Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 | INNODIA | Project | Results | H2020 | CORDIS

Resultado final

Characterization of the role for post- translational modifications, alternative splicing and endoplasmic reticulum stress for β-cell recognition by the immune system

Migration

Discovery and pre-clinical validation of novel biomarkers of β-cell mass, dysfunction and death in human T1D

Migration

A comprehensive pan-European research network for the study of the aetiology and prevention of T1D

Migration

Successful start-up of the project - Kick Off Meeting

Migration

EUnPOD functioning

Migration

Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D

Migration

Imaging tool for -cell inflammation/death

Migration

Development of novel approaches for in vivo β-cell imaging

Migration

Plan for access to the CTN by third parties

Migration

Novel models of the cross talk between human β-cells and the human system in vitro

Migration

Discovery analysis of novel biomarkers in β- cell-omics, immunomics, genomics, transcriptomics, proteomics, metabolomics and lipidomics

Migration

Launch public website

Migration

Publicaciones

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Autores: Alexia Carré, Sarah J. Richardson, Etienne Larger, Roberto Mallone
Publicado en: Diabetologia, Edición 64/1, 2021, Página(s) 15-25, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-020-05298-y

The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.

Autores: Mallone R, You S.
Publicado en: Diabetes, Edición 70(6), 2021, Página(s) 1247-1249, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/dbi21-0011

Arresting or curing type 1 diabetes: an elusive goal, but closing the gap.

Autores: Martens PJ, Gysemans C, Mathieu C.
Publicado en: The Journal of endocrinology, Edición 249(2), 2021, Página(s) T1-T11, ISSN 0022-0795
Editor: Society for Endocrinology
DOI: 10.1530/joe-20-0552

Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

Autores: Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
Publicado en: iScience, 2022, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2021.103653

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.

Autores: Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
Publicado en: NAR genomics and bioinformatics, Edición 4(4), 2022, Página(s) lqac084, ISSN 2631-9268
Editor: [Oxford] : Oxford University Press, [2019]-
DOI: 10.1093/nargab/lqac084

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.

Autores: Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
Publicado en: Frontiers in molecular biosciences., Edición 8:689799, 2021, ISSN 2296-889X
Editor: Frontiers Media S.A.,
DOI: 10.3389/fmolb.2021.689799

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes

Autores: Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperbe
Publicado en: Diabetologia, Edición 66(7), 2023, Página(s) 1273-1288, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-023-05912-9

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.

Autores: Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
Publicado en: Diabetes., Edición 72(1), 2022, Página(s) 85-96, ISSN 1939-327X
Editor: [New York, American Diabetes Association]
DOI: 10.2337/db22-0191

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Autores: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Publicado en: Nature Reviews Endocrinology, Edición 16/7, 2020, Página(s) 349-362, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

Autores: Moulder R, Välikangas T, Hirvonen MK, Suomi T, Brorsson CA, Lietzén N, Bruggraber SFA, Overbergh L, Dunger DB, Peakman M, Chmura PJ, Brunak S, Schulte AM, Mathieu C, Knip M, Elo LL, Lahesmaa R; INNODIA consortium
Publicado en: Diabetologia, Edición 66(11), 2023, Página(s) 1983-1996, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-023-05974-9

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Autores: Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Publicado en: Cell Reports, Edición 31/1, 2020, Página(s) 107469, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Autores: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson, Appakalai N. Balamurugan, Carmella Evans-Molina, Decio L. Eizirik, Kieren J. Mather, Silva Arslanian, Raghavendra G
Publicado en: Clinical Epigenetics, Edición 12/1, 2020, Página(s) 116, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-020-00906-5

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Autores: Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew N. Wakeling, Federica Fantuzzi, Kashyap Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas W. Laver, Matthew B. Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Nuri Ozbek, Edip Unal, Ruken Yıldırım, Tusha
Publicado en: Journal of Clinical Investigation, Edición 130/12, 2020, Página(s) 6338-6353, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci141455

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.

Autores: Colli ML, Szymczak F, Eizirik DL.
Publicado en: Frontiers in endocrinology., 2020, Página(s) 11:568446, ISSN 1664-2392
Editor: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.568446

Area Deprivation and Regional Disparities in Treatment and Outcome Quality of 29,284 Pediatric Patients With Type 1 Diabetes in Germany: A Cross-sectional Multicenter DPV Analysis

Autores: Marie Auzanneau, Stefanie Lanzinger, Barbara Bohn, Peter Kroschwald, Ursula Kuhnle-Krahl, Paul Martin Holterhus, Kerstin Placzek, Johannes Hamann, Rainer Bachran, Joachim Rosenbauer, Werner Maier
Publicado en: Diabetes Care, Edición 41/12, 2018, Página(s) 2517-2525, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc18-0724

RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures

Autores: Piron A, Szymczak F, Papadopoulou T, Alvelos MI, Defrance M, Lenaerts T, Eizirik DL, Cnop M
Publicado en: Life science alliance, Edición 7(2), 2023, Página(s) e202302203, ISSN 2575-1077
Editor: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302203

Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.

Autores: Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
Publicado en: The Journal of biological chemistry., Edición 298, 2022, Página(s) 7, ISSN 1083-351X
Editor: Baltimore, MD : American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2022.102096

Preventing type 1 diabetes in childhood.

Autores: Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
Publicado en: Science, Edición 373(6554), 2021, Página(s) 506-510, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abi4742

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Autores: Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
Publicado en: Auto- immunity highlights., Edición 12(1), 2021, Página(s) 6, ISSN 2038-0305
Editor: Springer Verlag Italia
DOI: 10.1186/s13317-021-00148-2

The Role of Beta Cell Recovery in Type 2 Diabetes Remission.

Autores: Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
Publicado en: International journal of molecular sciences., Edición 23(13), 2022, Página(s) 7435, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137435

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Autores: Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
Publicado en: Frontiers in immunology., Edición 12:744509, 2021, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.744509

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes

Autores: Bart O Roep
Publicado en: Frontiers in immunology, Edición 14, 2023, Página(s) 14:1112858, ISSN 1664-3224
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1112858

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Autores: Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
Publicado en: Frontiers in immunology, Edición 12:683091, 2021, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.683091

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Autores: Mallone R, Halliez C, Rui J, Herold KC.
Publicado en: Diabetes, Edición 71(8), 2022, Página(s) 1603-1610, ISSN 1939-327X
Editor: [New York, American Diabetes Association]
DOI: 10.2337/dbi21-0036

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.

