Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881 | RHAPSODY | Project | Results | H2020 | CORDIS

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Integrated model of pre-diabetes and T2D populations

Integrated model of prediabetes and T2D populations

Assessment of insulin action and secretion in preclinical models

Migration

Economic model of pre-diabetes populations
Health technology assessment of new biomarker technologies at the early stages of development and dissemination

Health technology assessment of new biomarker technologies at the early stages of development and dissemination.

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Sustainable platform

Webbased platform online and accessible

Publications

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Auteurs: Wu, Chuanyan; Borné, Yan; Gao, Rui; López Rodriguez, Maykel; Roell, William C.; Wilson, Jonathan M.; Regmi, Ajit; Luan, Cheng; Aly, Dina Mansour; Peter, Andreas; Machann, Jürgen; Staiger, Harald; Fritsche, Andreas; Birkenfeld, Andreas L.; Tao, Rongya; Wagner, Robert; Canouil, Mickaël; Hong, Mun-Gwan; Schwenk, Jochen M.; Ahlqvist, Emma; Kaikkonen, Minna U.; Nilsson, Peter; Shore, Angela C.; Kha
Publié dans: Nature Communications, Numéro 12, 2021, Page(s) 6486, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

An investigation of causal relationships between prediabetes and vascular complications

Auteurs: Mutie, Pascal M.; Pomares-Millan, Hugo; Atabaki-Pasdar, Naeimeh; Jordan, Nina; Adams, Rachel; Daly, Nicole L.; Tajes, Juan Fernandes; Giordano, Giuseppe N.; Franks, Paul W.
Publié dans: Nature Communications, Numéro 11, 2020, Page(s) 4592, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-18386-9

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells

Auteurs: Müller, Andreas; Schmidt, Deborah; Xu, C. Shan; Pang, Song; D’Costa, Joyson Verner; Kretschmar, Susanne; Münster, Carla; Kurth, Thomas; Jug, Florian; Weigert, Martin; Hess, Harald F.; Solimena, Michele
Publié dans: Journal of Cell Biology, Numéro 220, 2021, Page(s) 0021-9525, 1540-8140, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.202010039

Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts

Auteurs: Eva Pagano, Stefan R. A. Konings, Daniela Di Cuonzo, Rosalba Rosato, Graziella Bruno, Amber A. Heijden, Joline Beulens, Roderick Slieker, Jose Leal, Talitha L. Feenstra
Publié dans: Diabetes, Obesity and Metabolism, 2021, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.14311

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Auteurs: Lytrivi, Maria; Castell, Anne-Laure; Poitout, Vincent; Cnop, Miriam
Publié dans: Journal of Molecular Biology, Numéro 432, 2020, Page(s) 1514-1534, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2019.09.016

Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge

Auteurs: Si, Lei; Willis, Michael S.; Asseburg, Christian; Nilsson, Andreas; Tew, Michelle; Clarke, Philip M.; Lamotte, Mark; Ramos, Mafalda; Shao, Hui; Shi, Lizheng; Zhang, Ping; McEwan, Phil; Ye, Wen; Herman, William H.; Kuo, Shihchen; Isaman, Deanna J.; Schramm, Wendelin; Sailer, Fabian; Brennan, Alan; Pollard, Daniel; Smolen, Harry J.; Leal, José; Gray, Alastair; Patel, Rishi; Feenstra, Talitha; Palme
Publié dans: Value in Health, Numéro 23, 2020, Page(s) 1163-1170, ISSN 1098-3015
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.04.1832

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Auteurs: Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-25423-8

Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

Auteurs: Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-69758-6

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence

Auteurs: Neha Shrestha, Elisa De Franco, Peter Arvan, Miriam Cnop
Publié dans: Frontiers in Endocrinology, Numéro 12, 2021, ISSN 1664-2392
Éditeur: frontiers
DOI: 10.3389/fendo.2021.650158

Sequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs

Auteurs: Elisabeth Kemter, Andreas Müller, Martin Neukam, Anna Ivanova, Nikolai Klymiuk, Simone Renner, Kaiyuan Yang, Johannes Broichhagen, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Klaus-Peter Knoch, Marc Bickle, Barbara Ludwig, Kai Johnsson, Heiko Lickert, Thomas Kurth, Eckhard Wolf, Michele Solimena
Publié dans: Proceedings of the National Academy of Sciences, Numéro 118/37, 2021, Page(s) e2107665118, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2107665118

Metabolic and functional heterogeneity in pancreatic β cells

Auteurs: Gabriela da Silva Xavier; Guy A. Rutter
Publié dans: Journal of Molecular Biology, 2020, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2019.08.005

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Auteurs: Leonore Wigger, Marko Barovic, Andreas-David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frederic Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio Bonifacio, Cristina Legido-Quigley, Pierre Barbier Saint Hilaire, Philippe Delerive, Andreas Dahl, Christian Klose, Mathias J. Gerl, Kai Simons, Daniela Aust, Jürgen Weitz, Marius Distler, An
Publié dans: Nature Metabolism, Numéro 3/7, 2021, Page(s) 1017-1031, ISSN 2522-5812
Éditeur: Nature
DOI: 10.1038/s42255-021-00420-9

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Auteurs: Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Pe
Publié dans: Cell Reports, Numéro 33/9, 2020, Page(s) 108466, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.108466

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Auteurs: Lytrivi, Maria; Ghaddar, Kassem; Lopes, Miguel; Rosengren, Victoria; Piron, Anthony; Yi, Xiaoyan; Johansson, Henrik; Lehtiö, Janne; Igoillo-Esteve, Mariana; Cunha, Daniel A.; Marselli, Lorella; Marchetti, Piero; Ortsäter, Henrik; Eizirik, Decio L.; Cnop, Miriam
Publié dans: BMC Genomics, 2020, ISSN 1471-2164
Éditeur: BioMed Central
DOI: 10.1186/s12864-020-07003-0

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

Auteurs: Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Hervé Le Stunff, Raphael Scharfmann, Karine Clément, Guy A. Rutter, Olivier Taboureau, Christophe Magnan, Romano Regazzi, Fabrizio Andreelli
Publié dans: EBioMedicine, Numéro 58, 2020, Page(s) 102895, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102895

Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes

Auteurs: Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M. Schulte, Michele Solimena
Publié dans: Molecular Metabolism, Numéro 27, 2019, Page(s) S1-S6, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.006

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Auteurs: Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Publié dans: Molecular Metabolism, Numéro 37, 2020, Page(s) 100991, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.100991

Mechanisms of Weight Loss After Obesity Surgery

Auteurs: Elina Akalestou, Alexander D Miras, Guy A Rutter, Carel W le Roux
Publié dans: Endocrine Reviews, 2021, ISSN 0163-769X
Éditeur: The Endocrine Society
DOI: 10.1210/endrev/bnab022

Transcription factors that shape the mammalian pancreas

Auteurs: Jennings, Rachel E.; Scharfmann, Raphael; Staels, Willem
Publié dans: Diabetologia, Numéro 63, 2020, Page(s) 1974-1980, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05161-0

Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans

Auteurs: Ana Rodríguez Sánchez-Archidona, Céline Cruciani-Guglielmacci, Clara Roujeau, Leonore Wigger, Justine Lallement, Jessica Denom, Marko Barovic, Nadim Kassis, Florence Mehl, Jurgen Weitz, Marius Distler, Christian Klose, Kai Simons, Mark Ibberson, Michele Solimena, Christophe Magnan, Bernard Thorens
Publié dans: Molecular Metabolism, 2021, Page(s) 101355, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2021.101355

Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort

Auteurs: Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart, Joline W. J. Beulens
Publié dans: Cardiovascular Diabetology, Numéro 18/1, 2019, ISSN 1475-2840
Éditeur: BioMed Central
DOI: 10.1186/s12933-019-0975-1

Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data

Auteurs: Jose Leal, Shelby D. Reed, Rishi Patel, Oliver Rivero-Arias, Yanhong Li, Kevin A. Schulman, Robert M. Califf, Rury R. Holman, Alastair M. Gray
Publié dans: Diabetes Care, Numéro 43/10, 2020, Page(s) 2485-2492, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc20-0717

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Auteurs: Bosi, Emanuele; Marselli, Lorella; De Luca, Carmela; Suleiman, Mara; Tesi, Marta; Ibberson, Mark; Eizirik, Decio L.; Cnop, Miriam; Marchetti, Piero
Publié dans: NAR genomics and bioinformatics, Numéro 2, 2020, Page(s) lqaa097, ISSN 2631-9268
Éditeur: Oxford University Press
DOI: 10.1093/nargab/lqaa097

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

Auteurs: Georgiadou, Eleni; Haythorne, Elizabeth; Dickerson, Matthew T.; Lopez-Noriega, Livia; Pullen, Timothy J.; da Silva Xavier, Gabriela; Davis, Samuel P. X.; Martinez-Sanchez, Aida; Semplici, Francesca; Rizzuto, Rosario; McGinty, James A.; French, Paul M.; Cane, Matthew C.; Jacobson, David A.; Leclerc, Isabelle; Rutter, Guy A.
Publié dans: Diabetologia, Numéro 63, 2020, Page(s) 1368-1381, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05148-x

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Auteurs: Zijian Fang; Shiqian Chen; Philip Pickford; Johannes Broichhagen; David J. Hodson; David J. Hodson; Ivan R. Corrêa; Sunil Kumar; Frederik Görlitz; Christopher Dunsby; Paul M. W. French; Guy A. Rutter; Tricia Tan; Stephen R. Bloom; Alejandra Tomas; Ben Jones
Publié dans: ACS Pharmacol Transl Sci, Numéro 16, 2020, ISSN 2575-9108
Éditeur: ACS Publications
DOI: 10.1021/acsptsci.0c00022

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Auteurs: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Publié dans: Nature Reviews Endocrinology, Numéro 16/7, 2020, Page(s) 349-362, ISSN 1759-5029
Éditeur: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function

Auteurs: Livia López–Noriega, Guy A. Rutter
Publié dans: Frontiers in Endocrinology, Numéro 11, 2021, ISSN 1664-2392
Éditeur: Frontiers in endocrinology
DOI: 10.3389/fendo.2020.610213

Estimating risk factor progression equations for the UKPDS Outcomes Model 2 (UKPDS 90)

Auteurs: Jose Leal, Maria Alva, Vanessa Gregory, Alison Hayes, Borislava Mihaylova, Alastair M. Gray, Rury R. Holman, Philip Clarke
Publié dans: Diabetic Medicine, Numéro 38/10, 2021, ISSN 0742-3071
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dme.14656

Détection cérébrale du glucose et homéostasie du glucose

Auteurs: Bernard Thorens, Gwenaël Labouèbe
Publié dans: Médecine des Maladies Métaboliques, Numéro 15/5, 2021, Page(s) 518-525, ISSN 1957-2557
Éditeur: Elsevier Masson
DOI: 10.1016/j.mmm.2021.05.004

Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Auteurs: Elina Akalestou; Laurent Genser; Laurent Genser; Guy A. Rutter
Publié dans: Frontiers in Endocrinology, Numéro 12, 2020, ISSN 1664-2392
Éditeur: Frontiers Media
DOI: 10.3389/fendo.2020.00059

