Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881 | RHAPSODY | Project | Results | H2020 | CORDIS

Rezultaty

Migration

Integrated model of pre-diabetes and T2D populations

Integrated model of prediabetes and T2D populations

Assessment of insulin action and secretion in preclinical models

Migration

Economic model of pre-diabetes populations
Health technology assessment of new biomarker technologies at the early stages of development and dissemination

Health technology assessment of new biomarker technologies at the early stages of development and dissemination.

Project flyer

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Website

Migration

Sustainable platform

Webbased platform online and accessible

Publikacje

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Autorzy: Wu, Chuanyan; Borné, Yan; Gao, Rui; López Rodriguez, Maykel; Roell, William C.; Wilson, Jonathan M.; Regmi, Ajit; Luan, Cheng; Aly, Dina Mansour; Peter, Andreas; Machann, Jürgen; Staiger, Harald; Fritsche, Andreas; Birkenfeld, Andreas L.; Tao, Rongya; Wagner, Robert; Canouil, Mickaël; Hong, Mun-Gwan; Schwenk, Jochen M.; Ahlqvist, Emma; Kaikkonen, Minna U.; Nilsson, Peter; Shore, Angela C.; Kha
Opublikowane w: Nature Communications, Numer 12, 2021, Strona(/y) 6486, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

An investigation of causal relationships between prediabetes and vascular complications

Autorzy: Mutie, Pascal M.; Pomares-Millan, Hugo; Atabaki-Pasdar, Naeimeh; Jordan, Nina; Adams, Rachel; Daly, Nicole L.; Tajes, Juan Fernandes; Giordano, Giuseppe N.; Franks, Paul W.
Opublikowane w: Nature Communications, Numer 11, 2020, Strona(/y) 4592, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-18386-9

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells

Autorzy: Müller, Andreas; Schmidt, Deborah; Xu, C. Shan; Pang, Song; D’Costa, Joyson Verner; Kretschmar, Susanne; Münster, Carla; Kurth, Thomas; Jug, Florian; Weigert, Martin; Hess, Harald F.; Solimena, Michele
Opublikowane w: Journal of Cell Biology, Numer 220, 2021, Strona(/y) 0021-9525, 1540-8140, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.202010039

Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts

Autorzy: Eva Pagano, Stefan R. A. Konings, Daniela Di Cuonzo, Rosalba Rosato, Graziella Bruno, Amber A. Heijden, Joline Beulens, Roderick Slieker, Jose Leal, Talitha L. Feenstra
Opublikowane w: Diabetes, Obesity and Metabolism, 2021, ISSN 1462-8902
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/dom.14311

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Autorzy: Lytrivi, Maria; Castell, Anne-Laure; Poitout, Vincent; Cnop, Miriam
Opublikowane w: Journal of Molecular Biology, Numer 432, 2020, Strona(/y) 1514-1534, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/j.jmb.2019.09.016

Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge

Autorzy: Si, Lei; Willis, Michael S.; Asseburg, Christian; Nilsson, Andreas; Tew, Michelle; Clarke, Philip M.; Lamotte, Mark; Ramos, Mafalda; Shao, Hui; Shi, Lizheng; Zhang, Ping; McEwan, Phil; Ye, Wen; Herman, William H.; Kuo, Shihchen; Isaman, Deanna J.; Schramm, Wendelin; Sailer, Fabian; Brennan, Alan; Pollard, Daniel; Smolen, Harry J.; Leal, José; Gray, Alastair; Patel, Rishi; Feenstra, Talitha; Palme
Opublikowane w: Value in Health, Numer 23, 2020, Strona(/y) 1163-1170, ISSN 1098-3015
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.04.1832

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Autorzy: Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-25423-8

Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

Autorzy: Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-69758-6

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence

Autorzy: Neha Shrestha, Elisa De Franco, Peter Arvan, Miriam Cnop
Opublikowane w: Frontiers in Endocrinology, Numer 12, 2021, ISSN 1664-2392
Wydawca: frontiers
DOI: 10.3389/fendo.2021.650158

Sequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs

Autorzy: Elisabeth Kemter, Andreas Müller, Martin Neukam, Anna Ivanova, Nikolai Klymiuk, Simone Renner, Kaiyuan Yang, Johannes Broichhagen, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Klaus-Peter Knoch, Marc Bickle, Barbara Ludwig, Kai Johnsson, Heiko Lickert, Thomas Kurth, Eckhard Wolf, Michele Solimena
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 118/37, 2021, Strona(/y) e2107665118, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2107665118

Metabolic and functional heterogeneity in pancreatic β cells

Autorzy: Gabriela da Silva Xavier; Guy A. Rutter
Opublikowane w: Journal of Molecular Biology, 2020, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/j.jmb.2019.08.005

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Autorzy: Leonore Wigger, Marko Barovic, Andreas-David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frederic Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio Bonifacio, Cristina Legido-Quigley, Pierre Barbier Saint Hilaire, Philippe Delerive, Andreas Dahl, Christian Klose, Mathias J. Gerl, Kai Simons, Daniela Aust, Jürgen Weitz, Marius Distler, An
Opublikowane w: Nature Metabolism, Numer 3/7, 2021, Strona(/y) 1017-1031, ISSN 2522-5812
Wydawca: Nature
DOI: 10.1038/s42255-021-00420-9

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Autorzy: Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Pe
Opublikowane w: Cell Reports, Numer 33/9, 2020, Strona(/y) 108466, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.108466

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Autorzy: Lytrivi, Maria; Ghaddar, Kassem; Lopes, Miguel; Rosengren, Victoria; Piron, Anthony; Yi, Xiaoyan; Johansson, Henrik; Lehtiö, Janne; Igoillo-Esteve, Mariana; Cunha, Daniel A.; Marselli, Lorella; Marchetti, Piero; Ortsäter, Henrik; Eizirik, Decio L.; Cnop, Miriam
Opublikowane w: BMC Genomics, 2020, ISSN 1471-2164
Wydawca: BioMed Central
DOI: 10.1186/s12864-020-07003-0

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

Autorzy: Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Hervé Le Stunff, Raphael Scharfmann, Karine Clément, Guy A. Rutter, Olivier Taboureau, Christophe Magnan, Romano Regazzi, Fabrizio Andreelli
Opublikowane w: EBioMedicine, Numer 58, 2020, Strona(/y) 102895, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102895

Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes

Autorzy: Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M. Schulte, Michele Solimena
Opublikowane w: Molecular Metabolism, Numer 27, 2019, Strona(/y) S1-S6, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.006

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Autorzy: Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Opublikowane w: Molecular Metabolism, Numer 37, 2020, Strona(/y) 100991, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.100991

Mechanisms of Weight Loss After Obesity Surgery

Autorzy: Elina Akalestou, Alexander D Miras, Guy A Rutter, Carel W le Roux
Opublikowane w: Endocrine Reviews, 2021, ISSN 0163-769X
Wydawca: The Endocrine Society
DOI: 10.1210/endrev/bnab022

Transcription factors that shape the mammalian pancreas

Autorzy: Jennings, Rachel E.; Scharfmann, Raphael; Staels, Willem
Opublikowane w: Diabetologia, Numer 63, 2020, Strona(/y) 1974-1980, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-020-05161-0

Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans

Autorzy: Ana Rodríguez Sánchez-Archidona, Céline Cruciani-Guglielmacci, Clara Roujeau, Leonore Wigger, Justine Lallement, Jessica Denom, Marko Barovic, Nadim Kassis, Florence Mehl, Jurgen Weitz, Marius Distler, Christian Klose, Kai Simons, Mark Ibberson, Michele Solimena, Christophe Magnan, Bernard Thorens
Opublikowane w: Molecular Metabolism, 2021, Strona(/y) 101355, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2021.101355

Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort

Autorzy: Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart, Joline W. J. Beulens
Opublikowane w: Cardiovascular Diabetology, Numer 18/1, 2019, ISSN 1475-2840
Wydawca: BioMed Central
DOI: 10.1186/s12933-019-0975-1

Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data

Autorzy: Jose Leal, Shelby D. Reed, Rishi Patel, Oliver Rivero-Arias, Yanhong Li, Kevin A. Schulman, Robert M. Califf, Rury R. Holman, Alastair M. Gray
Opublikowane w: Diabetes Care, Numer 43/10, 2020, Strona(/y) 2485-2492, ISSN 0149-5992
Wydawca: American Diabetes Association
DOI: 10.2337/dc20-0717