Autores: Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
Publicado en: Cells, Edición 11(15), 2022, Página(s) 2465, ISSN 2073-4409
Editor: Basel, Switzerland : MDPI
DOI: 10.3390/cells11152465

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Autores: Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group.
Publicado en: European journal of immunology., Edición 52(3), 2022, Página(s) 372–388., ISSN 1521-4141
Editor: Weinheim, Verlag Chemie GmbH.
DOI: 10.1002/eji.202049067

The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes

Autores: Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
Publicado en: Diabetologia, Edición 66(6), 2023, Página(s) 1129–1141, ISSN 1432-0428
Editor: Berlin Springer Verlag
DOI: 10.1007/s00125-023-05888-6

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Autores: Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
Publicado en: Frontiers in endocrinology, Edición 13, 2022, Página(s) 1058345, ISSN 1664-2392
Editor: [Lausanne : Frontiers Research Foundation]
DOI: 10.3389/fendo.2022.1058345

Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism

Autores: Alena Welters, Thomas Meissner, Jürgen Grulich-Henn, Elke Fröhlich-Reiterer, Katharina Warncke, Klaus Mohnike, Oliver Blankenstein, Ulrike Menzel, Nicolin Datz, Esther Bollow, Reinhard W. Holl
Publicado en: Orphanet Journal of Rare Diseases, Edición 13/1, 2018, ISSN 1750-1172
Editor: BioMed Central
DOI: 10.1186/s13023-018-0970-8

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Autores: Perez-Hernandez J, Chiurchiu V, Perruche S, You S
Publicado en: Frontiers in immunology, Edición 12, 2021, Página(s) 768133, ISSN 1664-3224
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.768133

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Autores: Arif S, Domingo-Vila C, Pollock E, Christakou E, Williams E, Tree T.
Publicado en: Frontiers in immunology, Edición 14, 2023, Página(s) 14:1183909, ISSN 1664-3224
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1183909

Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.

Autores: Carré A, Mallone R.
Publicado en: Frontiers in immunology., Edición 12:639682, 2020, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.639682

The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

Autores: Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M.
Publicado en: Journal of Clinical Medicine, Edición 11(3), 2022, Página(s) 663, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11030663

Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes: A matched case‐control study

Autores: Stefanie Lanzinger, Alena Welters, Angelika Thon, Katja Konrad, Thomas Kapellen, Jürgen Grulich‐Henn, Dirk Raddatz, Reinhard W. Holl
Publicado en: Pediatric Diabetes, Edición 20/7, 2019, Página(s) 955-963, ISSN 1399-543X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12894

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.

Autores: Gootjes C, Zwaginga JJ, Roep BO, Nikolic T.
Publicado en: Frontiers in immunology., Edición 13, 2022, Página(s) 886736, ISSN 1664-3224
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.886736

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Autores: Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Publicado en: Islwts, Edición 13(3-4), 2021, Página(s) 51-65, ISSN 1938-2014
Editor: Landes Bioscience
DOI: 10.1080/19382014.2021.1948282

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.

Autores: Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
Publicado en: Frontiers in endocrinology., Edición 13, 2022, Página(s) 908248, ISSN 1664-2392
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.908248

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Autores: Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
Publicado en: Nature biotechnology., Edición 40(7), 2022, Página(s) 1042–1055, ISSN 1546-1696
Editor: Nature Publishing Company
DOI: 10.1038/s41587-022-01219-z

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.

Autores: Vig S, Lambooij JM, Zaldumbide A, Guigas B.
Publicado en: Frontiers in immunology, Edición 12:669492, 2021, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.669492

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Autores: Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
Publicado en: Cells, Edición 10(1), 2021, Página(s) 191, ISSN 2073-4409
Editor: Basel, Switzerland : MDPI
DOI: 10.3390/cells10010191

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

Autores: Tesi M, Bugliani M, Ferri G, Suleiman M, De Luca C, Bosi E, Masini M, De Tata V, Gysemans C, Cardarelli F, Cnop M, Eizirik DL, Marchetti P, Marselli L.
Publicado en: Biomolecules, Edición 11(2), 2021, Página(s) 320, ISSN 2218-273X
Editor: Basel, Switzerland : MDPI
DOI: 10.3390/biom11020320

Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.

Autores: Samassa F, Mallone R.
Publicado en: Current opinion in endocrinology, diabetes, and obesity., Edición 29(4), 2022, Página(s) 370-378, ISSN 1752-2978
Editor: London : Lippincott, Williams & Wilkins, 2007-
DOI: 10.1097/med.0000000000000735

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Autores: Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko
Publicado en: Diabetes, Edición 68/7, 2019, Página(s) 1366-1379, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db19-0119

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Autores: Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
Publicado en: Life science alliance, Edición 4(3), 2020, Página(s) e202000825, ISSN 2575-1077
Editor: Life Science Alliance, LLC,
DOI: 10.26508/lsa.202000825

Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Autores: Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
Publicado en: Diabetologia, Edición 64(12), 2021, Página(s) 2731-2740, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-021-05563-8

Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Autores: Eizirik DL, Szymczak F, Mallone R.
Publicado en: Nature reviews. Endocrinology, Edición 19(7), 2023, Página(s) 425-434, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-023-00826-3

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology

Autores: Diego Balboa, Jonna Saarimäki-Vire, Timo Otonkoski
Publicado en: STEM CELLS, Edición 37/1, 2019, Página(s) 33-41, ISSN 1066-5099
Editor: AlphaMed Press Inc
DOI: 10.1002/stem.2913

Conjugation to a cell-penetrating peptide drives the tumour accumulation of the GLP1R antagonist exendin(9-39)

Autores: Collado Camps E, van Lith SAM, Kip A, Frielink C, Joosten L, Brock R, Gotthardt M.
Publicado en: European journal of nuclear medicine and molecular imaging, Edición 50(4), 2022, Página(s) 996–1004, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1007/s00259-022-06041-y

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

Autores: Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Guido Sebastiani, Francesco Dotta
Publicado en: Frontiers in Endocrinology, Edición 11, 2020, ISSN 1664-2392
Editor: Front Endocrinol (Lausanne)
DOI: 10.3389/fendo.2020.596898

Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention

Autores: Carré A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R.
Publicado en: Endocrine reviews, Edición 44(4), 2023, Página(s) 737-751, ISSN 1945-7189
Editor: Endocrine Society
DOI: 10.1210/endrev/bnad007

Epitope-based precision immunotherapy of Type 1 diabetes

Autores: Firdessa Fite R, Bechi Genzano C, Mallone R, Creusot RJ.
Publicado en: Human vaccines and immunotherapeutics, Edición 19(1), 2023, Página(s) 2154098, ISSN 2164-5515
Editor: Landes Bioscience
DOI: 10.1080/21645515.2022.2154098

Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction

Autores: Pugliese LA, De Lorenzi V, Bernardi M, Ghignoli S, Tesi M, Marchetti P, Pesce L, Cardarelli F
Publicado en: Scientific reports, Edición 13(1), 2023, Página(s) 13342, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-40272-9

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

Autores: Bart O Roep, Daniel C S Wheeler, Mark Peakman
Publicado en: The Lancet Diabetes & Endocrinology, Edición 7/1, 2019, Página(s) 65-74, ISSN 2213-8587
Editor: Elsevier BV
DOI: 10.1016/s2213-8587(18)30109-8

Transcription factors that shape the mammalian pancreas

Autores: Rachel E. Jennings, Raphael Scharfmann, Willem Staels
Publicado en: Diabetologia, Edición 63/10, 2020, Página(s) 1974-1980, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-020-05161-0

Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death

Autores: Roca-Rivada A, Marín-Cañas S, Colli ML, Vinci C, Sawatani T, Marselli L, Cnop M, Marchetti P, Eizirik DL
Publicado en: Diabetologia, Edición 66(8), 2023, Página(s) 1544-1556, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-023-05908-5

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

Autores: Maikel L. Colli, Mireia Ramos-Rodríguez, Ernesto S. Nakayasu, Maria I. Alvelos, Miguel Lopes, Jessica L. E. Hill, Jean-Valery Turatsinze, Alexandra Coomans de Brachène, Mark A. Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgensen, Lorella Marselli, Piero Marchetti, Sarah J. Richardson, Noel G. Morgan, Thomas O. Metz, Lor
Publicado en: Nature Communications, Edición 11/1, 2020, Página(s) 2584, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16327-0

Every islet matters: improving the impact of human islet research

Autores: Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M.
Publicado en: Nature metabolism, Edición 4(8), 2022, Página(s) 970-977, ISSN 2522-5812
Editor: Berlin : Springer Nature
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Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet

Autores: De Burghgrave M, Lourenço C, Berthault C, Aiello V, Villalba A, Fouque A, Diedisheim M, You S, Oshima M, Scharfmann R.
Publicado en: Cells, Edición 12(1), 2022, Página(s) 113, ISSN 2073-4409
Editor: Basel, Switzerland : MDPI
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Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review

Autores: Tommi Suvitaival
Publicado en: Current diabetes reports, Edición 20(9), 2020, Página(s) 46, ISSN 1534-4827
Editor: Current Science Inc.
DOI: 10.1007/s11892-020-01326-8

Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion.

