Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 | INNODIA | Project | Results | H2020 | CORDIS

Risultati finali

Characterization of the role for post- translational modifications, alternative splicing and endoplasmic reticulum stress for β-cell recognition by the immune system

Migration

Discovery and pre-clinical validation of novel biomarkers of β-cell mass, dysfunction and death in human T1D

Migration

A comprehensive pan-European research network for the study of the aetiology and prevention of T1D

Migration

Successful start-up of the project - Kick Off Meeting

Migration

EUnPOD functioning

Migration

Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D

Migration

Imaging tool for -cell inflammation/death

Migration

Development of novel approaches for in vivo β-cell imaging

Migration

Plan for access to the CTN by third parties

Migration

Novel models of the cross talk between human β-cells and the human system in vitro

Migration

Discovery analysis of novel biomarkers in β- cell-omics, immunomics, genomics, transcriptomics, proteomics, metabolomics and lipidomics

Migration

Launch public website

Migration

Pubblicazioni

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Autori: Alexia Carré, Sarah J. Richardson, Etienne Larger, Roberto Mallone
Pubblicato in: Diabetologia, Numero 64/1, 2021, Pagina/e 15-25, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05298-y

The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.

Autori: Mallone R, You S.
Pubblicato in: Diabetes, Numero 70(6), 2021, Pagina/e 1247-1249, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi21-0011

Arresting or curing type 1 diabetes: an elusive goal, but closing the gap.

Autori: Martens PJ, Gysemans C, Mathieu C.
Pubblicato in: The Journal of endocrinology, Numero 249(2), 2021, Pagina/e T1-T11, ISSN 0022-0795
Editore: Society for Endocrinology
DOI: 10.1530/joe-20-0552

Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

Autori: Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
Pubblicato in: iScience, 2022, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2021.103653

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.

Autori: Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
Pubblicato in: NAR genomics and bioinformatics, Numero 4(4), 2022, Pagina/e lqac084, ISSN 2631-9268
Editore: [Oxford] : Oxford University Press, [2019]-
DOI: 10.1093/nargab/lqac084

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.

Autori: Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
Pubblicato in: Frontiers in molecular biosciences., Numero 8:689799, 2021, ISSN 2296-889X
Editore: Frontiers Media S.A.,
DOI: 10.3389/fmolb.2021.689799

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes

Autori: Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperbe
Pubblicato in: Diabetologia, Numero 66(7), 2023, Pagina/e 1273-1288, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-023-05912-9

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.

Autori: Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
Pubblicato in: Diabetes., Numero 72(1), 2022, Pagina/e 85-96, ISSN 1939-327X
Editore: [New York, American Diabetes Association]
DOI: 10.2337/db22-0191

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Autori: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Pubblicato in: Nature Reviews Endocrinology, Numero 16/7, 2020, Pagina/e 349-362, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

Autori: Moulder R, Välikangas T, Hirvonen MK, Suomi T, Brorsson CA, Lietzén N, Bruggraber SFA, Overbergh L, Dunger DB, Peakman M, Chmura PJ, Brunak S, Schulte AM, Mathieu C, Knip M, Elo LL, Lahesmaa R; INNODIA consortium
Pubblicato in: Diabetologia, Numero 66(11), 2023, Pagina/e 1983-1996, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-023-05974-9

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Autori: Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Pubblicato in: Cell Reports, Numero 31/1, 2020, Pagina/e 107469, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Autori: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson, Appakalai N. Balamurugan, Carmella Evans-Molina, Decio L. Eizirik, Kieren J. Mather, Silva Arslanian, Raghavendra G
Pubblicato in: Clinical Epigenetics, Numero 12/1, 2020, Pagina/e 116, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-020-00906-5

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Autori: Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew N. Wakeling, Federica Fantuzzi, Kashyap Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas W. Laver, Matthew B. Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Nuri Ozbek, Edip Unal, Ruken Yıldırım, Tusha
Pubblicato in: Journal of Clinical Investigation, Numero 130/12, 2020, Pagina/e 6338-6353, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci141455

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.