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Autorzy: Bosi, Emanuele; Marselli, Lorella; De Luca, Carmela; Suleiman, Mara; Tesi, Marta; Ibberson, Mark; Eizirik, Decio L.; Cnop, Miriam; Marchetti, Piero
Opublikowane w: NAR genomics and bioinformatics, Numer 2, 2020, Strona(/y) lqaa097, ISSN 2631-9268
Wydawca: Oxford University Press
DOI: 10.1093/nargab/lqaa097

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

Autorzy: Georgiadou, Eleni; Haythorne, Elizabeth; Dickerson, Matthew T.; Lopez-Noriega, Livia; Pullen, Timothy J.; da Silva Xavier, Gabriela; Davis, Samuel P. X.; Martinez-Sanchez, Aida; Semplici, Francesca; Rizzuto, Rosario; McGinty, James A.; French, Paul M.; Cane, Matthew C.; Jacobson, David A.; Leclerc, Isabelle; Rutter, Guy A.
Opublikowane w: Diabetologia, Numer 63, 2020, Strona(/y) 1368-1381, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-020-05148-x

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Autorzy: Zijian Fang; Shiqian Chen; Philip Pickford; Johannes Broichhagen; David J. Hodson; David J. Hodson; Ivan R. Corrêa; Sunil Kumar; Frederik Görlitz; Christopher Dunsby; Paul M. W. French; Guy A. Rutter; Tricia Tan; Stephen R. Bloom; Alejandra Tomas; Ben Jones
Opublikowane w: ACS Pharmacol Transl Sci, Numer 16, 2020, ISSN 2575-9108
Wydawca: ACS Publications
DOI: 10.1021/acsptsci.0c00022

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Autorzy: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Opublikowane w: Nature Reviews Endocrinology, Numer 16/7, 2020, Strona(/y) 349-362, ISSN 1759-5029
Wydawca: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function

Autorzy: Livia López–Noriega, Guy A. Rutter
Opublikowane w: Frontiers in Endocrinology, Numer 11, 2021, ISSN 1664-2392
Wydawca: Frontiers in endocrinology
DOI: 10.3389/fendo.2020.610213

Estimating risk factor progression equations for the UKPDS Outcomes Model 2 (UKPDS 90)

Autorzy: Jose Leal, Maria Alva, Vanessa Gregory, Alison Hayes, Borislava Mihaylova, Alastair M. Gray, Rury R. Holman, Philip Clarke
Opublikowane w: Diabetic Medicine, Numer 38/10, 2021, ISSN 0742-3071
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/dme.14656

Détection cérébrale du glucose et homéostasie du glucose

Autorzy: Bernard Thorens, Gwenaël Labouèbe
Opublikowane w: Médecine des Maladies Métaboliques, Numer 15/5, 2021, Strona(/y) 518-525, ISSN 1957-2557
Wydawca: Elsevier Masson
DOI: 10.1016/j.mmm.2021.05.004

Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Autorzy: Elina Akalestou; Laurent Genser; Laurent Genser; Guy A. Rutter
Opublikowane w: Frontiers in Endocrinology, Numer 12, 2020, ISSN 1664-2392
Wydawca: Frontiers Media
DOI: 10.3389/fendo.2020.00059

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

Autorzy: Marchetti, Piero; Suleiman, Mara; De Luca, Carmela; Baronti, Walter; Bosi, Emanuele; Tesi, Marta; Marselli, Lorella
Opublikowane w: Seminars in Cell & Developmental Biology, Numer 103, 2021, Strona(/y) 83-93, ISSN 1084-9521
Wydawca: Academic Press
DOI: 10.1016/j.semcdb.2020.04.005

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

Autorzy: Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena, Mark Ibberson, Piero Marchetti, Fabian L. Cardenas-Diaz, Paul J. Gadue, Benoit Hastoy, Leonardo Almeida-Souza, Harvey McMahon, Guy A. Rutter
Opublikowane w: Cell Reports, Numer 34/5, 2021, Strona(/y) 108703, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.108703

Computer simulation models of pre-diabetes populations: a systematic review protocol

Autorzy: Jose Leal, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Opublikowane w: BMJ Open, Numer 7/10, 2017, Strona(/y) e014954, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2016-014954

Painting a new picture of personalised medicine for diabetes

Autorzy: Mark I. McCarthy
Opublikowane w: Diabetologia, Numer 60/5, 2017, Strona(/y) 793-799, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-017-4210-x

Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?