Autores: Zakaria A, Berthault C, Cosson B, Jung V, Guerrera IC, Rachdi L, Scharfmann R.
Publicado en: The Journal of biological chemistry., Edición 297(1), 2021, Página(s) 100839, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
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Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.

Autores: Kaur S, Frørup C, Mirza AH, Fløyel T, Yarani R, Colli ML, Johannesen J, Størling J, Eizirik DL, Pociot F.
Publicado en: Non-coding RNA, Edición 8(5), 2022, Página(s) 69, ISSN 2311-553X
Editor: Basel, Switzerland : MDPI AG, [2015]-
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Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention

Autores: Ernesto S. Nakayasu, Farooq Syed, Sarah A. Tersey, Marina A. Gritsenko, Hugh D. Mitchell, Chi Yuet Chan, Ercument Dirice, Jean-Valery Turatsinze, Yi Cui, Rohit N. Kulkarni, Decio L. Eizirik, Wei-Jun Qian, Bobbie-Jo M. Webb-Robertson, Carmella Evans-Molina, Raghavendra G. Mirmira., Thomas O. Metz
Publicado en: Cell Metabolism, Edición 31/2, 2020, Página(s) 363-374.e6, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2019.12.005

Angiotensin I-converting enzyme type 2 expression is increased in pancreatic islets of type 2 diabetic donors

Autores: Fignani D, Pedace E, Licata G, Grieco GE, Aiello E, de Luca C, Marselli L, Marchetti P, Sebastiani G, Dotta F
Publicado en: Diabetes/metabolism research and reviews, Edición 39(8), 2023, Página(s) e3696, ISSN 1520-7560
Editor: Wiley-Blackwell
DOI: 10.1002/dmrr.3696

IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity

Autores: Thomaidou S, Munoz Garcia A, de Lange S, Gan J, van der Slik AR, Hoeben RC, Roep BO, Carlotti F, Zaldumbide A
Publicado en: Diabetologia, Edición 66(11), 2023, Página(s) 2075-2086, ISSN 0012-186X
Editor: Springer Verlag
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100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention

Autores: Ziegler AG, Danne T, Daniel C, Bonifacio E.
Publicado en: Med, Edición 2(10), 2021, Página(s) 1120-1137, ISSN 2666-6340
Editor: Cell Press
DOI: 10.1016/j.medj.2021.08.003

Bioluminescent reporter assay for monitoring ER stress in human beta cells

Autores: Maria J. L. Kracht, Eelco J. P. de Koning, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
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Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?

Autores: Deligne C, You S, Mallone R.
Publicado en: Journal of Personalized Medicine, Edición 12(4):, 2022, Página(s) 543, ISSN 2075-4426
Editor: Basel, Switzerland : MDPI AG, 2011-
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Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis.

Autores: Szymczak F, Colli ML, Mamula MJ, Evans-Molina C, Eizirik DL.
Publicado en: Science Advances, Edición 7(2), 2021, Página(s) eabd7600, ISSN 2375-2548
Editor: Washington, DC : American Association for the Advancement of Science
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Noninvasive Monitoring of Glycemia-Induced Regulation of GLP-1R Expression in Murine and Human Islets of Langerhans.

Autores: Buitinga M, Cohrs CM, Eter WA, Claessens-Joosten L, Frielink C, Bos D, Sandker G, Brom M, Speier S, Gotthardt M.
Publicado en: Diabetes, Edición 69(11), 2021, Página(s) 2246-2252, ISSN 0012-1797
Editor: American Diabetes Association
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Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes.

Autores: Nigi L, Brusco N, Grieco GE, Licata G, Krogvold L, Marselli L, Gysemans C, Overbergh L, Marchetti P, Mathieu C, Dahl Jørgensen K, Sebastiani G, Dotta F.
Publicado en: Frontiers in Endocrinology, Edición 11:630, 2020, ISSN 1664-2392
Editor: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.00630

Family Structure is Associated with Mental Health and Attention Deficit (Hyperactivity) Disorders in Adolescents with Type 1 Diabetes

Autores: Baechle C, Stahl-Pehe A, Castillo K, Holl RW, Rosenbauer J.
Publicado en: Experimental and Clinical Endocrinology and Diabetes, Edición 130(9), 2022, Página(s) 604-613, ISSN 0947-7349
Editor: Johann Ambrosius Barth
DOI: 10.1055/a-1729-7972

The challenge of modulating β-cell autoimmunity in type 1 diabetes

Autores: Mark A Atkinson, Bart O Roep, Amanda Posgai, Daniel C S Wheeler, Mark Peakman
Publicado en: The Lancet Diabetes & Endocrinology, Edición 7/1, 2019, Página(s) 52-64, ISSN 2213-8587
Editor: Elsevier BV
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EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion

Autores: Blanchi B, Taurand M, Colace C, Thomaidou S, Audeoud C, Fantuzzi F, Sawatani T, Gheibi S, Sabadell-Basallote J, Boot FWJ, Chantier T, Piet A, Cavanihac C, Pilette M, Balguerie A, Olleik H, Carlotti F, Ejarque M, Fex M, Mulder H, Cnop M, Eizirik DL, Jouannot O, Gaffuri AL, Czernichow P, Zaldumbide A, Scharfmann R, Ravassard P
Publicado en: Molecular metabolism, Edición 76, 2023, Página(s) 76:101772, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101772

Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas.

Autores: Brusko TM, Mallone R, Rodriguez-Calvo T.
Publicado en: Frontiers in endocrinology., Edición 12:767012, 2021, ISSN 1664-2392
Editor: Frontiers Research Foundation
DOI: 10.3389/fendo.2021.767012

Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes

Autores: Alexandra Coomans de Brachène, Angela Castela, Anne Op de Beeck, Raghavendra G. Mirmira, Lorella Marselli, Piero Marchetti, Craig Masse, Wenyan Miao, Silvana Leit, Carmella Evans‐Molina, Decio L. Eizirik
Publicado en: Diabetes, Obesity and Metabolism, Edición 2020-06, 2020, ISSN 1462-8902
Editor: Blackwell Publishing Inc.
DOI: 10.1111/dom.14104

Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors.

