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Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

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Publications

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Author(s): Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
Published in: Diabetes, Issue 66/1, 2016, Page(s) 100-112, ISSN 0012-1797
DOI: 10.2337/db16-0592

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Author(s): Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Published in: Journal of Biological Chemistry, Issue 292/36, 2017, Page(s) 14977-14988, ISSN 0021-9258
DOI: 10.1074/jbc.M116.769877

New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

Author(s): James Harbige, Martin Eichmann, Mark Peakman
Published in: Journal of Autoimmunity, Issue 84, 2017, Page(s) 12-20, ISSN 0896-8411
DOI: 10.1016/j.jaut.2017.08.001

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Author(s): Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo
Published in: Diabetes, Issue 66/9, 2017, Page(s) 2446-2458, ISSN 0012-1797
DOI: 10.2337/db16-1252

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Author(s): Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
Published in: Diabetologia, Issue 60/4, 2017, Page(s) 656-667, ISSN 0012-186X
DOI: 10.1007/s00125-016-4201-3

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis

Author(s): Reinaldo S Dos Santos, Laura Marroqui, Fabio A Grieco, Lorella Marselli, Mara Suleiman, Stefan R Henz, Piero Marchetti, Rasmus Wernersson, Decio L Eizirik
Published in: Endocrinology, Issue 158/8, 2017, Page(s) 2503-2521, ISSN 0013-7227
DOI: 10.1210/en.2017-00104

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

Author(s): Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Published in: Journal of Clinical Investigation, Issue 128/8, 2018, Page(s) 3460-3474, ISSN 0021-9738
DOI: 10.1172/JCI120555

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

Author(s): Niina Lietzén, Lu Cheng, Robert Moulder, Heli Siljander, Essi Laajala, Taina Härkönen, Aleksandr Peet, Aki Vehtari, Vallo Tillmann, Mikael Knip, Harri Lähdesmäki, Riitta Lahesmaa
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-24019-5

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Author(s): Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Published in: Diabetes, Issue 67/11, 2018, Page(s) 2337-2348, ISSN 0012-1797
DOI: 10.2337/db18-0295

Immunological biomarkers for the development and progression of type 1 diabetes

Author(s): Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Published in: Diabetologia, Issue 61/11, 2018, Page(s) 2252-2258, ISSN 0012-186X
DOI: 10.1007/s00125-018-4726-8

When one becomes many-Alternative splicing in β-cell function and failure

Author(s): Maria Inês Alvelos, Jonàs Juan-Mateu, Maikel Luis Colli, Jean-Valéry Turatsinze, Décio L. Eizirik
Published in: Diabetes, Obesity and Metabolism, Issue 20, 2018, Page(s) 77-87, ISSN 1462-8902
DOI: 10.1111/dom.13388

Biomarkers of islet beta cell stress and death in type 1 diabetes

Author(s): Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira
Published in: Diabetologia, Issue 61/11, 2018, Page(s) 2259-2265, ISSN 0012-186X
DOI: 10.1007/s00125-018-4712-1

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Author(s): Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Published in: Molecules, Issue 23/9, 2018, Page(s) 2100, ISSN 1420-3049
DOI: 10.3390/molecules23092100

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Author(s): Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Published in: EBioMedicine, Issue 36, 2018, Page(s) 367-375, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2018.09.040

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Author(s): Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Published in: Diabetes, Issue 67/3, 2018, Page(s) 423-436, ISSN 0012-1797
DOI: 10.2337/db17-0736

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Author(s): Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik
Published in: Diabetologia, Issue 61/3, 2018, Page(s) 636-640, ISSN 0012-186X
DOI: 10.1007/s00125-017-4536-4

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Author(s): Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Published in: The FASEB Journal, Issue 32/3, 2018, Page(s) 1524-1536, ISSN 0892-6638
DOI: 10.1096/fj.201700710R

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells

Author(s): Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-15417-2

Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

Author(s): Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 103/9, 2018, Page(s) 3350-3358, ISSN 0021-972X
DOI: 10.1210/jc.2018-00500