Autorzy: Paul W Franks, Alaitz Poveda
Opublikowane w: Diabetologia, Numer 60/5, 2017, Strona(/y) 784-792, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-017-4207-5

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes

Autorzy: Roderick C. Slieker, Amber A. W. A. van der Heijden, Nienke van Leeuwen, Hailiang Mei, Giel Nijpels, Joline W. J. Beulens, Leen M. ’t Hart
Opublikowane w: Diabetologia, Numer 61/1, 2018, Strona(/y) 138-146, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-017-4467-0

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells

Autorzy: Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann
Opublikowane w: Diabetes, Numer 67/3, 2018, Strona(/y) 461-472, ISSN 0012-1797
Wydawca: American Diabetes Association
DOI: 10.2337/db17-0595

Lifestyle precision medicine: the next generation in type 2 diabetes prevention?

Autorzy: Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Opublikowane w: BMC Medicine, Numer 15/1, 2017, ISSN 1741-7015
Wydawca: BioMed Central
DOI: 10.1186/s12916-017-0938-x

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Autorzy: Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Opublikowane w: Molecular Metabolism, Numer 6/9, 2017, Strona(/y) 1024-1039, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.001

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Autorzy: Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Róbert Wagner
Opublikowane w: Frontiers in Endocrinology, Numer 9, 2018, ISSN 1664-2392
Wydawca: Frontiers Media
DOI: 10.3389/fendo.2018.00082

Modeling human pancreatic beta cell dedifferentiation

Autorzy: Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Opublikowane w: Molecular Metabolism, Numer 10, 2018, Strona(/y) 74-86, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.02.002

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Autorzy: Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Opublikowane w: The Lancet Diabetes & Endocrinology, Numer 6/5, 2018, Strona(/y) 361-369, ISSN 2213-8587
Wydawca: Elsevier BV
DOI: 10.1016/s2213-8587(18)30051-2

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Autorzy: Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Opublikowane w: Molecular Metabolism, 2019, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Autorzy: Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Opublikowane w: Nucleic Acids Research, Numer 46/19, 2018, Strona(/y) 10302-10318, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gky839

Local and regional control of calcium dynamics in the pancreatic islet

Autorzy: Guy A. Rutter, David J. Hodson, Pauline Chabosseau, Elizabeth Haythorne, Timothy J. Pullen, Isabelle Leclerc
Opublikowane w: Diabetes, Obesity and Metabolism, Numer 19, 2017, Strona(/y) 30-41, ISSN 1462-8902
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/dom.12990

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans

Autorzy: Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele
Opublikowane w: The Journal of Clinical Endocrinology & Metabolism, Numer 103/12, 2018, Strona(/y) 4373-4383, ISSN 0021-972X
Wydawca: The Endocrine Society
DOI: 10.1210/jc.2018-00791

Decision models of prediabetes populations: A systematic review

Autorzy: Jose Leal, Liam Mc Morrow, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Opublikowane w: Diabetes, Obesity and Metabolism, 2019, ISSN 1462-8902
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/dom.13684

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Autorzy: Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Opublikowane w: Current Opinion in Pharmacology, Numer 43, 2018, Strona(/y) 40-45, ISSN 1471-4892
Wydawca: Elsevier BV
DOI: 10.1016/j.coph.2018.08.002

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure

Autorzy: Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
Opublikowane w: Endocrinology, 2019, ISSN 1945-7170
Wydawca: Endocrine Society
DOI: 10.1210/en.2019-00098

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor

Autorzy: Pamela L. Toledo, Juha M. Torkko, Andreas Mueller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Opublikowane w: Journal of Biological Chemistry, 2019, Strona(/y) 8564-8576, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.007607

NACHO: a Nanostring nCounter data QC package

Autorzy: Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen ’t Hart, Roderick Slieker
Opublikowane w: Bioinformatics, 2019, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btz647

Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo

Autorzy: Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter
Opublikowane w: Nature Metabolism, Numer 1/6, 2019, Strona(/y) 615-629, ISSN 2522-5812
Wydawca: Nature Metabolism
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Klf6 protects β-cells against insulin resistance-induced dedifferentiation

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