Autores: Nigi L, Brusco N, Grieco GE, Fignani D, Licata G, Formichi C, Aiello E, Marselli L, Marchetti P, Krogvold L, Jorgensen KD, Sebastiani G, Dotta F.
Publicado en: Frontiers in immunology., Edición 13: 833141, 2022, ISSN 1664-3224
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.833141

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects.

Autores: Arif S, Pujol-Autonell I, Kamra Y, Williams E, Yusuf N, Domingo-Vila C, Shahrabi Y, Pollock E, Khatri L, Peakman M, Tree T, Lorenc A.
Publicado en: Frontiers in immunology, Edición 12:675746, 2021, ISSN 1664-3224
Editor: Frontiers Research Foundation
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Continuous Glucose Monitoring-Derived Data Report-Simply a Better Management Tool.

Autores: Battelino T, Bergenstal RM.
Publicado en: Diabetes Care, 2020, ISSN 0149-5992
Editor: American Diabetes Association
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The pancreatic β cell response to secretory demands and adaption to stress.

Autores: Kalwat MA, Scheuner D, Rodrigues Dos Santos K, Eizirik DL, Cobb MH.
Publicado en: Endocrinology, Edición 162(11), 2021, Página(s) bqab173, ISSN 0013-7227
Editor: The Endocrine Society
DOI: 10.1210/endocr/bqab173

The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes

Autores: Russell MA, Richardson SJ, Morgan NG
Publicado en: Frontiers in endocrinology, Edición 14, 2023, Página(s) 1270325, ISSN 1664-2392
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2023.1270325

A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets.

Autores: Kaur S, Mirza AH, Overgaard AJ, Pociot F, Størling J.
Publicado en: Frontiers in genetics., Edición 12:630109, 2021, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2021.630109

Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples.

Autores: Grieco GE, Sebastiani G, Fignani D, Brusco N, Nigi L, Formichi C, Licata G, Bruttini M, D'Aurizio R, Mathieu C, Gysemans C, Dotta F.
Publicado en: STAR protocols, Edición 2(3), 2021, Página(s) 100606, ISSN 2666-1667
Editor: [Cambridge, MA] : Cell Press,
DOI: 10.1016/j.xpro.2021.100606

Tryptophan metabolism promotes immune evasion in human pancreatic β cells

Autores: Rachdi L, Zhou Z, Berthault C, Lourenço C, Fouque A, Domet T, Armanet M, You S, Peakman M, Mallone R, Scharfmann R.
Publicado en: EBioMedicine, Edición 95, 2023, Página(s) 104740, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104740

Gene expression signature predicts rate of type 1 diabetes progression

Autores: Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium
Publicado en: EBioMedicine, Edición 92, 2023, Página(s) 92:104625, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104625

Nanoencapsulated human pancreatic islets for β-cell replacement in Type 1 diabetes

Autores: Silke Krol, Walter Baronti, Piero Marchetti
Publicado en: Nanomedicine, Edición 15/18, 2020, Página(s) 1735-1738, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm-2020-0166

Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation.

Autores: Grieco GE, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F.
Publicado en: Cell death discovery., Edición 8, 2022, Página(s) 340, ISSN 2058-7716
Editor: New York, NY] : Nature Publishing Group, [2015]
DOI: 10.1038/s41420-022-01142-x

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.

Autores: Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium.
Publicado en: Trials, Edición 23, 2022, Página(s) 414, ISSN 1745-6215
Editor: BioMed Central
DOI: 10.1186/s13063-022-06259-z

Importance of beta cell mass for glycaemic control in people with type 1 diabetes.

Autores: Jansen TJP, Brom M, Boss M, Buitinga M, Tack CJ, van Meijel LA, de Galan BE, Gotthardt M.
Publicado en: Diabetologia, Edición 1–9., 2022, ISSN 1432-0428
Editor: Berlin Springer Verlag
DOI: 10.1007/s00125-022-05830-2

Frequency and Characteristics of MODY 1 (HNF4A Mutation) and MODY 5 (HNF1B Mutation): Analysis From the DPV Database

Autores: Katharina Warncke, Sebastian Kummer, Klemens Raile, Jürgen Grulich-Henn, Joachim Woelfle, Elisabeth Steichen, Nicole Prinz, Reinhard W Holl
Publicado en: The Journal of Clinical Endocrinology & Metabolism, Edición 104/3, 2018, Página(s) 845-855, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/jc.2018-01696

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

Autores: Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.
Publicado en: Diabetes Care, Edición 43(1), 2022, Página(s) 5-12, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc19-0880

A circular RNA generated from an intron of the insulin gene controls insulin secretion

Autores: Lisa Stoll, Adriana Rodríguez-Trejo, Claudiane Guay, Flora Brozzi, Mustafa Bilal Bayazit, Sonia Gattesco, Véronique Menoud, Jonathan Sobel, Ana Claudia Marques, Morten Trillingsgaard Venø, Jonathan Lou S. Esguerra, Mohammad Barghouth, Mara Suleiman, Lorella Marselli, Jørgen Kjems, Lena Eliasson, Erik Renström, Karim Bouzakri, Michel Pinget, Piero Marchetti, Romano Regazzi
Publicado en: Nature Communications, Edición 11/1, 2020, Página(s) 11(1):5611, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19381-w

IL-2-based approaches to Treg enhancement

Autores: Harris F, Berdugo YA, Tree T.
Publicado en: Clinical and experimental immunology, Edición 211(2), 2023, Página(s) 149–163, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxac105

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells.

Autores: Müller A, Schmidt D, Xu CS, Pang S, D'Costa JV, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M.
Publicado en: The Journal of cell biology., Edición 220(2), 2021, Página(s) e202010039, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202010039

Klf6 protects β-cells against insulin resistance-induced dedifferentiation

Autores: Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Publicado en: Molecular Metabolism, Edición 35, 2020, Página(s) 100958, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.02.001

Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes.

Autores: Masini M, Suleiman M, Novelli M, Marselli L, Marchetti P, De Tata V.
Publicado en: Cells, Edición 10(8), 2021, Página(s) 1875, ISSN 2073-4409
Editor: Basel, Switzerland : MDPI
DOI: 10.3390/cells10081875

Temporal regulation of interferon signalling in human EndoC-βH1 cells.

Autores: Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG.
Publicado en: Journal of molecular endocrinology., Edición 69(2), 2022, Página(s) 299–313, ISSN 1479-6813
Editor: Bristol, U.K. : Journal of Endocrinology, Ltd., c1988-
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Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets

Autores: Simranjeet Kaur, Aashiq Mirza, Flemming Pociot
Publicado en: Non-Coding RNA, Edición 4/4, 2018, Página(s) 38, ISSN 2311-553X
Editor: MDPI
DOI: 10.3390/ncrna4040038

Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing

Autores: Stephane Demine, Michael L. Schulte, Paul R. Territo, Decio L. Eizirik
Publicado en: International Journal of Molecular Sciences, Edición 21/19, 2020, Página(s) 7274, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197274

A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion

Autores: Dassine Berdous, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Maxime Jan, Clara Roujeau, Isabel C. Lopez-Mejia, Randall Mynatt, Bernard Thorens
Publicado en: Molecular Metabolism, Edición 37, 2020, Página(s) 100993, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.100993

Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial

Autores: Krogvold L, Mynarek IM, Ponzi E, Mørk FB, Hessel TW, Roald T, Lindblom N, Westman J, Barker P, Hyöty H, Ludvigsson J, Hanssen KF, Johannesen J, Dahl-Jørgensen K
Publicado en: Nature medicine, Edición 29(11), 2023, Página(s) 2902-2908, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-023-02576-1

Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.