Autori: Colli ML, Szymczak F, Eizirik DL.
Pubblicato in: Frontiers in endocrinology., 2020, Pagina/e 11:568446, ISSN 1664-2392
Editore: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.568446

Area Deprivation and Regional Disparities in Treatment and Outcome Quality of 29,284 Pediatric Patients With Type 1 Diabetes in Germany: A Cross-sectional Multicenter DPV Analysis

Autori: Marie Auzanneau, Stefanie Lanzinger, Barbara Bohn, Peter Kroschwald, Ursula Kuhnle-Krahl, Paul Martin Holterhus, Kerstin Placzek, Johannes Hamann, Rainer Bachran, Joachim Rosenbauer, Werner Maier
Pubblicato in: Diabetes Care, Numero 41/12, 2018, Pagina/e 2517-2525, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc18-0724

RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures

Autori: Piron A, Szymczak F, Papadopoulou T, Alvelos MI, Defrance M, Lenaerts T, Eizirik DL, Cnop M
Pubblicato in: Life science alliance, Numero 7(2), 2023, Pagina/e e202302203, ISSN 2575-1077
Editore: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302203

Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.

Autori: Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
Pubblicato in: The Journal of biological chemistry., Numero 298, 2022, Pagina/e 7, ISSN 1083-351X
Editore: Baltimore, MD : American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2022.102096

Preventing type 1 diabetes in childhood.

Autori: Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
Pubblicato in: Science, Numero 373(6554), 2021, Pagina/e 506-510, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abi4742

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Autori: Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
Pubblicato in: Auto- immunity highlights., Numero 12(1), 2021, Pagina/e 6, ISSN 2038-0305
Editore: Springer Verlag Italia
DOI: 10.1186/s13317-021-00148-2

The Role of Beta Cell Recovery in Type 2 Diabetes Remission.

Autori: Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
Pubblicato in: International journal of molecular sciences., Numero 23(13), 2022, Pagina/e 7435, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137435

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Autori: Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
Pubblicato in: Frontiers in immunology., Numero 12:744509, 2021, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.744509

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes

Autori: Bart O Roep
Pubblicato in: Frontiers in immunology, Numero 14, 2023, Pagina/e 14:1112858, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1112858

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Autori: Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
Pubblicato in: Frontiers in immunology, Numero 12:683091, 2021, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.683091

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Autori: Mallone R, Halliez C, Rui J, Herold KC.
Pubblicato in: Diabetes, Numero 71(8), 2022, Pagina/e 1603-1610, ISSN 1939-327X
Editore: [New York, American Diabetes Association]
DOI: 10.2337/dbi21-0036

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.

Autori: Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
Pubblicato in: Cells, Numero 11(15), 2022, Pagina/e 2465, ISSN 2073-4409
Editore: Basel, Switzerland : MDPI
DOI: 10.3390/cells11152465

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Autori: Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group.
Pubblicato in: European journal of immunology., Numero 52(3), 2022, Pagina/e 372–388., ISSN 1521-4141
Editore: Weinheim, Verlag Chemie GmbH.
DOI: 10.1002/eji.202049067

The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes

Autori: Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
Pubblicato in: Diabetologia, Numero 66(6), 2023, Pagina/e 1129–1141, ISSN 1432-0428
Editore: Berlin Springer Verlag
DOI: 10.1007/s00125-023-05888-6

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Autori: Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
Pubblicato in: Frontiers in endocrinology, Numero 13, 2022, Pagina/e 1058345, ISSN 1664-2392
Editore: [Lausanne : Frontiers Research Foundation]
DOI: 10.3389/fendo.2022.1058345

Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism

Autori: Alena Welters, Thomas Meissner, Jürgen Grulich-Henn, Elke Fröhlich-Reiterer, Katharina Warncke, Klaus Mohnike, Oliver Blankenstein, Ulrike Menzel, Nicolin Datz, Esther Bollow, Reinhard W. Holl
Pubblicato in: Orphanet Journal of Rare Diseases, Numero 13/1, 2018, ISSN 1750-1172
Editore: BioMed Central
DOI: 10.1186/s13023-018-0970-8

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Autori: Perez-Hernandez J, Chiurchiu V, Perruche S, You S
Pubblicato in: Frontiers in immunology, Numero 12, 2021, Pagina/e 768133, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.768133

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Autori: Arif S, Domingo-Vila C, Pollock E, Christakou E, Williams E, Tree T.
Pubblicato in: Frontiers in immunology, Numero 14, 2023, Pagina/e 14:1183909, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1183909

Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.