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

Auteurs: Marchetti, Piero; Suleiman, Mara; De Luca, Carmela; Baronti, Walter; Bosi, Emanuele; Tesi, Marta; Marselli, Lorella
Publié dans: Seminars in Cell & Developmental Biology, Numéro 103, 2021, Page(s) 83-93, ISSN 1084-9521
Éditeur: Academic Press
DOI: 10.1016/j.semcdb.2020.04.005

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

Auteurs: Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena, Mark Ibberson, Piero Marchetti, Fabian L. Cardenas-Diaz, Paul J. Gadue, Benoit Hastoy, Leonardo Almeida-Souza, Harvey McMahon, Guy A. Rutter
Publié dans: Cell Reports, Numéro 34/5, 2021, Page(s) 108703, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.108703

Computer simulation models of pre-diabetes populations: a systematic review protocol

Auteurs: Jose Leal, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Publié dans: BMJ Open, Numéro 7/10, 2017, Page(s) e014954, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2016-014954

Painting a new picture of personalised medicine for diabetes

Auteurs: Mark I. McCarthy
Publié dans: Diabetologia, Numéro 60/5, 2017, Page(s) 793-799, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-017-4210-x

Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?

Auteurs: Paul W Franks, Alaitz Poveda
Publié dans: Diabetologia, Numéro 60/5, 2017, Page(s) 784-792, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-017-4207-5

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes

Auteurs: Roderick C. Slieker, Amber A. W. A. van der Heijden, Nienke van Leeuwen, Hailiang Mei, Giel Nijpels, Joline W. J. Beulens, Leen M. ’t Hart
Publié dans: Diabetologia, Numéro 61/1, 2018, Page(s) 138-146, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-017-4467-0

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells

Auteurs: Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann
Publié dans: Diabetes, Numéro 67/3, 2018, Page(s) 461-472, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db17-0595

Lifestyle precision medicine: the next generation in type 2 diabetes prevention?

Auteurs: Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Publié dans: BMC Medicine, Numéro 15/1, 2017, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-017-0938-x

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Auteurs: Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Publié dans: Molecular Metabolism, Numéro 6/9, 2017, Page(s) 1024-1039, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.001

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Auteurs: Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Róbert Wagner
Publié dans: Frontiers in Endocrinology, Numéro 9, 2018, ISSN 1664-2392
Éditeur: Frontiers Media
DOI: 10.3389/fendo.2018.00082

Modeling human pancreatic beta cell dedifferentiation

Auteurs: Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Publié dans: Molecular Metabolism, Numéro 10, 2018, Page(s) 74-86, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.02.002

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Auteurs: Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Publié dans: The Lancet Diabetes & Endocrinology, Numéro 6/5, 2018, Page(s) 361-369, ISSN 2213-8587
Éditeur: Elsevier BV
DOI: 10.1016/s2213-8587(18)30051-2

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Auteurs: Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Publié dans: Molecular Metabolism, 2019, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Auteurs: Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Publié dans: Nucleic Acids Research, Numéro 46/19, 2018, Page(s) 10302-10318, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gky839

Local and regional control of calcium dynamics in the pancreatic islet

Auteurs: Guy A. Rutter, David J. Hodson, Pauline Chabosseau, Elizabeth Haythorne, Timothy J. Pullen, Isabelle Leclerc
Publié dans: Diabetes, Obesity and Metabolism, Numéro 19, 2017, Page(s) 30-41, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.12990

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans

Auteurs: Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 103/12, 2018, Page(s) 4373-4383, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/jc.2018-00791

Decision models of prediabetes populations: A systematic review

Auteurs: Jose Leal, Liam Mc Morrow, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Publié dans: Diabetes, Obesity and Metabolism, 2019, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.13684

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Auteurs: Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Publié dans: Current Opinion in Pharmacology, Numéro 43, 2018, Page(s) 40-45, ISSN 1471-4892
Éditeur: Elsevier BV
DOI: 10.1016/j.coph.2018.08.002