Autores: Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R.
Publicado en: Diabetes, Edición 69(12), 2020, Página(s) 2678-2690, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db20-0013

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.

Autores: Corcos N, Culina S, Deligne C, Lavaud C, You S, Mallone R.
Publicado en: Frontiers in immunology, 2021, Página(s) 12:616215, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.616215

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Autores: Eddie A. James, Roberto Mallone, Sally C. Kent, Teresa P. DiLorenzo
Publicado en: Diabetes, Edición 69/7, 2020, Página(s) 1311-1335, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/dbi19-0022

MiR‐375‐mediated suppression of engineered coxsackievirus B3 in pancreatic cells

Autores: Markian Pryshliak, Ahmet Hazini, Klaus Knoch, Babette Dieringer, Beatrice Tolksdorf, Michele Solimena, Jens Kurreck, Sandra Pinkert, Henry Fechner
Publicado en: FEBS Letters, Edición 594/4, 2020, Página(s) 763-775, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.13647

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Autores: Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
Publicado en: Diabetes, Edición 66/1, 2016, Página(s) 100-112, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db16-0592

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Autores: Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Publicado en: Journal of Biological Chemistry, Edición 292/36, 2017, Página(s) 14977-14988, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.769877

New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

Autores: James Harbige, Martin Eichmann, Mark Peakman
Publicado en: Journal of Autoimmunity, Edición 84, 2017, Página(s) 12-20, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2017.08.001

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Autores: Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo
Publicado en: Diabetes, Edición 66/9, 2017, Página(s) 2446-2458, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db16-1252

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Autores: Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
Publicado en: Diabetologia, Edición 60/4, 2017, Página(s) 656-667, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-016-4201-3

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis

Autores: Reinaldo S Dos Santos, Laura Marroqui, Fabio A Grieco, Lorella Marselli, Mara Suleiman, Stefan R Henz, Piero Marchetti, Rasmus Wernersson, Decio L Eizirik
Publicado en: Endocrinology, Edición 158/8, 2017, Página(s) 2503-2521, ISSN 0013-7227
Editor: The Endocrine Society
DOI: 10.1210/en.2017-00104

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

Autores: Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Publicado en: Journal of Clinical Investigation, Edición 128/8, 2018, Página(s) 3460-3474, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI120555

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

Autores: Niina Lietzén, Lu Cheng, Robert Moulder, Heli Siljander, Essi Laajala, Taina Härkönen, Aleksandr Peet, Aki Vehtari, Vallo Tillmann, Mikael Knip, Harri Lähdesmäki, Riitta Lahesmaa
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-24019-5

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Autores: Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Publicado en: Diabetes, Edición 67/11, 2018, Página(s) 2337-2348, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db18-0295

Immunological biomarkers for the development and progression of type 1 diabetes

Autores: Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Publicado en: Diabetologia, Edición 61/11, 2018, Página(s) 2252-2258, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-018-4726-8

When one becomes many-Alternative splicing in β-cell function and failure

Autores: Maria Inês Alvelos, Jonàs Juan-Mateu, Maikel Luis Colli, Jean-Valéry Turatsinze, Décio L. Eizirik
Publicado en: Diabetes, Obesity and Metabolism, Edición 20, 2018, Página(s) 77-87, ISSN 1462-8902
Editor: Blackwell Publishing Inc.
DOI: 10.1111/dom.13388

Biomarkers of islet beta cell stress and death in type 1 diabetes

Autores: Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira
Publicado en: Diabetologia, Edición 61/11, 2018, Página(s) 2259-2265, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-018-4712-1

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Autores: Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Publicado en: Molecules, Edición 23/9, 2018, Página(s) 2100, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23092100

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Autores: Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Publicado en: EBioMedicine, Edición 36, 2018, Página(s) 367-375, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2018.09.040

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Autores: Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Publicado en: Diabetes, Edición 67/3, 2018, Página(s) 423-436, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db17-0736

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Autores: Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik
Publicado en: Diabetologia, Edición 61/3, 2018, Página(s) 636-640, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-017-4536-4

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Autores: Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Publicado en: The FASEB Journal, Edición 32/3, 2018, Página(s) 1524-1536, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700710R

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells

Autores: Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-15417-2

Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

Autores: Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger
Publicado en: The Journal of Clinical Endocrinology & Metabolism, Edición 103/9, 2018, Página(s) 3350-3358, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/jc.2018-00500

Europe has to step up its efforts to produce innovative and safe diabetes technology

Autores: Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Publicado en: Diabetologia, Edición 60/12, 2017, Página(s) 2532-2533, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-017-4455-4

MicroRNAs

Autores: Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese
Publicado en: Current Opinion in Endocrinology & Diabetes and Obesity, Edición 25/4, 2018, Página(s) 237-245, ISSN 1752-296X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MED.0000000000000420

Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Autores: Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Fr
Publicado en: Science Immunology, Edición 3/20, 2018, Página(s) eaao4013, ISSN 2470-9468
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aao4013

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Autores: Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia Carré, Sheena Pinto, Slobodan Culina, Noémie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, Søren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, G
Publicado en: Cell Metabolism, Edición 28/6, 2018, Página(s) 946-960.e6, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2018.07.007

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

Autores: Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina
Publicado en: Current Diabetes Reports, Edición 18/11, 2018, ISSN 1534-4827
Editor: Current Science Inc.
DOI: 10.1007/s11892-018-1083-4

Virus-like infection induces human β cell dedifferentiation

Autores: Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann
Publicado en: JCI Insight, Edición 3/3, 2018, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.97732

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Autores: Piero Marchetti, Mara Suleiman, Lorella Marselli
Publicado en: Diabetologia, Edición 61/4, 2018, Página(s) 770-774, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-018-4546-x

MANF protects human pancreatic beta cells against stress-induced cell death

Autores: Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Päivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutškov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski
Publicado en: Diabetologia, Edición 61/10, 2018, Página(s) 2202-2214, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-018-4687-y

Novel minor HLA DR associated antigens in type 1 diabetes

Autores: Denise Müller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio
Publicado en: Clinical Immunology, Edición 194, 2018, Página(s) 87-91, ISSN 1521-6616
Editor: Academic Press
DOI: 10.1016/j.clim.2018.07.001

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

Autores: Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, Jürgen Enczmann, Thomas Meissner
Publicado en: Genes, Edición 8/5, 2017, Página(s) 146, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes8050146

DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway

Autores: Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis Castaño, Izortze Santin
Publicado en: Diabetologia, 2018, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-018-4782-0

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Autores: Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Publicado en: eLife, Edición 7, 2018, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.38519

Understanding type 1 diabetes through proteomics

Autores: Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
Publicado en: Expert Review of Proteomics, Edición 14/7, 2017, Página(s) 571-580, ISSN 1478-9450
Editor: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1345633

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

Autores: Saurabh Vig, Mijke Buitinga, Dieter Rondas, Inne Crèvecoeur, Marc van Zandvoort, Etienne Waelkens, Decio L. Eizirik, Conny Gysemans, Pieter Baatsen, Chantal Mathieu, Lut Overbergh
Publicado en: Cell Death & Disease, Edición 10/4, 2019, Página(s) 309, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-019-1518-0

Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials

Autores: Jessica S. Suwandi, Tatjana Nikolic, Bart O. Roep
Publicado en: Frontiers in Immunology, Edición 8, 2017, Página(s) 1598, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2017.01598

Fostering improved human islet research: a European perspective

Autores: Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Publicado en: Diabetologia, Edición 62/8, 2019, Página(s) 1514-1516, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Autores: Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Publicado en: Molecular Metabolism, Edición 24, 2019, Página(s) 98-107, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

Autores: Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti
Publicado en: Molecular and Cellular Endocrinology, Edición 473, 2018, Página(s) 186-193, ISSN 0303-7207
Editor: Elsevier BV
DOI: 10.1016/j.mce.2018.01.019

Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach

Autores: Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl
Publicado en: Diabetes Care, Edición 40/3, 2017, Página(s) 309-316, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc16-1625

Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort

Autores: Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl
Publicado en: Experimental and Clinical Endocrinology & Diabetes, Edición 125/10, 2017, Página(s) 661-668, ISSN 0947-7349
Editor: Johann Ambrosius Barth
DOI: 10.1055/s-0043-104701

Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization

Autores: Subhash K. Tripathi, Tommi Välikangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa
Publicado en: iScience, Edición 11, 2019, Página(s) 334-355, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2018.12.020

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Autores: Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Publicado en: Journal of Innate Immunity, Edición 11/4, 2019, Página(s) 375-390, ISSN 1662-811X
Editor: Karger AG
DOI: 10.1159/000496034

Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

Autores: Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin Béhé, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt
Publicado en: Journal of Nuclear Medicine, Edición 60/6, 2019, Página(s) 812-816, ISSN 0161-5505
Editor: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.219980

Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells

Autores: Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa
Publicado en: iScience, Edición 19, 2019, Página(s) 340-357, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2019.07.040

ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor

Autores: Pamela L. Toledo, Juha M. Torkko, Andreas Müller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Publicado en: Journal of Biological Chemistry, Edición 294/21, 2019, Página(s) 8564-8576, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.007607

Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative

Autores: Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl
Publicado en: Pediatric Diabetes, Edición 19/7, 2018, Página(s) 1271-1275, ISSN 1399-543X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12711

The supply chain of human pancreatic β cell lines

Autores: Raphael Scharfmann, Willem Staels, Olivier Albagli
Publicado en: Journal of Clinical Investigation, Edición 129/9, 2019, Página(s) 3511-3520, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci129484

The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Autores: Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio Eizirik
Publicado en: Journal of Molecular Endocrinology, 2019, ISSN 0952-5041
Editor: Society for Endocrinology
DOI: 10.1530/jme-19-0066

Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration

Autores: Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
Publicado en: Pediatric Diabetes, Edición 20/3, 2019, Página(s) 282-285, ISSN 1399-543X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12816

MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

Autores: Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Publicado en: International Journal of Molecular Sciences, Edición 19/12, 2018, Página(s) 3705, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19123705

Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg

Autores: Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl
Publicado en: Pediatric Diabetes, Edición 19/5, 2018, Página(s) 937-944, ISSN 1399-543X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12656

Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

Autores: Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
Publicado en: Diabetologia, Edición 62/8, 2019, Página(s) 1329-1336, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-019-4908-z

Risk factors for decline in renal function among young adults with type 1 diabetes

Autores: Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl
Publicado en: Journal of Diabetes and its Complications, Edición 32/10, 2018, Página(s) 940-946, ISSN 1056-8727
Editor: Elsevier BV
DOI: 10.1016/j.jdiacomp.2018.07.007

Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry

Autores: Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl
Publicado en: The Journal of Pediatrics, Edición 201, 2018, Página(s) 78-85.e4, ISSN 0022-3476
Editor: Mosby Inc.
DOI: 10.1016/j.jpeds.2018.05.014

Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue

Autores: Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell
Publicado en: International Journal of Mass Spectrometry, Edición 437, 2019, Página(s) 10-16, ISSN 1387-3806
Editor: Elsevier BV
DOI: 10.1016/j.ijms.2017.11.001

Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Autores: Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl
Publicado en: Diabetologia, Edición 61/6, 2018, Página(s) 1354-1361, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-018-4580-8

Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries

Autores: Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-Jørgensen, Elke Froehlich-Reiterer, Maria
Publicado en: Diabetes Care, Edición 42/3, 2019, Página(s) e37-e39, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc18-1253

CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases

Autores: Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi
Publicado en: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.007

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Autores: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
Publicado en: Cell, Edición 176/4, 2019, Página(s) 882-896.e18, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2018.11.044

The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

Autores: Ernesto S. Nakayasu, Wei-Jun Qian, Carmella Evans-Molina, Raghavendra G. Mirmira, Decio L. Eizirik, Thomas O. Metz
Publicado en: Expert Review of Proteomics, Edición 16/7, 2019, Página(s) 569-582, ISSN 1478-9450
Editor: Future Drugs Ltd.
DOI: 10.1080/14789450.2019.1634548

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Autores: Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Publicado en: Nature Genetics, Edición 51/11, 2019, Página(s) 1588-1595, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-019-0524-6

miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

Autores: Giuliana Ventriglia, Francesca Mancarella, Guido Sebastiani, Dana P. Cook, Roberto Mallone, Chantal Mathieu, Conny Gysemans, Francesco Dotta
Publicado en: Diabetologia, 2019, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-019-05026-1

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

Autores: Johan Verhagen, Norkhairin Yusuf, Emma L. Smith, Emily M. Whettlock, Kerina Naran, Sefina Arif, Mark Peakman
Publicado en: Diabetologia, Edición 62/12, 2019, Página(s) 2252-2261, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-019-04994-8

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs

Autores: Aashiq H. Mirza, Simranjeet Kaur, Lotte B. Nielsen, Joachim Størling, Reza Yarani, Martin Roursgaard, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Henrik B. Mortensen, Flemming Pociot
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02543

Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Autores: Tine Tesovnik, Jernej Kovac, Tinka Hovnik, Klemen Dovc, Nataša Bratina, Tadej Battelino, Katarina Trebušak Podkrajšek
Publicado en: JAMA Pediatrics, Edición 172/9, 2018, Página(s) 879, ISSN 2168-6203
Editor: American Medical Association
DOI: 10.1001/jamapediatrics.2018.1175

Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry

Autores: Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02547

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Autores: Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Publicado en: Stem Cell Research & Therapy, Edición 11/1, 2020, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-019-1523-3

From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

Autores: Laura Nigi, Carla Maccora, Francesco Dotta, Guido Sebastiani
Publicado en: Diabetes/Metabolism Research and Reviews, 2019, ISSN 1520-7552
Editor: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3264

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Autores: Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Laura Nigi, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Publicado en: International Journal of Molecular Sciences, Edición 20/24, 2019, Página(s) 6358, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20246358

Capturing residual beta cell function in type 1 diabetes

Autores: Pociot F
Publicado en: Diabetologia, Edición 2019 Jan;62(1), 2019, Página(s) 28-32, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-018-4768-y

PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging

Autores: Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M
Publicado en: The Journal of Nuclear Medicine, Edición 2020 Jan; 61(1), 2019, Página(s) 112–116, ISSN 0161-5505
Editor: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.228627

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

Autores: Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M
Publicado en: Clinical and Experimental Immunology, Edición 2019 Oct 29, 2019, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cei.13391

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Autores: Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Publicado en: Diabetologia, Edición 63/2, 2020, Página(s) 395-409, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities

Autores: Halliez C, Ibrahim H, Otonkoski T, Mallone R.
Publicado en: Frontiers in endocrinology, Edición 13, 2023, Página(s) 13:1076683, ISSN 1664-2392
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.1076683

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.