Autori: Carré A, Mallone R.
Pubblicato in: Frontiers in immunology., Numero 12:639682, 2020, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.639682

The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

Autori: Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M.
Pubblicato in: Journal of Clinical Medicine, Numero 11(3), 2022, Pagina/e 663, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11030663

Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes: A matched case‐control study

Autori: Stefanie Lanzinger, Alena Welters, Angelika Thon, Katja Konrad, Thomas Kapellen, Jürgen Grulich‐Henn, Dirk Raddatz, Reinhard W. Holl
Pubblicato in: Pediatric Diabetes, Numero 20/7, 2019, Pagina/e 955-963, ISSN 1399-543X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12894

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.

Autori: Gootjes C, Zwaginga JJ, Roep BO, Nikolic T.
Pubblicato in: Frontiers in immunology., Numero 13, 2022, Pagina/e 886736, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.886736

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Autori: Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Pubblicato in: Islwts, Numero 13(3-4), 2021, Pagina/e 51-65, ISSN 1938-2014
Editore: Landes Bioscience
DOI: 10.1080/19382014.2021.1948282

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.

Autori: Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
Pubblicato in: Frontiers in endocrinology., Numero 13, 2022, Pagina/e 908248, ISSN 1664-2392
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.908248

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Autori: Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
Pubblicato in: Nature biotechnology., Numero 40(7), 2022, Pagina/e 1042–1055, ISSN 1546-1696
Editore: Nature Publishing Company
DOI: 10.1038/s41587-022-01219-z

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.

Autori: Vig S, Lambooij JM, Zaldumbide A, Guigas B.
Pubblicato in: Frontiers in immunology, Numero 12:669492, 2021, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.669492

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Autori: Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
Pubblicato in: Cells, Numero 10(1), 2021, Pagina/e 191, ISSN 2073-4409
Editore: Basel, Switzerland : MDPI
DOI: 10.3390/cells10010191

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

Autori: Tesi M, Bugliani M, Ferri G, Suleiman M, De Luca C, Bosi E, Masini M, De Tata V, Gysemans C, Cardarelli F, Cnop M, Eizirik DL, Marchetti P, Marselli L.
Pubblicato in: Biomolecules, Numero 11(2), 2021, Pagina/e 320, ISSN 2218-273X
Editore: Basel, Switzerland : MDPI
DOI: 10.3390/biom11020320

Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.

Autori: Samassa F, Mallone R.
Pubblicato in: Current opinion in endocrinology, diabetes, and obesity., Numero 29(4), 2022, Pagina/e 370-378, ISSN 1752-2978
Editore: London : Lippincott, Williams & Wilkins, 2007-
DOI: 10.1097/med.0000000000000735

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Autori: Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko
Pubblicato in: Diabetes, Numero 68/7, 2019, Pagina/e 1366-1379, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db19-0119

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Autori: Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
Pubblicato in: Life science alliance, Numero 4(3), 2020, Pagina/e e202000825, ISSN 2575-1077
Editore: Life Science Alliance, LLC,
DOI: 10.26508/lsa.202000825

Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Autori: Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
Pubblicato in: Diabetologia, Numero 64(12), 2021, Pagina/e 2731-2740, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-021-05563-8

Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Autori: Eizirik DL, Szymczak F, Mallone R.
Pubblicato in: Nature reviews. Endocrinology, Numero 19(7), 2023, Pagina/e 425-434, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-023-00826-3