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure

Auteurs: Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
Publié dans: Endocrinology, 2019, ISSN 1945-7170
Éditeur: Endocrine Society
DOI: 10.1210/en.2019-00098

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor

Auteurs: Pamela L. Toledo, Juha M. Torkko, Andreas Mueller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Publié dans: Journal of Biological Chemistry, 2019, Page(s) 8564-8576, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.007607

NACHO: a Nanostring nCounter data QC package

Auteurs: Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen ’t Hart, Roderick Slieker
Publié dans: Bioinformatics, 2019, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btz647

Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo

Auteurs: Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter
Publié dans: Nature Metabolism, Numéro 1/6, 2019, Page(s) 615-629, ISSN 2522-5812
Éditeur: Nature Metabolism
DOI: 10.1038/s42255-019-0075-2

Klf6 protects β-cells against insulin resistance-induced dedifferentiation

Auteurs: Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Publié dans: Molecular Metabolism, Numéro 35, 2020, Page(s) 100958, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.02.001

The supply chain of human pancreatic β cell lines

Auteurs: Raphael Scharfmann, Willem Staels, Olivier Albagli
Publié dans: Journal of Clinical Investigation, Numéro 129/9, 2019, Page(s) 3511-3520, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci129484

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas

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Publié dans: Dalton Transactions, Numéro 49/15, 2020, Page(s) 4732-4740, ISSN 1477-9226
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0dt00332h

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Auteurs: Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Publié dans: Diabetologia, Numéro 63/2, 2020, Page(s) 395-409, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

Fostering improved human islet research: a European perspective

Auteurs: Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Publié dans: Diabetologia, Numéro 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine

Auteurs: Bernard Thorens, Ana Rodriguez, Céline Cruciani-Guglielmacci, Leonore Wigger, Mark Ibberson, Christophe Magnan
Publié dans: Molecular Metabolism, Numéro 27, 2019, Page(s) S147-S154, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.008

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

Auteurs: Blandine Gausserès, Junjun Liu, Ewout Foppen, Cécile Tourrel-Cuzin, Ana Rodriguez Sanchez-Archidona, Etienne Delangre, Céline Cruciani-Guglielmacci, Stéphanie Pons, Uwe Maskos, Bernard Thorens, Christophe Magnan, Jamileh Movassat, Kamel Maouche
Publié dans: Biomolecules, Numéro 10/7, 2020, Page(s) 1057, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom10071057

Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis

Auteurs: So, WY; Liu, WN; Teo, AKK; Rutter, GA; Han, W
Publié dans: Science Translational Medicine, 2021, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abb1038

The making of insulin in health and disease

Auteurs: Vasiljević, Jovana; Torkko, Juha M.; Knoch, Klaus-Peter; Solimena, Michele
Publié dans: Diabetologia, Numéro 63, 2020, Page(s) 1981-1989, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05192-7

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells

Auteurs: C. Berthault, W. Staels, R. Scharfmann
Publié dans: Molecular Metabolism, Numéro 42, 2020, Page(s) 101060, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101060

Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion

Auteurs: Albatoul Zakaria, Claire Berthault, Bertrand Cosson, Vincent Jung, Ida Chiara Guerrera, Latif Rachdi, Raphael Scharfmann
Publié dans: Journal of Biological Chemistry, Numéro 297/1, 2021, Page(s) 100839, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100839

Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study

Auteurs: Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N. Giordano, Mikael Åkerlund, Mathias J. Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K. Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J. Pullen, Tommi Suvitaival, Asger Wretlind, Pe
Publié dans: Diabetes, 2021, Page(s) db201281, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db20-1281

Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells

Auteurs: Eleni Georgiadou, Guy A. Rutter
Publié dans: Cell Calcium, Numéro 91, 2020, Page(s) 102282, ISSN 0143-4160
Éditeur: Churchill Livingstone
DOI: 10.1016/j.ceca.2020.102282