Autores: Fernanda M. C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Publicado en: Diabetes, 2020, Página(s) db200421, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db20-0421

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes

Autores: Van Rampelbergh J, Achenbach P, Leslie RD, Ali MA, Dayan C, Keymeulen B, Owen KR, Kindermans M, Parmentier F, Carlier V, Ahangarani RR, Gebruers E, Bovy N, Vanderelst L, Van Mechelen M, Vandepapelière P, Boitard C.
Publicado en: BMC medicine, Edición 21(1), 2023, Página(s) 190, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-023-02900-z

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells

Autores: Berthault C, Staels W, Scharfmann R.
Publicado en: Molecular Metabolism, Edición 2020 Aug 4:101060, 2020, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101060

Long-RNA sequencing and ribosome profiling of inflamed beta-cells reveal an extensive translatome landscape.

Autores: Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, 't Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A.
Publicado en: Diabetes, Edición 70(10), 2021, Página(s) 2299-2312, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db20-1122

Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.

Autores: Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A.
Publicado en: Immunology, Edición 166(1), 2022, Página(s) 121-137, ISSN 1365-2567
Editor: Oxford : Blackwell Scientific Publications
DOI: 10.1111/imm.13460

ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis.

Autores: Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A.
Publicado en: Frontiers in endocrinology., Edición 13, 2022, Página(s) 991632, ISSN 1664-2392
Editor: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.991632

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Autores: Roberto Mallone, Decio L. Eizirik
Publicado en: Diabetologia, Edición 63/10, 2020, Página(s) 1999-2006, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-020-05176-7

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

Autores: Marwaha AK, Chow S, Pesenacker AM, Cook L, Sun A, Long SA, Yang JHM, Ward-Hartstonge KA, Williams E, Domingo-Vila C, Halani K, Harris KM, Tree TIM, Levings MK, Elliott T, Tan R, Dutz JP.
Publicado en: Immunotherapy Advances, 2021, Página(s) 2(1), ISSN 2732-4303
Editor: Oxford University Press
DOI: 10.1093/immadv/ltab022

The Transatlantic HbA1c gap : differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry

Autores: Hermann, Julia M.; Miller, K. M.; Hofer, S. E.; Clements, M. A.; Karges, Wolfram; Foster, N. C.; Fröhlich-Reiterer, E.; Rickels, M. R.; Rosenbauer, J.; DeSalvo, D. J.; Holl, R. W.; Maahs, D. M.
Publicado en: Diabetic medicine (2019). doi:10.1111/dme.14148, Edición 1, 2020, ISSN 1464-5491
Editor: Wiley
DOI: 10.18154/RWTH-2020-01942

Glycemic variability - the danger of a physiologically stable metric.

Autores: Battelino T, Dovč K.
Publicado en: The Journal of clinical endocrinology and metabolism., Edición 105(10), 2020, Página(s) e3815–e3817, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/clinem/dgaa486

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Autores: Sofia Thomaidou, Maria J.L. Kracht, Arno van der Slik, Sandra Laban, Eelco J. de Koning, Francoise Carlotti, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Publicado en: Diabetes, Edición 69/4, 2020, Página(s) 670-680, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db19-0984

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.

Autores: Eizirik DL, Szymczak F, Alvelos MI, Martin F.
Publicado en: Diabetes, Edición 70(9), 2021, Página(s) 1915-1925, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/dbi20-0046

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets.

Autores: Rodriguez-Calvo T, Johnson JD, Overbergh L, Dunne JL.
Publicado en: Frontiers in immunology, 2021, Página(s) 12:667989, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.667989

Defining a cure for type 1 diabetes: a call to action.

Autores: Roep BO, Montero E, van Tienhoven R, Atkinson MA, Schatz DA, Mathieu C.
Publicado en: The lancet. Diabetes & endocrinology, Edición (9), 2021, Página(s) 553-555, ISSN 2213-8587
Editor: Elsevier BV
DOI: 10.1016/s2213-8587(21)00181-9

Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors.

Autores: Diedisheim M, Dermine S, Jouinot A, Septier A, Gaujoux S, Dousset B, Cadiot G, Larger E, Bertherat J, Scharfmann R, Terris B, Coriat R, Assié G.
Publicado en: Endocrine-Related Cancer, Edición 28(8), 2021, Página(s) 563-571, ISSN 1351-0088
Editor: Society for Endocrinology
DOI: 10.1530/erc-21-0051

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

Autores: Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Fl
Publicado en: The lancet. Diabetes & endocrinology, Edición 11(9), 2023, Página(s) 657-666, ISSN 2213-8587
Editor: Elsevier BV
DOI: 10.1101/2023.08.19.553954

Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology.

Autores: Yang ML, Sodré FMC, Mamula MJ, Overbergh L.
Publicado en: Frontiers in immunology, Edición 12:678953, 2021, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.678953

A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice

Autores: Stéphane Demine, Rita Garcia Ribeiro, Julien Thevenet, Lorella Marselli, Piero Marchetti, François Pattou, Julie Kerr-Conte, Nick Devoogdt, Decio L. Eizirik
Publicado en: Diabetologia, Edición 63/4, 2020, Página(s) 825-836, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-019-05068-5

International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between 8 high-income countries but similar rise during adolescence-A quality registry study.

Autores: Anderzén J, Hermann JM, Samuelsson U, Charalampopoulos D, Svensson J, Skrivarhaug T, Fröhlich-Reiterer E, Maahs DM, Akesson K, Kapellen T, Fritsch M, Birkebaek NH, Drivvoll AK, Miller K, Stephenson T, Hofer SE, Fredheim S, Kummernes SJ, Foster N, Amin R, Hilgard D, Rami-Merhar B, Dahl-Jørgensen K, Clements M, Hanas R, Holl RW, Warner JT.
Publicado en: Pediatric diabetes., Edición 21(4), 2020, Página(s) 621-627, ISSN 1399-5448
Editor: Copenhagen : Munksgaard
DOI: 10.1111/pedi.13014

Monitoring beta cell survival after intrahepatic islet transplantation using dynamic exendin PET imaging: a proof-of-concept study in individuals with type 1 diabetes

Autores: Jansen TJP, Buitinga M, Boss M, Nijhoff MF, Brom M, de Galan BE, van der Graaf M, van Koeverden S, Vantyghem MC, Beron A, Pattou F, Engelse MA, Velikyan I, Eriksson O, de Koning EJP, Gotthardt M
Publicado en: Diabetes, Edición 72(7), 2023, Página(s) 898-907, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db22-0884

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Autores: Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P.
Publicado en: Cell reports., Edición 33(9), 2020, Página(s) 108466, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108466

NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins

Autores: Bissenova S, Ellis D, Callebaut A, Eelen G, Derua R, Buitinga M, Mathieu C, Gysemans C, Overbergh L
Publicado en: Cells, Edición 12(9), 2023, Página(s) 1319, ISSN 2073-4409
Editor: Basel, Switzerland : MDPI
DOI: 10.3390/cells12091319

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes.