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology

Autori: Diego Balboa, Jonna Saarimäki-Vire, Timo Otonkoski
Pubblicato in: STEM CELLS, Numero 37/1, 2019, Pagina/e 33-41, ISSN 1066-5099
Editore: AlphaMed Press Inc
DOI: 10.1002/stem.2913

Conjugation to a cell-penetrating peptide drives the tumour accumulation of the GLP1R antagonist exendin(9-39)

Autori: Collado Camps E, van Lith SAM, Kip A, Frielink C, Joosten L, Brock R, Gotthardt M.
Pubblicato in: European journal of nuclear medicine and molecular imaging, Numero 50(4), 2022, Pagina/e 996–1004, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-022-06041-y

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

Autori: Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Guido Sebastiani, Francesco Dotta
Pubblicato in: Frontiers in Endocrinology, Numero 11, 2020, ISSN 1664-2392
Editore: Front Endocrinol (Lausanne)
DOI: 10.3389/fendo.2020.596898

Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention

Autori: Carré A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R.
Pubblicato in: Endocrine reviews, Numero 44(4), 2023, Pagina/e 737-751, ISSN 1945-7189
Editore: Endocrine Society
DOI: 10.1210/endrev/bnad007

Epitope-based precision immunotherapy of Type 1 diabetes

Autori: Firdessa Fite R, Bechi Genzano C, Mallone R, Creusot RJ.
Pubblicato in: Human vaccines and immunotherapeutics, Numero 19(1), 2023, Pagina/e 2154098, ISSN 2164-5515
Editore: Landes Bioscience
DOI: 10.1080/21645515.2022.2154098

Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction

Autori: Pugliese LA, De Lorenzi V, Bernardi M, Ghignoli S, Tesi M, Marchetti P, Pesce L, Cardarelli F
Pubblicato in: Scientific reports, Numero 13(1), 2023, Pagina/e 13342, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-40272-9

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

Autori: Bart O Roep, Daniel C S Wheeler, Mark Peakman
Pubblicato in: The Lancet Diabetes & Endocrinology, Numero 7/1, 2019, Pagina/e 65-74, ISSN 2213-8587
Editore: Elsevier BV
DOI: 10.1016/s2213-8587(18)30109-8

Transcription factors that shape the mammalian pancreas

Autori: Rachel E. Jennings, Raphael Scharfmann, Willem Staels
Pubblicato in: Diabetologia, Numero 63/10, 2020, Pagina/e 1974-1980, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05161-0

Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death

Autori: Roca-Rivada A, Marín-Cañas S, Colli ML, Vinci C, Sawatani T, Marselli L, Cnop M, Marchetti P, Eizirik DL
Pubblicato in: Diabetologia, Numero 66(8), 2023, Pagina/e 1544-1556, ISSN 0012-186X
Editore: Springer Verlag
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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

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Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Autori: Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Pubblicato in: Diabetes, Numero 67/11, 2018, Pagina/e 2337-2348, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db18-0295

Immunological biomarkers for the development and progression of type 1 diabetes

Autori: Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Pubblicato in: Diabetologia, Numero 61/11, 2018, Pagina/e 2252-2258, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4726-8

When one becomes many-Alternative splicing in β-cell function and failure

Autori: Maria Inês Alvelos, Jonàs Juan-Mateu, Maikel Luis Colli, Jean-Valéry Turatsinze, Décio L. Eizirik
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 20, 2018, Pagina/e 77-87, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.13388

Biomarkers of islet beta cell stress and death in type 1 diabetes

Autori: Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira
Pubblicato in: Diabetologia, Numero 61/11, 2018, Pagina/e 2259-2265, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4712-1

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Autori: Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Pubblicato in: Molecules, Numero 23/9, 2018, Pagina/e 2100, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23092100

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Autori: Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Pubblicato in: EBioMedicine, Numero 36, 2018, Pagina/e 367-375, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2018.09.040

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Autori: Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Pubblicato in: Diabetes, Numero 67/3, 2018, Pagina/e 423-436, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db17-0736