Europe has to step up its efforts to produce innovative and safe diabetes technology

Author(s): Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Published in: Diabetologia, Issue 60/12, 2017, Page(s) 2532-2533, ISSN 0012-186X
DOI: 10.1007/s00125-017-4455-4

MicroRNAs

Author(s): Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese
Published in: Current Opinion in Endocrinology & Diabetes and Obesity, Issue 25/4, 2018, Page(s) 237-245, ISSN 1752-296X
DOI: 10.1097/MED.0000000000000420

Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Author(s): Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Fr
Published in: Science Immunology, Issue 3/20, 2018, Page(s) eaao4013, ISSN 2470-9468
DOI: 10.1126/sciimmunol.aao4013

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Author(s): Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia Carré, Sheena Pinto, Slobodan Culina, Noémie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, Søren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, G
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 946-960.e6, ISSN 1550-4131
DOI: 10.1016/j.cmet.2018.07.007

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

Author(s): Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina
Published in: Current Diabetes Reports, Issue 18/11, 2018, ISSN 1534-4827
DOI: 10.1007/s11892-018-1083-4

Virus-like infection induces human β cell dedifferentiation

Author(s): Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann
Published in: JCI Insight, Issue 3/3, 2018, ISSN 2379-3708
DOI: 10.1172/jci.insight.97732

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Author(s): Piero Marchetti, Mara Suleiman, Lorella Marselli
Published in: Diabetologia, Issue 61/4, 2018, Page(s) 770-774, ISSN 0012-186X
DOI: 10.1007/s00125-018-4546-x

MANF protects human pancreatic beta cells against stress-induced cell death

Author(s): Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Päivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutškov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski
Published in: Diabetologia, Issue 61/10, 2018, Page(s) 2202-2214, ISSN 0012-186X
DOI: 10.1007/s00125-018-4687-y

Novel minor HLA DR associated antigens in type 1 diabetes

Author(s): Denise Müller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio
Published in: Clinical Immunology, Issue 194, 2018, Page(s) 87-91, ISSN 1521-6616
DOI: 10.1016/j.clim.2018.07.001

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

Author(s): Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, Jürgen Enczmann, Thomas Meissner
Published in: Genes, Issue 8/5, 2017, Page(s) 146, ISSN 2073-4425
DOI: 10.3390/genes8050146

DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway

Author(s): Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis Castaño, Izortze Santin
Published in: Diabetologia, 2018, ISSN 0012-186X
DOI: 10.1007/s00125-018-4782-0

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Author(s): Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/elife.38519

Understanding type 1 diabetes through proteomics

Author(s): Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
Published in: Expert Review of Proteomics, Issue 14/7, 2017, Page(s) 571-580, ISSN 1478-9450
DOI: 10.1080/14789450.2017.1345633

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

Author(s): Saurabh Vig, Mijke Buitinga, Dieter Rondas, Inne Crèvecoeur, Marc van Zandvoort, Etienne Waelkens, Decio L. Eizirik, Conny Gysemans, Pieter Baatsen, Chantal Mathieu, Lut Overbergh
Published in: Cell Death & Disease, Issue 10/4, 2019, Page(s) 309, ISSN 2041-4889
DOI: 10.1038/s41419-019-1518-0

Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials

Author(s): Jessica S. Suwandi, Tatjana Nikolic, Bart O. Roep
Published in: Frontiers in Immunology, Issue 8, 2017, Page(s) 1598, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.01598

Fostering improved human islet research: a European perspective

Author(s): Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Published in: Diabetologia, Issue 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X
DOI: 10.1007/s00125-019-4911-4

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Author(s): Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Published in: Molecular Metabolism, Issue 24, 2019, Page(s) 98-107, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.03.004

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

Author(s): Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti
Published in: Molecular and Cellular Endocrinology, Issue 473, 2018, Page(s) 186-193, ISSN 0303-7207
DOI: 10.1016/j.mce.2018.01.019

Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach

Author(s): Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl
Published in: Diabetes Care, Issue 40/3, 2017, Page(s) 309-316, ISSN 0149-5992
DOI: 10.2337/dc16-1625

Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort

Author(s): Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl
Published in: Experimental and Clinical Endocrinology & Diabetes, Issue 125/10, 2017, Page(s) 661-668, ISSN 0947-7349
DOI: 10.1055/s-0043-104701

Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization

Author(s): Subhash K. Tripathi, Tommi Välikangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa
Published in: iScience, Issue 11, 2019, Page(s) 334-355, ISSN 2589-0042
DOI: 10.1016/j.isci.2018.12.020

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Author(s): Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Published in: Journal of Innate Immunity, Issue 11/4, 2019, Page(s) 375-390, ISSN 1662-811X
DOI: 10.1159/000496034

Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

Author(s): Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin Béhé, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt
Published in: Journal of Nuclear Medicine, Issue 60/6, 2019, Page(s) 812-816, ISSN 0161-5505
DOI: 10.2967/jnumed.118.219980

Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells

Author(s): Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa
Published in: iScience, Issue 19, 2019, Page(s) 340-357, ISSN 2589-0042
DOI: 10.1016/j.isci.2019.07.040

ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor

Author(s): Pamela L. Toledo, Juha M. Torkko, Andreas Müller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Published in: Journal of Biological Chemistry, Issue 294/21, 2019, Page(s) 8564-8576, ISSN 0021-9258
DOI: 10.1074/jbc.ra119.007607

Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative

Author(s): Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl
Published in: Pediatric Diabetes, Issue 19/7, 2018, Page(s) 1271-1275, ISSN 1399-543X
DOI: 10.1111/pedi.12711

The supply chain of human pancreatic β cell lines

Author(s): Raphael Scharfmann, Willem Staels, Olivier Albagli
Published in: Journal of Clinical Investigation, Issue 129/9, 2019, Page(s) 3511-3520, ISSN 0021-9738
DOI: 10.1172/jci129484

The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Author(s): Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio Eizirik
Published in: Journal of Molecular Endocrinology, 2019, ISSN 0952-5041
DOI: 10.1530/jme-19-0066

Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration

Author(s): Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
Published in: Pediatric Diabetes, Issue 20/3, 2019, Page(s) 282-285, ISSN 1399-543X
DOI: 10.1111/pedi.12816

MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

Author(s): Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Published in: International Journal of Molecular Sciences, Issue 19/12, 2018, Page(s) 3705, ISSN 1422-0067
DOI: 10.3390/ijms19123705

Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg

Author(s): Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl
Published in: Pediatric Diabetes, Issue 19/5, 2018, Page(s) 937-944, ISSN 1399-543X
DOI: 10.1111/pedi.12656

Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

Author(s): Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
Published in: Diabetologia, Issue 62/8, 2019, Page(s) 1329-1336, ISSN 0012-186X
DOI: 10.1007/s00125-019-4908-z

Risk factors for decline in renal function among young adults with type 1 diabetes

Author(s): Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl
Published in: Journal of Diabetes and its Complications, Issue 32/10, 2018, Page(s) 940-946, ISSN 1056-8727
DOI: 10.1016/j.jdiacomp.2018.07.007

Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry

Author(s): Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl
Published in: The Journal of Pediatrics, Issue 201, 2018, Page(s) 78-85.e4, ISSN 0022-3476
DOI: 10.1016/j.jpeds.2018.05.014

Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue

Author(s): Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell
Published in: International Journal of Mass Spectrometry, Issue 437, 2019, Page(s) 10-16, ISSN 1387-3806
DOI: 10.1016/j.ijms.2017.11.001

Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Author(s): Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl
Published in: Diabetologia, Issue 61/6, 2018, Page(s) 1354-1361, ISSN 0012-186X
DOI: 10.1007/s00125-018-4580-8

Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries

Author(s): Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-Jørgensen, Elke Froehlich-Reiterer, Maria
Published in: Diabetes Care, Issue 42/3, 2019, Page(s) e37-e39, ISSN 0149-5992
DOI: 10.2337/dc18-1253

CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases

Author(s): Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi
Published in: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
DOI: 10.1016/j.semcdb.2019.05.007

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Author(s): Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
Published in: Cell, Issue 176/4, 2019, Page(s) 882-896.e18, ISSN 0092-8674
DOI: 10.1016/j.cell.2018.11.044

The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

Author(s): Ernesto S. Nakayasu, Wei-Jun Qian, Carmella Evans-Molina, Raghavendra G. Mirmira, Decio L. Eizirik, Thomas O. Metz
Published in: Expert Review of Proteomics, Issue 16/7, 2019, Page(s) 569-582, ISSN 1478-9450
DOI: 10.1080/14789450.2019.1634548

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Author(s): Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Published in: Nature Genetics, Issue 51/11, 2019, Page(s) 1588-1595, ISSN 1061-4036
DOI: 10.1038/s41588-019-0524-6

miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

Author(s): Giuliana Ventriglia, Francesca Mancarella, Guido Sebastiani, Dana P. Cook, Roberto Mallone, Chantal Mathieu, Conny Gysemans, Francesco Dotta
Published in: Diabetologia, 2019, ISSN 0012-186X
DOI: 10.1007/s00125-019-05026-1

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

Author(s): Johan Verhagen, Norkhairin Yusuf, Emma L. Smith, Emily M. Whettlock, Kerina Naran, Sefina Arif, Mark Peakman
Published in: Diabetologia, Issue 62/12, 2019, Page(s) 2252-2261, ISSN 0012-186X
DOI: 10.1007/s00125-019-04994-8

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs

Author(s): Aashiq H. Mirza, Simranjeet Kaur, Lotte B. Nielsen, Joachim Størling, Reza Yarani, Martin Roursgaard, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Henrik B. Mortensen, Flemming Pociot
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.02543

Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Author(s): Tine Tesovnik, Jernej Kovac, Tinka Hovnik, Klemen Dovc, Nataša Bratina, Tadej Battelino, Katarina Trebušak Podkrajšek
Published in: JAMA Pediatrics, Issue 172/9, 2018, Page(s) 879, ISSN 2168-6203
DOI: 10.1001/jamapediatrics.2018.1175

Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry

Author(s): Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.02547

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Author(s): Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Published in: Stem Cell Research & Therapy, Issue 11/1, 2020, ISSN 1757-6512
DOI: 10.1186/s13287-019-1523-3

From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

Author(s): Laura Nigi, Carla Maccora, Francesco Dotta, Guido Sebastiani
Published in: Diabetes/Metabolism Research and Reviews, 2019, ISSN 1520-7552
DOI: 10.1002/dmrr.3264

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Author(s): Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Laura Nigi, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Published in: International Journal of Molecular Sciences, Issue 20/24, 2019, Page(s) 6358, ISSN 1422-0067
DOI: 10.3390/ijms20246358

Capturing residual beta cell function in type 1 diabetes

Author(s): Pociot F
Published in: Diabetologia, Issue 2019 Jan;62(1), 2019, Page(s) 28-32, ISSN 0012-186X
DOI: 10.1007/s00125-018-4768-y

PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging

Author(s): Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M
Published in: The Journal of Nuclear Medicine, Issue 2020 Jan; 61(1), 2019, Page(s) 112–116, ISSN 0161-5505
DOI: 10.2967/jnumed.119.228627

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

Author(s): Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M
Published in: Clinical and Experimental Immunology, Issue 2019 Oct 29, 2019, ISSN 0009-9104
DOI: 10.1111/cei.13391

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Author(s): Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Published in: Diabetologia, Issue 63/2, 2020, Page(s) 395-409, ISSN 0012-186X
DOI: 10.1007/s00125-019-05046-x