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

Auteurs: Slieker, Roderick C.; Donnelly, Louise A.; Fitipaldi, Hugo; Bouland, Gerard A.; Giordano, Giuseppe N.; Åkerlund, Mikael; Gerl, Mathias J.; Ahlqvist, Emma; Ali, Ashfaq; Dragan, Iulian; Festa, Andreas; Hansen, Michael K.; Mansour Aly, Dina; Kim, Min; Kuznetsov, Dmitry; Mehl, Florence; Klose, Christian; Simons, Kai; Pavo, Imre; Pullen, Timothy J.; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter;
Publié dans: Diabetologia, Numéro 64, 2021, Page(s) 1982–1989, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-021-05490-8

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice

Auteurs: Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Isabelle Leclerc, Guy A. Rutter, Gabriela da Silva Xavier
Publié dans: Diabetologia, Numéro 64/1, 2021, Page(s) 129-141, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05292-4

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research

Auteurs: Ming Hu, Ines Cherkaoui, Shivani Misra, Guy A. Rutter
Publié dans: Frontiers in Endocrinology, Numéro 11, 2020, Page(s) 576-632, ISSN 1664-2392
Éditeur: Frontiers in Endocrinology
DOI: 10.3389/fendo.2020.576632

Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration

Auteurs: Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan, Nathalie Janel
Publié dans: Frontiers in Neurology, Numéro 10, 2019, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.00807

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Auteurs: Cohrs, Christian M.; Panzer, Julia K.; Drotar, Denise M.; Enos, Stephen J.; Kipke, Nicole; Chen, Chunguang; Bozsak, Robert; Schöniger, Eyke; Ehehalt, Florian; Distler, Marius; Brennand, Ana; Bornstein, Stefan R.; Weitz, Jürgen; Solimena, Michele; Speier, Stephan
Publié dans: Cell Reports, Numéro 31, 2020, Page(s) 107469, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing

Auteurs: Seyed M. Ghiasi, Guy A. Rutter
Publié dans: Frontiers in Endocrinology, Numéro 12, 2021, ISSN 1664-2392
Éditeur: Frontiers
DOI: 10.3389/fendo.2021.625235

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits

Auteurs: Bouland, Gerard A; Beulens, Joline WJ; Nap, Joey; van der Slik, Arno R; Zaldumbide, Arnaud; Hart, Leen M’t; Slieker, Roderick C
Publié dans: NAR Genomics and Bioinformatics, Numéro 2, 2020, ISSN 2631-9268
Éditeur: Oxford University Press
DOI: 10.1093/nargab/lqaa085

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

Auteurs: S. Neda Mousavy Gharavy, Bryn M. Owen, Steven J. Millership, Pauline Chabosseau, Grazia Pizza, Aida Martinez-Sanchez, Emirhan Tasoez, Eleni Georgiadou, Ming Hu, Nicholas H. F. Fine, David A. Jacobson, Matthew T. Dickerson, Olof Idevall-Hagren, Alex Montoya, Holger Kramer, Zenobia Mehta, Dominic J. Withers, Nikolay Ninov, Paul J. Gadue, Fabian L. Cardenas-Diaz, Céline Cruciani-Guglielmacci, Christ
Publié dans: Diabetologia, Numéro 64/4, 2021, Page(s) 850-864, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05350-x

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Auteurs: Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J.Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien
Publié dans: Molecular Metabolism, Numéro 40, 2020, Page(s) 101015, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101015

Covid-19 and Diabetes: A Complex Bidirectional Relationship

Auteurs: Muniangi-Muhitu, Hermine; Akalestou, Elina; Salem, Victoria; Misra, Shivani; Oliver, Nicholas S.; Rutter, Guy A.
Publié dans: Frontiers in Endocrinology, Numéro 11, 2020, Page(s) 582936, ISSN 1664-2392
Éditeur: Frontiers Media SA
DOI: 10.3389/fendo.2020.582936

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