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Autori: Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik
Pubblicato in: Diabetologia, Numero 61/3, 2018, Pagina/e 636-640, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4536-4

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Autori: Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Pubblicato in: The FASEB Journal, Numero 32/3, 2018, Pagina/e 1524-1536, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700710R

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells

Autori: Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-15417-2

Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

Autori: Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero 103/9, 2018, Pagina/e 3350-3358, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/jc.2018-00500

Europe has to step up its efforts to produce innovative and safe diabetes technology

Autori: Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Pubblicato in: Diabetologia, Numero 60/12, 2017, Pagina/e 2532-2533, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4455-4

MicroRNAs

Autori: Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese
Pubblicato in: Current Opinion in Endocrinology & Diabetes and Obesity, Numero 25/4, 2018, Pagina/e 237-245, ISSN 1752-296X
Editore: Lippincott Williams & Wilkins Ltd.
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Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Autori: Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Fr
Pubblicato in: Science Immunology, Numero 3/20, 2018, Pagina/e eaao4013, ISSN 2470-9468
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aao4013

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Autori: Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia Carré, Sheena Pinto, Slobodan Culina, Noémie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, Søren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, G
Pubblicato in: Cell Metabolism, Numero 28/6, 2018, Pagina/e 946-960.e6, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2018.07.007

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

Autori: Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina
Pubblicato in: Current Diabetes Reports, Numero 18/11, 2018, ISSN 1534-4827
Editore: Current Science Inc.
DOI: 10.1007/s11892-018-1083-4

Virus-like infection induces human β cell dedifferentiation

Autori: Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann
Pubblicato in: JCI Insight, Numero 3/3, 2018, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.97732

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Autori: Piero Marchetti, Mara Suleiman, Lorella Marselli
Pubblicato in: Diabetologia, Numero 61/4, 2018, Pagina/e 770-774, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4546-x

MANF protects human pancreatic beta cells against stress-induced cell death

Autori: Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Päivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutškov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski
Pubblicato in: Diabetologia, Numero 61/10, 2018, Pagina/e 2202-2214, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4687-y

Novel minor HLA DR associated antigens in type 1 diabetes

Autori: Denise Müller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio
Pubblicato in: Clinical Immunology, Numero 194, 2018, Pagina/e 87-91, ISSN 1521-6616
Editore: Academic Press
DOI: 10.1016/j.clim.2018.07.001

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

Autori: Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, Jürgen Enczmann, Thomas Meissner
Pubblicato in: Genes, Numero 8/5, 2017, Pagina/e 146, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes8050146

DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway

Autori: Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis Castaño, Izortze Santin
Pubblicato in: Diabetologia, 2018, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4782-0

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Autori: Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
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Understanding type 1 diabetes through proteomics

Autori: Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
Pubblicato in: Expert Review of Proteomics, Numero 14/7, 2017, Pagina/e 571-580, ISSN 1478-9450
Editore: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1345633

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

Autori: Saurabh Vig, Mijke Buitinga, Dieter Rondas, Inne Crèvecoeur, Marc van Zandvoort, Etienne Waelkens, Decio L. Eizirik, Conny Gysemans, Pieter Baatsen, Chantal Mathieu, Lut Overbergh
Pubblicato in: Cell Death & Disease, Numero 10/4, 2019, Pagina/e 309, ISSN 2041-4889
Editore: Nature Publishing Group
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Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials

Autori: Jessica S. Suwandi, Tatjana Nikolic, Bart O. Roep
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, Pagina/e 1598, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2017.01598

Fostering improved human islet research: a European perspective

Autori: Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Pubblicato in: Diabetologia, Numero 62/8, 2019, Pagina/e 1514-1516, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Autori: Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Pubblicato in: Molecular Metabolism, Numero 24, 2019, Pagina/e 98-107, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

Autori: Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti
Pubblicato in: Molecular and Cellular Endocrinology, Numero 473, 2018, Pagina/e 186-193, ISSN 0303-7207
Editore: Elsevier BV
DOI: 10.1016/j.mce.2018.01.019

Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach

Autori: Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl
Pubblicato in: Diabetes Care, Numero 40/3, 2017, Pagina/e 309-316, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc16-1625

Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort

Autori: Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl
Pubblicato in: Experimental and Clinical Endocrinology & Diabetes, Numero 125/10, 2017, Pagina/e 661-668, ISSN 0947-7349
Editore: Johann Ambrosius Barth
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Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization

Autori: Subhash K. Tripathi, Tommi Välikangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa
Pubblicato in: iScience, Numero 11, 2019, Pagina/e 334-355, ISSN 2589-0042
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Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Autori: Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
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Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

Autori: Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin Béhé, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt
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Editore: Kexue Chubaneshe/Science Press
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Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells

Autori: Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa
Pubblicato in: iScience, Numero 19, 2019, Pagina/e 340-357, ISSN 2589-0042
Editore: Elsevier
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ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor

Autori: Pamela L. Toledo, Juha M. Torkko, Andreas Müller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Pubblicato in: Journal of Biological Chemistry, Numero 294/21, 2019, Pagina/e 8564-8576, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
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Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative

Autori: Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl
Pubblicato in: Pediatric Diabetes, Numero 19/7, 2018, Pagina/e 1271-1275, ISSN 1399-543X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12711

The supply chain of human pancreatic β cell lines

Autori: Raphael Scharfmann, Willem Staels, Olivier Albagli
Pubblicato in: Journal of Clinical Investigation, Numero 129/9, 2019, Pagina/e 3511-3520, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci129484

The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Autori: Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio Eizirik
Pubblicato in: Journal of Molecular Endocrinology, 2019, ISSN 0952-5041
Editore: Society for Endocrinology
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Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration

Autori: Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
Pubblicato in: Pediatric Diabetes, Numero 20/3, 2019, Pagina/e 282-285, ISSN 1399-543X
Editore: Blackwell Publishing Inc.
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MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

Autori: Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Pubblicato in: International Journal of Molecular Sciences, Numero 19/12, 2018, Pagina/e 3705, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg

Autori: Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl
Pubblicato in: Pediatric Diabetes, Numero 19/5, 2018, Pagina/e 937-944, ISSN 1399-543X
Editore: Blackwell Publishing Inc.
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Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

Autori: Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
Pubblicato in: Diabetologia, Numero 62/8, 2019, Pagina/e 1329-1336, ISSN 0012-186X
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Risk factors for decline in renal function among young adults with type 1 diabetes

Autori: Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl
Pubblicato in: Journal of Diabetes and its Complications, Numero 32/10, 2018, Pagina/e 940-946, ISSN 1056-8727
Editore: Elsevier BV
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Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry

Autori: Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl
Pubblicato in: The Journal of Pediatrics, Numero 201, 2018, Pagina/e 78-85.e4, ISSN 0022-3476
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Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue

Autori: Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell
Pubblicato in: International Journal of Mass Spectrometry, Numero 437, 2019, Pagina/e 10-16, ISSN 1387-3806
Editore: Elsevier BV
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Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Autori: Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl
Pubblicato in: Diabetologia, Numero 61/6, 2018, Pagina/e 1354-1361, ISSN 0012-186X
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Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries

Autori: Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-Jørgensen, Elke Froehlich-Reiterer, Maria
Pubblicato in: Diabetes Care, Numero 42/3, 2019, Pagina/e e37-e39, ISSN 0149-5992
Editore: American Diabetes Association
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CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases

Autori: Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi
Pubblicato in: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Editore: Academic Press
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Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Autori: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
Pubblicato in: Cell, Numero 176/4, 2019, Pagina/e 882-896.e18, ISSN 0092-8674
Editore: Cell Press
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The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

Autori: Ernesto S. Nakayasu, Wei-Jun Qian, Carmella Evans-Molina, Raghavendra G. Mirmira, Decio L. Eizirik, Thomas O. Metz
Pubblicato in: Expert Review of Proteomics, Numero 16/7, 2019, Pagina/e 569-582, ISSN 1478-9450
Editore: Future Drugs Ltd.
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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

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Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

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