Autores: Wilhelm-Benartzi CS, Miller SE, Bruggraber S, Picton D, Wilson M, Gatley K, Chhabra A, Marcovecchio ML, Hendriks AEJ, Morobé H, Chmura PJ, Bond S, Aschemeier-Fuchs B, Knip M, Tree T, Overbergh L, Pall J, Arnaud O, Haller MJ, Nitsche A, Schulte AM, Mathieu C, Mander A, Dunger D.
Publicado en: BMJ Open, Edición 11(12), 2021, Página(s) e053669, ISSN 2044-6055
Editor: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-053669

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.

Autores: Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M.
Publicado en: Frontiers in cell and developmental biology., Edición 10, 2022, Página(s) 967765, ISSN 2296-634X
Editor: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2022.967765

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.

Autores: Bosi E, Marchetti P, Rutter GA, Eizirik DL.
Publicado en: iScience, Edición 25(10), 2022, Página(s) 105056, ISSN 2589-0042
Editor: [Cambridge, MA] : Cell Press, [2018]-
DOI: 10.1016/j.isci.2022.105056

Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools.

Autores: Grieco GE, Fignani D, Formichi C, Nigi L, Licata G, Maccora C, Brusco N, Sebastiani G, Dotta F.
Publicado en: Frontiers in immunology., Edición 12:682948, 2021, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.682948

Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM

Autores: Decio L. Eizirik, Maikel L. Colli
Publicado en: Nature Reviews Endocrinology, Edición 16/11, 2020, Página(s) 611-612, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-020-00409-6

Costimulation Blockade Disrupts CD4+ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.

Autores: Eichmann M, Baptista R, Ellis RJ, Heck S, Peakman M, Beam CA.
Publicado en: Journal of Immunology, Edición 204(12), 2020, Página(s) 3129-3138, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1901439

Heterogeneity and endotypes in type 1 diabetes mellitus

Autores: Redondo MJ, Morgan NG
Publicado en: Nature reviews. Endocrinology, Edición 19(9), 2023, Página(s) 542-554, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-023-00853-0

The role of Interleukin-32 in autoimmunity.

Autores: de Albuquerque R, Komsi E, Starskaia I, Ullah U, Lahesmaa R.
Publicado en: Scandinavian journal of immunology., Edición 93(2), 2021, Página(s) e13012, ISSN 0300-9475
Editor: Blackwell Publishing Inc.
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Exendin-4 analogs in insulinoma theranostics

Autores: Tom.J.P. Jansen, Sanne.A.M. van Lith, Marti Boss, Maarten Brom, Lieke Joosten, Martin Béhé, Mijke Buitinga, Martin Gotthardt
Publicado en: Journal of Labelled Compounds and Radiopharmaceuticals, Edición 62/10, 2019, Página(s) 656-672, ISSN 0362-4803
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3750

A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes.

Autores: Achenbach P, Hippich M, Zapardiel-Gonzalo J, Karges B, Holl RW, Petrera A, Bonifacio E, Ziegler AG; DiMelli Study group and DPV Study group.
Publicado en: EBioMedicine., Edición 82, 2022, Página(s) 104118, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104118

Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies

Autores: Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Publicado en: iScience, Edición 25(11), 2022, Página(s) 105376, ISSN 2589-0042
Editor: [Cambridge, MA] : Cell Press, [2018]-
DOI: 10.1016/j.isci.2022.105376

Comparative characteristics of older people with type 1 diabetes treated with continuous subcutaneous insulin infusion or insulin injection therapy: data from the German/Austrian DPV registry

Autores: J. Grammes, E. Küstner, A. Dapp, M. Hummel, J.‐C. Kämmer, T. Kubiak, I. Schütz‐Fuhrmann, S. Zimny, E. Bollow, R.W. Holl
Publicado en: Diabetic Medicine, Edición 37/5, 2020, Página(s) 856-862, ISSN 0742-3071
Editor: Blackwell Publishing Inc.
DOI: 10.1111/dme.14218

The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection.

Autores: Grieco GE, Brusco N, Licata G, Fignani D, Formichi C, Nigi L, Sebastiani G, Dotta F.
Publicado en: International journal of molecular sciences., Edición 22(2), 2021, Página(s) 803, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
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Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC-MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra.

Autores: Callebaut A, Derua R, Vig S, Delong T, Mathieu C, Overbergh L.
Publicado en: Journal of Proteome Research, Edición 20(2), 2021, Página(s) 1405-1414, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00801

Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes

Autores: Tine Tesovnik, Jernej Kovač, Katka Pohar, Samo Hudoklin, Klemen Dovč, Nataša Bratina, Katarina Trebušak Podkrajšek, Maruša Debeljak, Peter Veranič, Emanuele Bosi, Lorenzo Piemonti, Alojz Ihan, Tadej Battelino
Publicado en: Frontiers in Cell and Developmental Biology, Edición 8, 2020, Página(s) 202, ISSN 2296-634X
Editor: Frontiers Media
DOI: 10.3389/fcell.2020.00202

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

Autores: Piero Marchetti, Mara Suleiman, Carmela De Luca, Walter Baronti, Emanuele Bosi, Marta Tesi, Lorella Marselli
Publicado en: Seminars in Cell & Developmental Biology, Edición 103, 2020, Página(s) 83-93, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2020.04.005

CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes

Autores: Azoury ME, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaut A, Giraud M, Irla M, Lalanne AI, Carre A, Afonso G, Zhou Z, Brandao B, Colli ML, Sebastiani G, Dotta F, Nakayma M, Eizirik DL, You S, Pinto S, Mamula MJ, Verdier Y, Vinh J, Buus S, Mathieu C, Overgergh Lut, Mallone R
Publicado en: Diabetes, Edición 70(12), 2021, Página(s) 2879-2891, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db21-0259

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age

Autores: Henna Kallionpää, Juhi Somani, Soile Tuomela, Ubaid Ullah, Rafael de Albuquerque, Tapio Lönnberg, Elina Komsi, Heli Siljander, Jarno Honkanen, Taina Härkönen, Aleksandr Peet, Vallo Tillmann, Vikash Chandra, Mahesh Kumar Anagandula, Gun Frisk, Timo Otonkoski, Omid Rasool, Riikka Lund, Harri Lähdesmäki, Mikael Knip, Riitta Lahesmaa
Publicado en: Diabetes, Edición 68/10, 2019, Página(s) 2024-2034, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db19-0287

High-Throughput Analysis of Neutrophil Extracellular Trap Levels in Subtypes of People with Type 1 Diabetes

Autores: Bissenova S, Buitinga M, Boesch M, Korf H, Casteels K, Teunkens A, Mathieu C, Gysemans C.
Publicado en: Biology, Edición 12(6), 2023, Página(s) 882, ISSN 2079-7737
Editor: MDPI
DOI: 10.3390/biology12060882

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.

Autores: Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL.
Publicado en: Diabetologia, Edición 1-11, 2022, ISSN 1432-0428
Editor: Berlin Springer Verlag
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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.

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Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes.

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The making of insulin in health and disease

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Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

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