UE € 933 080,00 Adresse VON KRAEMERS ALLE 4 751 05 Uppsala Voir sur la carte Région Östra Sverige Östra Mellansverige Uppsala län Type d’activité Higher or Secondary Education Establishments Contact administratif Gustav Sigeman (EU Research Officer) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Ursula Theuretzbacher Autriche Contribution de l’UE € 351 640,00 Adresse Eckpergasse 1180 Vienna Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Ursula Theuretzbacher (n.a.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée British Society for Antimicrobial Chemotherapy Royaume-Uni Contribution de l’UE € 276 662,00 Adresse Regent Place B1 3NJ Birmingham Voir sur la carte Contact administratif Tracey Kay Guise (Mrs) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée THE ROYAL INSTITUTE OF INTERNATIONAL AFFAIRS Royaume-Uni Contribution de l’UE € 229 839,00 Adresse ST JAMES S SQUARE 10 CHATHAM HOUSE SW1Y 4LE LONDON Voir sur la carte Région London Inner London — West Westminster Type d’activité Other Contact administratif Claire Munoz Parry (Ms) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée EBERHARD KARLS UNIVERSITAET TUEBINGEN Allemagne Contribution de l’UE € 276 703,00 Adresse GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Voir sur la carte Région Baden-Württemberg Tübingen Tübingen, Landkreis Type d’activité Higher or Secondary Education Establishments Contact administratif Evelina Tacconelli (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FOLKEHELSEINSTITUTTET Norvège Contribution de l’UE € 899 100,00 Adresse LOVISENBERGGATA 8 0456 Oslo Voir sur la carte Région Norge Oslo og Viken Oslo Type d’activité Research Organisations Contact administratif Christine Aardal (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE Royaume-Uni Contribution de l’UE € 91 078,00 Adresse Houghton Street 1 WC2A 2AE London Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Contact administratif Milena Vasileva (Research Award Manager) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée SVEUCILISTE U RIJECI, MEDICINSKI FAKULTET Croatie Contribution de l’UE € 24 300,00 Adresse BRACE BRANCHETTA 20 51000 Rijeka Voir sur la carte Région Hrvatska Jadranska Hrvatska Primorsko-goranska županija Type d’activité Higher or Secondary Education Establishments Contact administratif Iva Križanec Ropac (dipl.iur.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Allemagne Contribution de l’UE € 56 817,00 Adresse SEMINARSTRASSE 2 69117 Heidelberg Voir sur la carte Région Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Type d’activité Higher or Secondary Education Establishments Contact administratif Wiebke Tubbesing (Ms) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV Israël Contribution de l’UE € 394 955,00 Adresse WEIZMANN STREET 6 64239 Tel Aviv Voir sur la carte Type d’activité Research Organisations Contact administratif Galit Cohen (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITE DE LORRAINE France Contribution de l’UE € 130 403,00 Adresse COURS LEOPOLD 34 54052 Nancy Cedex Voir sur la carte Région Grand Est Lorraine Meurthe-et-Moselle Type d’activité Higher or Secondary Education Establishments Contact administratif Serge BRIANCON (Professeur) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Royaume-Uni Contribution de l’UE Aucune donnée Adresse Great West Road 980 TW89GS Brentford Voir sur la carte Région London Outer London — West and North West Hounslow and Richmond upon Thames Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Sally Miles (Ms) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée WAGENINGEN UNIVERSITY Pays-Bas Contribution de l’UE € 37 059,00 Adresse DROEVENDAALSESTEEG 4 6708 PB Wageningen Voir sur la carte Région Oost-Nederland Gelderland Veluwe Type d’activité Higher or Secondary Education Establishments Contact administratif Oscar Van Rootselaar (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF STRATHCLYDE Royaume-Uni Contribution de l’UE € 572 380,00 Adresse Richmond Street 16 G1 1XQ Glasgow Voir sur la carte Région Scotland West Central Scotland Glasgow City Type d’activité Higher or Secondary Education Establishments Contact administratif David McBeth (Dr) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ASTELLAS PHARMA EUROPE LTD Royaume-Uni Contribution de l’UE Aucune donnée Adresse 2000 HILLSWOOD DRIVE KT16 0RS Chertsey Voir sur la carte Région South East (England) Surrey, East and West Sussex West Surrey Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif CHRISTOPHER LONGSHAW (DR) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MERCK SHARP & DOHME CORP États-Unis Contribution de l’UE Aucune donnée Adresse ONE MERCK DRIVE 08889 Whitehouse Station Nj Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Nicole Mahoney (Director, Global Regulatory Policy) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée F. HOFFMANN-LA ROCHE AG Suisse Contribution de l’UE Aucune donnée Adresse GRENZACHERSTRASSE 124 4070 Basel Voir sur la carte Région Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Jason Hannon (Ph.D.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée PFIZER LIMITED Royaume-Uni Contribution de l’UE Aucune donnée Adresse RAMSGATE ROAD CT13 9NJ Sandwich Voir sur la carte Région South East (England) Kent East Kent Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Olga Krylova (Dr) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France Contribution de l’UE Aucune donnée Adresse 82 AVENUE RASPAIL 94250 GENTILLY Voir sur la carte Région Ile-de-France Ile-de-France Val-de-Marne Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Nathalia MURILLO (Dr) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée