Biomarker Enterprise to Attack DKD - Sofia ref.: 115974

Informations projet

BEAt-DKD

N° de convention de subvention: 115974

DOI 10.3030/115974

Projet clôturé

Date de signature de la CE 20 Decembre 2016

Date de début 1 Septembre 2016

Date de fin 31 Août 2023

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total € 30 586 654,14

Contribution de l’UE € 15 085 937,00

Coordonné par

LUNDS UNIVERSITET
Sweden

Livrables

Documents, reports (1)

White paper on strengths and weaknesses of using biomarker panels (or multiple biomarker scores) as risk stratifiers, as targets in drug development and as surrogate endpoints for regulatory approval

Migration

Publications

Peer reviewed articles (164)

Predictive Biomarkers in Nephrology Around the Corner

Auteurs: Paul Perco, Kumar Sharma
Publié dans: Kidney International Reports, Numéro 5/1, 2020, Page(s) 1-3, ISSN 2468-0249
Éditeur: Elsevier
DOI: 10.1016/j.ekir.2019.10.009

Effects of albuminuria-lowering treatments on inflammation markers: A post hoc analysis from the ROTATE trials

Auteurs: Taha Sen, Viktor Rotbain Curovic, Niels Jongs, Gozewijn D Laverman, Adriaan Kooy, Frederik Persson, Peter Rossing, Hiddo J L Heerspink
Publié dans: Diabetes, Obesity and Metababolism, Numéro Aug;25(8), 2023, Page(s) 2413-2418, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.15109

Development and Validation of a Prediction Model for Future Estimated Glomerular Filtration Rate in People With Type 2 Diabetes and Chronic Kidney Disease

Auteurs: Mariella Gregorich, Michael Kammer, Andreas Heinzel, Carsten Böger, Kai-Uwe Eckardt, Hiddo Lambers Heerspink, Bettina Jung, Gert Mayer, Heike Meiselbach, Matthias Schmid,Ulla T. Schultheiss, Georg Heinze, Rainer Oberbauer, for the BEAt-DKD Consortium
Publié dans: JAMA Network Open, Numéro 6(4), 2023, Page(s) e231870, ISSN 0098-7484
Éditeur: American Medical Association
DOI: 10.1001/jamanetworkopen.2023.1870

Surprising Hyperkalemia of 10.2 mmol/L in a Patient with Hyperglycemia: A Case Report

Auteurs: Czogalla J, Tariparast P.A, Huber T.B, Janneck M, Grahammer F
Publié dans: Case Reports in Nephrology and Dialysis, Numéro 11/1, 2021, Page(s) 69–77, ISSN 2296-9705
Éditeur: S. Karger AG.
DOI: 10.1159/000512590

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

Auteurs: Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Publié dans: Genome Medicine, Numéro Vol. 106, No. 2, 2023, Page(s) 388–396, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-022-01145-4

Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis

Auteurs: Sara Denicolò, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Publié dans: Biomolecules, Numéro 13(1), 89, 2023, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom13010089

Contribution of Real-World Evidence in European Medicines Agency's Regulatory Decision Making

Auteurs: Elisabeth Bakker, Kelly Plueschke, Carla J Jonker, Xavier Kurz, Viktoriia Starokozhko, Peter G M Mol 
Publié dans: Clinical Pharmacology Therapeutics, Numéro Jan;113(1), 2023, Page(s) 135-151, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.2766

Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease—prospective data from the German Chronic Kidney Disease cohort

Auteurs: Johannes Ruhe, Jennifer Nadal, Barbara Bärthlein, Heike Meiselbach, Ulla T Schultheiss, Fruzsina Kotsis, Helena Stockmann, Vera Krane, Claudia Sommerer, Ivonne Löffler, Turgay Saritas, Jan T Kielstein, Thomas Sitter, Markus P Schneider, Matthias Schmid, Christoph Wanner, Kai-Uwe Eckardt, Gunter Wolf, Martin Busch
Publié dans: Clin Kidney J, Numéro 16(11), 2023, Page(s) 2032-2040, ISSN 2048-8505
Éditeur: Oxford University Press
DOI: 10.1093/ckj/sfad194

Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy

Auteurs: Fabian Braun, Ahmed Abed, Dominik Sellung, Manuel Rogg, Mathias Woidy, Oysten Eikrem, Nicola Wanner, Jessica Gambardella, Sandra D Laufer, Fabian Haas, Milagros N Wong, Bernhard Dumoulin, Paula Rischke, Anne Mühlig, Wiebke Sachs, Katharina von Cossel, Kristina Schulz, Nicole Muschol, Sören W Gersting, Ania C Muntau, Oliver Kretz, Oliver Hahn, Markus M Rinschen, Michael Mauer, Tillmann Bork, Flor
Publié dans: Journal of Clinical Investigation, Numéro Jun 1;133(11), 2023, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci157782

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

Auteurs: Danielle Vaughan, Olli Ritvos, Robert Mitchell, Oliver Kretz, Maciej Lalowski, Helge Amthor, David Chambers, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Randy Ballesteros, Tobias B. Huber, Bernd Denecke, Darius Widera, Abir Mukherjee, Ketan Patel
Publié dans: European Journal of Translational Myology, Numéro 30/1, 2020, Page(s) 62-78, ISSN 2037-7460
Éditeur: PAGEPress Publications
DOI: 10.4081/ejtm.2019.8737

Differential prognostic utility of adiposity measures in chronic kidney disease

Auteurs: Vladimir Cejka, Jennifer Nadal, Matthias Schmid, Claudia Sommerer, Thomas Sitter, Heike Meiselbach. Martin Busch, Markus P Schneider, Turgay Saritas, Ulla T Schultheiss, Fruzsina Kotsis, Christoph Wanner, Kai-Uwe Eckardt, Vera Krane, GCKD Investigators.
Publié dans: J Renal Nutr, Numéro 33(4), 2023, Page(s) 546-554, ISSN 1532-8503
Éditeur: Saunders
DOI: 10.1053/j.jrn.2023.04.006

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis

Auteurs: Eva M Buhl, Sonja Djudjaj, Barbara M Klinkhammer, Katja Ermert, Victor G Puelles, Maja T Lindenmeyer, Clemens D Cohen, Chaoyong He, Erawan Borkham‐Kamphorst, Ralf Weiskirchen, Bernd Denecke, Panuwat Trairatphisan, Julio Saez‐Rodriguez, Tobias B Huber, Lorin E Olson, Jürgen Floege, Peter Boor
Publié dans: EMBO Molecular Medicine, Numéro 12/3, 2020, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911021

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Auteurs: Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Gardar Sveinbjornsson, Thomas W Winkler, Felix Günther, Klaus J Stark, Jin-Fang Chai, Bamidele O Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle
Publié dans: Kidney international, Numéro 102(3), 2022, Page(s) 624-39, ISSN 0085-2538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2022.05.021

Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease

Auteurs: Raina D. Ramnath, Matthew J. Butler, Georgina Newman, Sara Desideri, Amy Russell, Abigail C. Lay, Chris R. Neal, Yan Qiu, Sarah Fawaz, Karen L. Onions, Monica Gamez, Michael Crompton, Chris Michie, Natalie Finch, Richard J. Coward, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell
Publié dans: Kidney International, Numéro 97/5, 2020, Page(s) 951-965, ISSN 0085-2538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2019.09.035

Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI

Auteurs: Anneloes de Boer MD,Giulia Villa MS,Octavia Bane PhD,Michael Bock PhD,Eleanor F. Cox PhD,Ilona A. Dekkers MD, PhD,Per Eckerbom MD,Maria A. Fernández-Seara PhD,Susan T. Francis PhD,Bryan Haddock PhD,Michael E. Hall MD,Pauline Hall Barrientos PhD,Ingo Hermann MS,Paul D. Hockings PhD,Hildo J. Lamb MD, PhD,Christoffer Laustsen PhD,Ruth P. Lim MD,David M. Morris PhD,Steffen Ringgaard PhD,Suraj D. Sera
Publié dans: Journal of Magnetic Resonance Imaging, 2020, ISSN 1053-1807
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/jmri.27419

Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

Auteurs: Iosif Mendichovszky, Pim Pullens, Ilona Dekkers, Fabio Nery, Octavia Bane, Andreas Pohlmann, Anneloes de Boer, Alexandra Ljimani, Aghogho Odudu, Charlotte Buchanan, Kanishka Sharma, Christoffer Laustsen, Anita Harteveld, Xavier Golay, Ivan Pedrosa, David Alsop, Sean Fain, Anna Caroli, Pottumarthi Prasad, Susan Francis, Eric Sigmund, Maria Fernández‐Seara, Steven Sourbron
Publié dans: Magnetic Resonance Materials in Physics, Biology and Medicine, Numéro 33/1, 2020, Page(s) 131-140, ISSN 0968-5243
Éditeur: Springer Verlag
DOI: 10.1007/s10334-019-00784-w

Interleukin-6 and Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes: New Insights From CANVAS

Auteurs: Akihiko Koshino, Meir Schechter, Taha Sen , Priya Vart, Brendon L Neuen, Bruce Neal, Clare Arnott , Vlado Perkovic, Paul M Ridker, Katherine R Tuttle, Michael K Hansen, Hiddo J L Heerspink
Publié dans: Diabetes Care, Numéro Nov 1;45(11), 2022, Page(s) 2644-2652, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc22-0866

Machine‐learning–based early prediction of end‐stage renal disease in patients with diabetic kidney disease using clinical trials data

Auteurs: Sunil Belur Nagaraj, Michelle J. Pena, Wenjun Ju, Hiddo L. Heerspink
Publié dans: Diabetes, Obesity and Metabolism, Numéro 22/12, 2020, Page(s) 2479-2486, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.14178

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities

Auteurs: Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
Publié dans: Disease Models & Mechanisms, Numéro 14/2, 2020, ISSN 1754-8403
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dmm.047555

Effect of empagliflozin on kidney biochemical and imaging outcomes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF)

Auteurs: Matthew M.Y. Lee, Keith A. Gillis, Katriona J.M. Brooksbank, Sarah Allwood-Spiers, Pauline Hall Barrientos, Kirsty Wetherall, Giles Roditi, Bashair AlHummiany, Colin Berry, Ross T. Campbell, Victor Chong, Liz Coyle, Kieran F. Docherty, John G. Dreisbach, Bernd Kuehn, Catherine Labinjoh, Ninian N. Lang, Vera Lennie, Kenneth Mangion, Alex McConnachie, Clare L. Murphy, Colin J. Petrie, John R. Petrie
Publié dans: Circulation, Numéro 146, 2022, Page(s) 364–367, ISSN 0009-7322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.059851

Validation of a Novel Predictive Algorithm for Kidney Failure in Patients Suffering from Chronic Kidney Disease: The Prognostic Reasoning System for Chronic Kidney Disease (PROGRES-CKD)

Auteurs: Francesco Bellocchio; Caterina Lonati; Jasmine Ion Titapiccolo; Jennifer Nadal; Heike Meiselbach; Matthias Schmid; Barbara Baerthlein; Ulrich Tschulena; Markus P. Schneider; Ulla T. Schultheiss; Carlo Barbieri; Christoph Moore; Sonja Steppan; Kai-Uwe Eckardt; Stefano Stuard; Luca Neri
Publié dans: International Journal of Environmental Research and Public Health,, Numéro Vol 18, Iss 12649, 2021, Page(s) p 12649, ISSN 1660-4601
Éditeur: MDPI
DOI: 10.3390/ijerph182312649

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens.

Auteurs: Dominik Kylies, Marina Zimmermann, Fabian Haas, Maria Schwerk, Malte Kuehl, Michael Brehler, Jan Czogalla, Lola C Hernandez, Leonie Konczalla, Yusuke Okabayashi, Julia Menzel, Ilka Edenhofer, Sam Mezher, Hande Aypek, Bernhard Dumoulin, Hui Wu, Smilla Hofmann, Oliver Kretz, Nicola Wanner, Nicola M Tomas, Susanne Krasemann, Markus Glatzel, Christoph Kuppe, Rafael Kramann, Bella Banjanin, Rebekka K S
Publié dans: Nature Nanotechnology, Numéro Apr;18(4), 2023, Page(s) 336-342, ISSN 1748-3387
Éditeur: Nature Publishing Group
DOI: 10.1038/s41565-023-01328-z

Epigenome-Wide Histone Acetylation Changes in Peripheral Blood Mononuclear Cells in Patients with Type 2 Diabetes and Atherosclerotic Disease

Auteurs: Pradeep Bompada, Isabel Goncalves , Chuanyan Wu, Rui Gao, Jiangming Sun, Bilal Ahmad Mir, Cheng Luan, Erik Renström, Leif Groop, Jianping Weng, Ola Hansson, Jianping Weng, Ola Hansson, Andreas Edsfeldt, Yang De Marinis
Publié dans: Biomedicines, Numéro 22279059, 2021, ISSN 2227-9059
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9121908

Kv1.3 Channel, a Targetable Piece in the Complex Jigsaw Puzzle of Vascular Calcification?

Auteurs: Maria F Gomez
Publié dans: Function, Numéro 2/1, 2021, ISSN 2633-8823
Éditeur: Oxford University Press
DOI: 10.1093/function/zqaa049

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease

Auteurs: Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K Giri, Rashmi B Prasad, Rishi Das Roy, Lena M Thorn, Antti Rannikko, Harry Holthöfer, Kim M Gooding, Steven Sourbron, Denis Delic, Maria F Gomez; iBEAt; Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka
Publié dans: iScience, Numéro 26, 2023, Page(s) 106686, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2023.106686

A novel drug response score more accurately predicts renoprotective drug effects than existing renal risk scores

Auteurs: Nienke M. A. Idzerda, Sok Cin Tye, Dick de Zeeuw, Hiddo J. L. Heerspink
Publié dans: Therapeutic Advances in Endocrinology and Metabolism, Numéro 12, 2021, ISSN 2042-0188
Éditeur: Sage Periodicals Press
DOI: 10.1177/2042018820974191

Correlates and Consequences of an Acute Change in eGFR in Response to the SGLT2 Inhibitor Dapagliflozin in Patients with CKD

Auteurs: Niels Jongs; Glenn M. Chertow; Tom Greene; John J.V. McMurray; Anna Maria Langkilde; Ricardo Correa-Rotter; Naoki Kashihara; Peter Rossing; C. David Sjöström; Bergur V. Stefánsson; Robert D. Toto; David C. Wheeler; Hiddo J.L. Heerspink
Publié dans: J Am Soc Nephrol, Numéro 33(11), 2023, Page(s) 2094-2107, ISSN 1533-3450
Éditeur: ASN
DOI: 10.1681/asn.2022030306

Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review

Auteurs: Sara Denicolò, Paul Perco, Stefanie Thöni, Gert Mayer
Publié dans: J Diabetes Compl, Numéro Vol 35, Numéro 7, 2021, Page(s) 107931, ISSN 1873-460X
Éditeur: Elsevier
DOI: 10.1016/j.jdiacomp.2021.107931

BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk.

Auteurs: Bork T, Liang W, Kretz O, Lagies S, Yamahara K, Hernando-Erhard C, Helmstädter M, Schell C, Kammerer B, Huber TB
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2022, Page(s) 3825, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073825

Vallidation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial.

Auteurs: Marie Pigeyre, Sibylle Hess, Maria F Gomez, Olof Asplund, Leif Groop, Guillaume Paré, Hertzel Gerstein.
Publié dans: Diabetologia, Numéro 65, 2022, Page(s) 206-215, ISSN 1432-0428
Éditeur: Springer
DOI: 10.1007/s00125-021-05567-4

Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes

Auteurs: Skander Mulder, Paul Perco, Christina Oxlund, Uzma F. Mehdi, Thomas Hankemeier, Ib A. Jacobsen, Robert Toto, Hiddo J.L. Heerspink, Michelle J. Pena
Publié dans: Translational Research, Numéro 222, 2020, Page(s) 17-27, ISSN 1931-5244
Éditeur: Elsevier BV
DOI: 10.1016/j.trsl.2020.04.010

International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe

Auteurs: Stefanie Thöni, Felix Keller, Sara Denicolò, Susanne Eder, Lukas Buchwinkler, Laszlo Rosivall, Andrzej Wiecekc, Patrick B. Mark, Peter Rossinge, Hiddo L. Heerspink, Gert Mayer
Publié dans: Kidney & Blood Pressure Research, Numéro 48, 2023, Page(s) 165–174, ISSN 1420-4096
Éditeur: S. Karger AG
DOI: 10.1159/000528438

Prediction of the Effects of Liraglutide on Kidney and Cardiovascular Outcomes Based on Short-Term Changes in Multiple Risk Markers

Auteurs: Sok Cin Tye, Sieta T. de Vries, Johannes F. E. Mann, Meir Schechter, Ofri Mosenzon, Petra Denig and Hiddo J. L. Heerspink
Publié dans: Frontiers in Pharmacology, Numéro 16639812, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.786767

Prediction of the Effects of Empagliflozin on Cardiovascular and Kidney Outcomes Based onShort-Term Changes in Multiple Risk Markers

Auteurs: Sok Cin Tye, Sieta T. de Vries, Christoph Wanner, Petra Denig and Hiddo J. L. Heerspink
Publié dans: Frontiers in Pharmacology, Numéro 16639812, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.786706

Precision Prognostics for Cardiovascular Disease in Type 2 Diabetes: A Systematic Review and Meta-analysis

Auteurs: Abrar Ahmad, Lee-Ling Lim, Mario Luca Morieri, Claudia Ha-ting Tam, Feifei Cheng , Tinashe Chikowore, Monika Dudenhöffer-Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert Wilhelm Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. de Souza, Deirdre Kay Tobias, ADA/EASD PMDI23, Maria F. Gomez, Ronald C.W. Ma
Publié dans: Comm Medicine, Numéro 4/11, 2024, ISSN 2730-664X
Éditeur: Nature Portfolio
DOI: 10.1038/s43856-023-00429-z

Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Auteurs: Ilona A. Dekkers, Anneloes de Boer, Kaniska Sharma, Eleanor F. Cox, Hildo J. Lamb, David L. Buckley, Octavia Bane, David M. Morris, Pottumarthi V. Prasad, Scott I. K. Semple, Keith A. Gillis, Paul Hockings, Charlotte Buchanan, Marcos Wolf, Christoffer Laustsen, Tim Leiner, Bryan Haddock, Johannes M. Hoogduin, Pim Pullens, Steven Sourbron, Susan Francis
Publié dans: Magnetic Resonance Materials in Physics, Biology and Medicine, Numéro 33/1, 2020, Page(s) 163-176, ISSN 0968-5243
Éditeur: Springer Verlag
DOI: 10.1007/s10334-019-00797-5

Role of mTOR Signaling for Tubular Function and Disease

Auteurs: Grahammer F, Huber TB, Artunc F.
Publié dans: Physiology (Bethesda), Numéro 15489213, 2021, Page(s) 350-358, ISSN 1548-9213
Éditeur: American Physiological Society
DOI: 10.1152/physiol.00021.2021

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol

Auteurs: Kim M. Gooding, Chrysta Lienczewski, Massimo Papale, Niina Koivuviita, Marlena Maziarz, Anna-Maria Dutius Andersson, Kanishka Sharma, Paola Pontrelli, Alberto Garcia Hernandez, Julie Bailey, Kay Tobin, Virva Saunavaara, Anna Zetterqvist, David Shelley, Irvin Teh, Claire Ball, Sapna Puppala, Mark Ibberson, Anil Karihaloo, Kaj Metsärinne, Rosamonde E. Banks, Peter S. Gilmour, Michael Mansfield, Mar
Publié dans: BMC Nephrology, Numéro 21/1, 2020, ISSN 1471-2369
Éditeur: BioMed Central
DOI: 10.1186/s12882-020-01901-x

Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF)

Auteurs: Matthew M.Y. Lee, Katriona J.M. Brooksbank, Kirsty Wetherall, Kenneth Mangion, Giles Roditi, Ross T. Campbell, Colin Berry, Victor Chong, Liz Coyle, Kieran F. Docherty, John G. Dreisbach, Catherine Labinjoh, Ninian N. Lang, Vera Lennie, Alex McConnachie, Clare L. Murphy, Colin J. Petrie, John R. Petrie, Iain A. Speirits, Steven Sourbron, Paul Welsh, Rosemary Woodward, Aleksandra Radjenovic, Patric
Publié dans: Circulation, Numéro 143/6, 2021, Page(s) 516–525, ISSN 0009-7322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.052186

Intra-individual variability of eGFR trajectories in early diabetic kidney disease and lack of performance of prognostic biomarkers

Auteurs: Julia Kerschbaum, Michael Rudnicki, Alexander Dzien, Christine Dzien-Bischinger, Hannes Winner, Hiddo Lambers Heerspink, László Rosivall, Andrzej Wiecek, Patrick B. Mark, Susanne Eder, Sara Denicolò, Gert Mayer
Publié dans: Scientific Reports, Numéro 10, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-76773-0

The Cardiovascular Literature-Based Risk Algorithm (CALIBRA): Predicting Cardiovascular Events in Patients With Non-Dialysis Dependent Chronic Kidney Disease

Auteurs: Luca, Neri; Caterina, Lonati; Jasmine Ion, Titapiccolo; Jennifer, Nadal; Heike, Meiselbach; Matthias, Schmid; Barbara, Baerthlein; Ulrich, Tschulena; Markus P, Schneider; Ulla T, Schultheiss; Carlo, Barbieri; Christoph, Moore; Sonia, Steppan; Kai-Uwe, Eckardt; Stefano, Stuard; Francesco, Bellocchio
Publié dans: Front Nephrol, Numéro 2, 2022, Page(s) 922251, ISSN 2813-0626
Éditeur: Frontiers Media SA
DOI: 10.3389/fneph.2022.922251

Large Between-Patient Variability in eGFR Decline before Clinical Trial Enrollment and Impact on Atrasentan’s Efficacy: A Post Hoc Analysis from the SONAR Trial

Auteurs: Simke W. Waijer, Sieta T. de Vries, Robert Busch, Di Xie, Ron T. Gansevoort, Fan Fan Hou, Jose L. Górriz, Gozewijn D. Laverman, Luca De Nicola, Julio Pascual, Michele Provenzano, Pablo E. Pergola, Sydney C.W. Tang, Christoph Wanner, Philippe Zaoui, Hans-Henrik Parving, Dick de Zeeuw and Hiddo J.L. Heerspink
Publié dans: Journal of the American Society of Nephrology, Numéro 32 (11), 2021, Page(s) 2731-2734, ISSN 1046-6673
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021040498

Clonal Hematopoiesis of Indeterminate Potential and Diabetic Kidney Disease: A Nested Case-Control Study.

Auteurs: Sara Denicolò, Verena Vogi, Felix Keller, Stefanie Thöni, Susanne Eder, Hiddo J.L. Heerspink , László Rosivall, Andrzej Wiecek, Patrick B. Mark, Paul Perco, Johannes Leierer, Andreas Kronbichler, Marion Steger, Simon Schwendinger, Johannes Zschocke, Gert Mayer, Emina Jukic
Publié dans: Kidney International Reports, Numéro 24680249, 2022, Page(s) 876-888, ISSN 2468-0249
Éditeur: Elsevier
DOI: 10.1016/j.ekir.2022.01.1064

Inhibition of Lysine 63 ubiquitination prevents the progression of renal fibrosis in diabetic DBA/2J mice.

Auteurs: Paola Pontrelli, Francesca Conserva, Rossella Menghini, Michele Rossini, Alessandra Stasi, Chiara Divella, Viviana Casagrande, Claudia Cinefra, Mariagrazia Barozzino, Simona Simone, Francesco Pesce, Giuseppe Castellano, Giovanni Stallone, Anna Gallone, Francesco Giorgino, Massimo Federici and Loreto Gesualdo
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2021, Page(s) 5194, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105194

The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study

Auteurs: Simona Hapca, Moneeza K. Siddiqui, Ryan S.Y. Kwan, Michelle Lim, Shona Matthew, Alex S.F. Doney, Ewan R. Pearson, Colin N.A. Palmer, Samira Bell
Publié dans: Journal of the American Society of Nephrology, Numéro 32/1, 2020, Page(s) 138-150, ISSN 1046-6673
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A reciprocal regulation of spermidine and autophagy in podocytes maintains the filtration barrier

Auteurs: Wei Liang, Kosuke Yamahara, Camila Hernando-Erhard, Simon Lagies, Nicola Wanner, Huan Liang, Christoph Schell, Bernd Kammerer, Tobias B. Huber, Tillmann Bork
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An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles.

Auteurs: Karina Barreiro, Abigail C Lay, German Leparc, Van Du T Tran, Marcel Rosler, Lusyan Dayalan, Frederic Burdet, Mark Ibberson, Richard J M Coward, Tobias B Huber, Bernhard K Krämer, Denis Delic, Harry Holthofer
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Increased rejection rates in kidney transplantations during the COVID-19 pandemic

Auteurs: Schmidt-Lauber C, Spoden M, Huber TB, Günster C, Grahammer F.
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Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs

Auteurs: Francesca Solagna, Caterina Tezze, Maja T. Lindenmeyer, Shun Lu, Guochao Wu, Shuya Liu, Yu Zhao, Robert Mitchell, Charlotte Meyer, Saleh Omairi, Temel Kilic, Andrea Paolini, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Dominik Kylies, Julian Schulze zur Wiesch, Jan-Eric Turner, Nicola Wanner, Viji Nair, Felix Eichinger, Rajasree Menon, Ina V. Martin, Barbara M. Klinkhammer, Elion Hoxha, Clemen
Publié dans: The Journal of Clinical Investigation, Numéro 131/11, 2021, ISSN 0021-9738
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mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

Auteurs: Victor G. Puelles, James W. van der Wolde, Nicola Wanner, Markus W. Scheppach, Luise A. Cullen-McEwen, Tillmann Bork, Maja T. Lindenmeyer, Lukas Gernhold, Milagros N. Wong, Fabian Braun, Clemens D. Cohen, Michelle M. Kett, Christoph Kuppe, Rafael Kramann, Turgay Saritas, Claudia R. van Roeyen, Marcus J. Moeller, Leon Tribolet, Richard Rebello, Yu B.Y. Sun, Jinhua Li, Gerard Müller-Newen, Michael
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Bias and Precision in Magnetic Resonance Imaging-Based Estimates of Renal Blood Flow: Assessment by Triangulation

Auteurs: Bashair A. Alhummiany, David Shelley, Margaret Saysell, Maria-Alexandra Olaru, Bernd Kühn P, David L. Buckley, Julie Bailey, Kelly Wroe, Cherry Coupland, Michael W. Mansfield, Steven P. Sourbron, Kanishka Sharma
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Precision medicine in regulatory decision making: Biomarkers used for patient selection in European Public Assessment Reports from 2018 to 2020

Auteurs: Elisabeth Bakker, Viktoriia Starokozhko, Jet W M Kraaijvanger, Hiddo J L Heerspink, Peter G M Mol
Publié dans: Clinical and Translational Science, Numéro Nov;16(11), 2023, Page(s) 2394-2412, ISSN 1752-8054
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Consensus-based technical recommendations for clinical translation of renal ASL MRI

Auteurs: Fabio Nery, Charlotte E. Buchanan, Anita A. Harteveld, Aghogho Odudu, Octavia Bane, Eleanor F. Cox, Katja Derlin, H. Michael Gach, Xavier Golay, Marcel Gutberlet, Christoffer Laustsen, Alexandra Ljimani, Ananth J. Madhuranthakam, Ivan Pedrosa, Pottumarthi V. Prasad, Philip M. Robson, Kanishka Sharma, Steven Sourbron, Manuel Taso, David L. Thomas, Danny J. J. Wang, Jeff L. Zhang, David C. Alsop, Se
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Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Auteurs: Alexandra Ljimani, Anna Caroli, Christoffer Laustsen, Susan Francis, Iosif Alexandru Mendichovszky, Octavia Bane, Fabio Nery, Kanishka Sharma, Andreas Pohlmann, Ilona A. Dekkers, Jean-Paul Vallee, Katja Derlin, Mike Notohamiprodjo, Ruth P. Lim, Stefano Palmucci, Suraj D. Serai, Joao Periquito, Zhen Jane Wang, Martijn Froeling, Harriet C. Thoeny, Pottumarthi Prasad, Moritz Schneider, Thoralf Niendo
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Should we enlarge the indication for kidney biopsy in patients with diabetes? The pro part.

Auteurs: Loreto Gesualdo, Marco Fiorentino, Francesca Conserva, Paola Pontrelli
Publié dans: Clin Kidney J, Numéro 17(1), 2024, Page(s) 1-4, ISSN 2048-8513
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SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance

Auteurs: Manuel Rogg, Jasmin I. Maier, Robert Dotzauer, Nadine Artelt, Oliver Kretz, Martin Helmstädter, Ahmed Abed, Alena Sammarco, August Sigle, Dominik Sellung, Patrick Dinse, Karoline Reiche, Mako Yasuda-Yamahara, Martin L. Biniossek, Gerd Walz, Martin Werner, Nicole Endlich, Oliver Schilling, Tobias B. Huber, Christoph Schell
Publié dans: American Society of Nephrology, Numéro 32 (3), 2021, Page(s) 563-579, ISSN 1046-6673
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Initiation of the SGLT2 inhibitor canagliflozin to prevent kidney and cardiovascular outcomes guided by HbA1c, albuminuria, and predicted risk of kidney failure

Auteurs: Sok Cin Tye, Niels Jongs, Steven G. Coca, Johan Sundström, Clare Arnott, Bruce Neal, Vlado Perkovic, Kenneth W. Mahafey, Priya Vart and Hiddo. J. L. Heerspink
Publié dans: Cardiovascular Diabetology, Numéro 21, Article number: 194 (2022), 2022, ISSN 1475-2840
Éditeur: BioMed Central
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Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes

Auteurs: Taha Sen, Wenjun Ju, Viji Nair, Patricia Ladd, Rajasree Menon, Edgar A Otto, Laura Pyle, Tim Vigers, Robert G Nelson, Clare Arnott, Bruce Neal, Michael K Hansen, Matthias Kretzler, Petter Bjornstad, Hiddo J L Heerspink 
Publié dans: Kidney International, Numéro Oct;104(4), 2023, Page(s) 828-839, ISSN 0085-2538
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Mechanisms of action of the sodium-glucose cotransporter-2 (SGLT2) inhibitor canagliflozin on tubular inflammation and damage: A post hoc mediation analysis of the CANVAS trial

Auteurs: Taha Sen, Akihiko Koshino, Bruce Neal, Maarten J. Bijlsma, Clare Arnott, Jingwei Li, Michael K. Hansen, Joachim H. Ix, Hiddo J. L. Heerspink
Publié dans: Diabetes, Obesity and Metabolism, Numéro 14628902, 2022, Page(s) 1950-1956, ISSN 1462-8902
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Association between TNF Receptors and KIM-1 with Kidney Outcomes in Early-Stage Diabetic Kidney Disease

Auteurs: Simke W. Waijer, Taha Sen, Clare Arnott, Bruce Neal, Jos G.W. Kosterink, Kenneth W. Mahaffey, Chirag R. Parikh, Dick de Zeeuw, Vlado Perkovic, Brendon L. Neuen, Steven G. Coca, Michael K. Hansen, Ron T. Gansevoort and Hiddo J.L. Heerspink
Publié dans: Clinical Journal of the American Society of Nephrology, Numéro 15559041, 2022, Page(s) 251-259, ISSN 1555-9041
Éditeur: American Society of Nephrology
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Comparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease

Auteurs: Karina Barreiro, Om Prakash Dwivedi, German Leparc, Marcel Rolser, Denis Delic, Carol Forsblom, Per-Henrik Groop, Leif Groop, Tobias B. Huber, Maija Puhka, Harry Holthofer
Publié dans: Journal of Extracellular Vesicles, Numéro 10/2, 2020, ISSN 2001-3078
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An integrated organoid omics map extends modeling potential of kidney disease

Auteurs: Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria
Publié dans: Nature Communications, Numéro 14, Article number: 4903, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-39740-7

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

Auteurs: Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton,James W. Dear, Juan M. Falcón-Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge
Publié dans: Journal of Extracellular Vesicles, Numéro 10/7, 2021, ISSN 2001-3078
Éditeur: Taylor & Francis Group
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A metabolomics‐based molecular pathway analysis of how the sodium‐glucose co‐transporter‐2 inhibitor dapagliflozin may slow kidney function decline in patients with diabetes

Auteurs: Skander Mulder, Ann Hammarstedt, Sunil B. Nagaraj, Viji Nair, Wenjun Ju, Jonatan Hedberg, Peter J. Greasley, Jan W. Eriksson, Jan Oscarsson, Hiddo J. L. Heerspink
Publié dans: Diabetes, Obesity and Metabolism, Numéro 22/7, 2020, Page(s) 1157-1166, ISSN 1462-8902
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Recent advances in drug discovery for diabetic kidney disease

Auteurs: Chhanda Charan Danta, Andrew N. Boa, Sunil Bhandari, Thozhukat Sathyapalan, Shang-Zhong Xu
Publié dans: Expert Opinion on Drug Discovery, Numéro Vol 16, Numéro 4, 2021, Page(s) 447-461, ISSN 1746-045X
Éditeur: Taylor & Francis
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Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy.

Auteurs: Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F.
Publié dans: Journal of Clinical Investigation, Numéro 00219738, 2022, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
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A prediction model for the decline in renal function in people with type 2 diabetes mellitus: study protocol

Auteurs: Mariella Gregorich, Andreas Heinzel, Michael Kammer, Heike Meiselbach, Carsten A. Böger, Kai-Uwe Eckardt, Gert Mayer, Georg Heinze, Rainer Oberbauer
Publié dans: Diagnostic and Prognostic Research, Numéro 23977523, 2021, ISSN 2397-7523
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Primary decidual zone formation requires Scribble for pregnancy success in mice

Auteurs: Jia Yuan, Shizu Aikawa, Wenbo Deng, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B. Huber, Xiaofei Sun, Sudhansu K. Dey
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-13489-4

Renal vascular resistance is increased in patients with kidney transplant

Auteurs: Johanna Päivärinta, Vesa Oikonen, Anne Räisänen-Sokolowski, Tuula Tolvanen, Eliisa Löyttyniemi, Hidehiro Iida, Pirjo Nuutila, Kaj Metsärinne, Niina Koivuviita
Publié dans: BMC Nephrology, Numéro 20/1, 2019, ISSN 1471-2369
Éditeur: BioMed Central
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Special issue on magnetic resonance imaging biomarkers of renal disease

Auteurs: Paul Hockings, Christoffer Laustsen, Jaap A. Joles, Patrick B. Mark, Steven Sourbron
Publié dans: Magnetic Resonance Materials in Physics, Biology and Medicine, Numéro 33/1, 2020, Page(s) 1-2, ISSN 0968-5243
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Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine

Auteurs: Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulça Uluvar, Matthias Wuttke, Yurong Cheng, Arif B. Ekici, Gergely Gyimesi, Edward D Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F Gomez, Bing Yu, Morgan E Grams, Josef Coresh, Eric Boerwinkle, Michael Köttgen, Florian Kronenberg, Heike Meiselbach, Robert P Mohney, Shreeram A
Publié dans: Nat Genet, Numéro 55, 2023, Page(s) 995-1008, ISSN 1546-1718
Éditeur: Springer Nature Ltd
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Different roles of protein biomarkers predicting eGFR trajectories in people with chronic kidney disease and diabetes mellitus: a nationwide retrospective cohort study

Auteurs: Michael Kammer, Andreas Heinzel, Karin Hu, Heike Meiselbach, Mariella Gregorich, Martin Busch, Kevin L Duffin, Maria F Gomez, Kai-Uwe Eckardt, Rainer Oberbauer, BEAt-DKD consortium
Publié dans: Cardiovascular Diabetology, Numéro Mar 29;22(1), 2023, Page(s) 74, ISSN 1475-2840
Éditeur: BioMed Central
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The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier

Auteurs: Christoph Schell, Manuel Rogg, Martina Suhm, Martin Helmstädter, Dominik Sellung, Mako Yasuda-Yamahara, Oliver Kretz, Victoria Küttner, Hani Suleiman, Laxmikanth Kollipara, René P. Zahedi, Albert Sickmann, Stefan Eimer, Andrey S. Shaw, Albrecht Kramer-Zucker, Mariko Hirano-Kobayashi, Takaya Abe, Shinichi Aizawa, Florian Grahammer, Björn Hartleben, Jörn Dengjel, Tobias B. Huber
Publié dans: Proceedings of the National Academy of Sciences, Numéro 114/23, 2017, Page(s) E4621-E4630, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1617004114

YAP-mediated mechanotransduction determines the podocyte’s response to damage

Auteurs: Markus M. Rinschen, Florian Grahammer, Ann-Kathrin Hoppe, Priyanka Kohli, Henning Hagmann, Oliver Kretz, Sabine Bertsch, Martin Höhne, Heike Göbel, Malte P. Bartram, Rajesh Kumar Gandhirajan, Marcus Krüger, Paul-Thomas Brinkkoetter, Tobias B. Huber, Martin Kann, Sara A. Wickström, Thomas Benzing, Bernhard Schermer
Publié dans: Science Signaling, Numéro 10/474, 2017, Page(s) eaaf8165, ISSN 1937-9145
Éditeur: American Association for the Advancement of Science
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Targeting mTOR Signaling Can Prevent the Progression of FSGS

Auteurs: Stefan Zschiedrich, Tillmann Bork, Wei Liang, Nicola Wanner, Kristina Eulenbruch, Stefan Munder, Björn Hartleben, Oliver Kretz, Simon Gerber, Matias Simons, Amandine Viau, Martine Burtin, Changli Wei, Jochen Reiser, Nadja Herbach, Maria-Pia Rastaldi, Clemens D Cohen, Pierre-Louis Tharaux, Fabiola Terzi, Gerd Walz, Markus Gödel, Tobias B Huber
Publié dans: Journal of the American Society of Nephrology, Numéro 28/7, 2017, Page(s) 2144-2157, ISSN 1046-6673
Éditeur: Lippincott Williams & Wilkins Ltd.
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Renal trials in diabetes need a platform: time for a global approach?

Auteurs: Dick de Zeeuw, Hiddo J L Heerspink, Meg Jardine, Vlado Perkovic
Publié dans: The Lancet Diabetes & Endocrinology, Numéro 6/5, 2018, Page(s) 356-358, ISSN 2213-8587
Éditeur: Elsevier BV
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The Evolving Complexity of the Podocyte Cytoskeleton

Auteurs: Christoph Schell, Tobias B. Huber
Publié dans: Journal of the American Society of Nephrology, Numéro 28/11, 2017, Page(s) 3166-3174, ISSN 1046-6673
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ORAI channels are critical for receptor-mediated endocytosis of albumin

Auteurs: Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez, Shang-Zhong Xu
Publié dans: Nature Communications, Numéro 8/1, 2017, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-02094-y

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton

Auteurs: Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. Völker, Eva-Maria Schurek, Julie Binz, Martin Höhne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, Thomas Benzing
Publié dans: Journal of the American Society of Nephrology, Numéro 28/10, 2017, Page(s) 2867-2878, ISSN 1046-6673
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The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton

Auteurs: M. Rogg, M. Yasuda-Yamahara, A. Abed, P. Dinse, M. Helmstädter, A. C. Conzelmann, J. Frimmel, D. Sellung, M. L. Biniossek, O. Kretz, F. Grahammer, O. Schilling, T. B. Huber, C. Schell
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
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Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment

Auteurs: Luca Musante, Dorota Tataruch-Weinert, Dontscho Kerjaschki, Michael Henry, Paula Meleady, Harry Holthofer
Publié dans: Journal of Extracellular Vesicles, Numéro 6/1, 2017, Page(s) 1267896, ISSN 2001-3078
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Using the Drosophila Nephrocyte to Model Podocyte Function and Disease

Auteurs: Martin Helmstädter, Tobias B. Huber, Tobias Hermle
Publié dans: Frontiers in Pediatrics, Numéro 5, 2017, ISSN 2296-2360
Éditeur: Frontiers
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Renal biopsy-driven molecular target identification in glomerular disease

Auteurs: Maja T. Lindenmeyer, Matthias Kretzler
Publié dans: Pflügers Archiv - European Journal of Physiology, Numéro 469/7-8, 2017, Page(s) 1021-1028, ISSN 0031-6768
Éditeur: Springer Verlag
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Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

Auteurs: Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna Köttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wh
Publié dans: The Lancet, Numéro 390/10105, 2017, Page(s) 1888-1917, ISSN 0140-6736
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Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

Auteurs: Carole Henique, Guillaume Bollée, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, Léa Guyonnet, François Gaillard, Hélène Lazareth, Charlotte Meyer, Imane Bensaada, Luc Legrès, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet, Dominique Nochy, Tobias B. Huber, Laurent Mesnard, Olivia Lenoir, Pierre-Lo
Publié dans: Nature Communications, Numéro 8/1, 2017, ISSN 2041-1723
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FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology

Auteurs: M. Yasuda-Yamahara, M. Rogg, J. Frimmel, P. Trachte, M. Helmstaedter, P. Schroder, M. Schiffer, C. Schell, T.B. Huber
Publié dans: Matrix Biology, Numéro 68-69, 2018, Page(s) 263-279, ISSN 0945-053X
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Individual variability in response to renin angiotensin aldosterone system inhibition predicts cardiovascular outcome in patients with type 2 diabetes: A primary care cohort study

Auteurs: Ellen M. Apperloo, Michelle J. Pena, Dick de Zeeuw, Petra Denig, Hiddo J. L. Heerspink
Publié dans: Diabetes, Obesity and Metabolism, Numéro 20/6, 2018, Page(s) 1377-1383, ISSN 1462-8902
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Single-nephron proteomes connect morphology and function in proteinuric kidney disease

Auteurs: Martin Höhne, Christian K. Frese, Florian Grahammer, Claudia Dafinger, Giuliano Ciarimboli, Linus Butt, Julia Binz, Matthias J. Hackl, Mahdieh Rahmatollahi, Martin Kann, Simon Schneider, Mehmet M. Altintas, Bernhard Schermer, Thomas Reinheckel, Heike Göbel, Jochen Reiser, Tobias B. Huber, Rafael Kramann, Tamina Seeger-Nukpezah, Max C. Liebau, Bodo B. Beck, Thomas Benzing, Andreas Beyer, Markus M
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Endogenous factors and mechanisms of renoprotection and renal repair

Auteurs: Paul Perco, Gert Mayer
Publié dans: European Journal of Clinical Investigation, Numéro 48/5, 2018, Page(s) e12914, ISSN 0014-2972
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New clinical trial designs for establishing drug efficacy and safety in a precision medicine era

Auteurs: Hiddo J. L. Heerspink, James List, Vlado Perkovic
Publié dans: Diabetes, Obesity and Metabolism, Numéro 20, 2018, Page(s) 14-18, ISSN 1462-8902
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Implementing personalized medicine in diabetic kidney disease: Stakeholders' perspectives

Auteurs: Jeroen K. de Vries, Adeera Levin, Fiona Loud, Amanda Adler, Gert Mayer, Michelle J. Pena
Publié dans: Diabetes, Obesity and Metabolism, Numéro 20, 2018, Page(s) 24-29, ISSN 1462-8902
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Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Auteurs: Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Publié dans: The Lancet Diabetes & Endocrinology, Numéro 6/5, 2018, Page(s) 361-369, ISSN 2213-8587
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Precision medicine in diabetes and diabetic kidney disease: Regulatory considerations

Auteurs: Peter G. M. Mol, Aliza Thompson, Hiddo J. L. Heerspink, Hubert G. M. Leufkens
Publié dans: Diabetes, Obesity and Metabolism, Numéro 20, 2018, Page(s) 19-23, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.13453

An integrative systems biology approach for precision medicine in diabetic kidney disease

Auteurs: Skander Mulder, Habib Hamidi, Matthias Kretzler, Wenjun Ju
Publié dans: Diabetes, Obesity and Metabolism, Numéro 20, 2018, Page(s) 6-13, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.13416

Treating diabetic complications; from large randomized clinical trials to precision medicine

Auteurs: Hiddo J. L. Heerspink, Dick de Zeeuw
Publié dans: Diabetes, Obesity and Metabolism, Numéro 20, 2018, Page(s) 3-5, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.13418

Molecular, histological, and clinical phenotyping of diabetic nephropathy: valuable complementary information?

Auteurs: Paul Perco, Gert Mayer
Publié dans: Kidney International, Numéro 93/2, 2018, Page(s) 308-310, ISSN 0085-2538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2017.10.026

Systems biology approaches to identify disease mechanisms and facilitate targeted therapy in the management of glomerular disease

Auteurs: Habib Hamidi, Matthias Kretzler
Publié dans: Current Opinion in Nephrology and Hypertension, 2018, Page(s) 1, ISSN 1062-4821
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MNH.0000000000000446

N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk

Auteurs: Nienke M. A. Idzerda, Frederik Persson, Michelle J. Pena, Barry M. Brenner, Patrick Brunel, Nish Chaturvedi, John J. McMurray, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J. L. Heerspink
Publié dans: Diabetes, Obesity and Metabolism, 2018, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.13465

Novel avenues for drug discovery in diabetic kidney disease

Auteurs: Matthew D. Breyer, Matthias Kretzler
Publié dans: Expert Opinion on Drug Discovery, Numéro 13/1, 2017, Page(s) 65-74, ISSN 1746-0441
Éditeur: Informa Healthcare
DOI: 10.1080/17460441.2018.1398731

Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes

Auteurs: Andreas Heinzel, Michael Kammer, Gert Mayer, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B. Mark, Wenjun Ju, Matthias Kretzler, Peter Gilmour, Jonathan M. Wilson, Kevin L. Duffin, Moustafa Abdalla, Mark I. McCarthy, Georg Heinze, Hiddo L. Heerspink, Andrzej Wiecek, Maria F. Gomez, Rainer Oberbauer
Publié dans: Diabetes Care, Numéro 41/9, 2018, Page(s) 1947-1954, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc18-0532

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

Auteurs: Abigail C. Lay, Jenny A. Hurcombe, Virginie M. S. Betin, Fern Barrington, Ruth Rollason, Lan Ni, Lawrence Gillam, Grace M. E. Pearson, Mette V. Østergaard, Hellyeh Hamidi, Rachel Lennon, Gavin I. Welsh, Richard J. M. Coward
Publié dans: Diabetologia, Numéro 60/11, 2017, Page(s) 2299-2311, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-017-4394-0

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes

Auteurs: Markus M. Rinschen, Markus Gödel, Florian Grahammer, Stefan Zschiedrich, Martin Helmstädter, Oliver Kretz, Mostafa Zarei, Daniela A. Braun, Sebastian Dittrich, Caroline Pahmeyer, Patricia Schroder, Carolin Teetzen, HeonYung Gee, Ghaleb Daouk, Martin Pohl, Elisa Kuhn, Bernhard Schermer, Victoria Küttner, Melanie Boerries, Hauke Busch, Mario Schiffer, Carsten Bergmann, Marcus Krüger, Friedhelm H
Publié dans: Cell Reports, Numéro 23/8, 2018, Page(s) 2495-2508, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.04.059

Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA

Auteurs: Nicholas M Selby, Peter J Blankestijn, Peter Boor, Christian Combe, Kai-Uwe Eckardt, Eli Eikefjord, Nuria Garcia-Fernandez, Xavier Golay, Isky Gordon, Nicolas Grenier, Paul D Hockings, Jens D Jensen, Jaap A Joles, Philip A Kalra, Bernhard K Krämer, Patrick B Mark, Iosif A Mendichovszky, Olivera Nikolic, Aghogho Odudu, Albert C M Ong, Alberto Ortiz, Menno Pruijm, Giuseppe Remuzzi, Jarle Rørvik, S
Publié dans: Nephrology Dialysis Transplantation, Numéro 33/suppl_2, 2018, Page(s) ii4-ii14, ISSN 0931-0509
Éditeur: Oxford University Press
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Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials

Auteurs: Nienke M A Idzerda, Michelle J Pena, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J L Heerspink
Publié dans: Nephrology Dialysis Transplantation, 2018, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfy159

Personalized medicine in diabetic kidney disease

Auteurs: Nienke M.A. Idzerda, Michelle J. Pena, Hiddo J.L. Heerspink
Publié dans: Current Opinion in Nephrology and Hypertension, 2018, Page(s) 1, ISSN 1062-4821
Éditeur: Lippincott Williams & Wilkins Ltd.
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Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis

Auteurs: Ben Mellows, Robert Mitchell, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, Bernd Denecke, Luca Musante, Durrgah L. Ramachandra, Florence Debacq-Chainiaux, Harry Holthofer, Barbara Joch, Steve Ray, Darius Widera, Anna L. David, Tobias B. Huber, Joern Dengjel, Paolo De Coppi, Ketan Patel
Publié dans: Stem Cells and Development, Numéro 26/18, 2017, Page(s) 1316-1333, ISSN 1547-3287
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2017.0089

Urinary extracellular vesicles. A promising shortcut to novel biomarker discoveries

Auteurs: Karina Barreiro, Harry Holthofer
Publié dans: Cell and Tissue Research, Numéro 369/1, 2017, Page(s) 217-227, ISSN 0302-766X
Éditeur: Springer Verlag
DOI: 10.1007/s00441-017-2621-0

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Auteurs: Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad
Publié dans: Blood, Numéro 130/24, 2017, Page(s) 2664-2677, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2017-05-782102

Magnetic resonance imaging T1- and T2-mapping to assess renal structure and function: a systematic review and statement paper

Auteurs: Marcos Wolf, Anneloes de Boer, Kanishka Sharma, Peter Boor, Tim Leiner, Gere Sunder-Plassmann, Ewald Moser, Anna Caroli, Neil Peter Jerome
Publié dans: Nephrology Dialysis Transplantation, Numéro 33/suppl_2, 2018, Page(s) ii41-ii50, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfy198

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

Auteurs: Hans-Joachim Anders, Tobias B. Huber, Berend Isermann, Mario Schiffer
Publié dans: Nature Reviews Nephrology, Numéro 14/6, 2018, Page(s) 361-377, ISSN 1759-5061
Éditeur: Nature Publishing Group
DOI: 10.1038/s41581-018-0001-y

Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

Auteurs: Amandine Viau, Frank Bienaimé, Kamile Lukas, Abhijeet P Todkar, Manuel Knoll, Toma A Yakulov, Alexis Hofherr, Oliver Kretz, Martin Helmstädter, Wilfried Reichardt, Simone Braeg, Tom Aschman, Annette Merkle, Dietmar Pfeifer, Verónica I Dumit, Marie‐Claire Gubler, Roland Nitschke, Tobias B Huber, Fabiola Terzi, Jörn Dengjel, Florian Grahammer, Michael Köttgen, Hauke Busch, Melanie Boerries, G
Publié dans: The EMBO Journal, Numéro 37/15, 2018, Page(s) e98615, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.201798615

AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes

Auteurs: Mako Yasuda-Yamahara, Manuel Rogg, Kosuke Yamahara, Jasmin I. Maier, Tobias B. Huber, Christoph Schell
Publié dans: PLOS ONE, Numéro 13/7, 2018, Page(s) e0200487, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0200487

ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier

Auteurs: Christoph Schell, Benedikt Sabass, Martin Helmstaedter, Felix Geist, Ahmed Abed, Mako Yasuda-Yamahara, August Sigle, Jasmin I. Maier, Florian Grahammer, Florian Siegerist, Nadine Artelt, Nicole Endlich, Dontscho Kerjaschki, Hans-Henning Arnold, Jörn Dengjel, Manuel Rogg, Tobias B. Huber
Publié dans: Developmental Cell, Numéro 47/6, 2018, Page(s) 741-757.e8, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2018.11.011

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

Auteurs: Nicola Wanner, Julia Vornweg, Alexander Combes, Sean Wilson, Julia Plappert, Gesa Rafflenbeul, Victor G. Puelles, Raza-Ur Rahman, Timur Liwinski, Saskia Lindner, Florian Grahammer, Oliver Kretz, Mary E. Wlodek, Tania Romano, Karen M. Moritz, Melanie Boerries, Hauke Busch, Stefan Bonn, Melissa H. Little, Wibke Bechtel-Walz, Tobias B. Huber
Publié dans: Journal of the American Society of Nephrology, Numéro 30/1, 2018, Page(s) 63-78, ISSN 1046-6673
Éditeur: Lippincott Williams & Wilkins Ltd.
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Multimarker Panels in Diabetic Kidney Disease: The Way to Improved Clinical Trial Design and Clinical Practice?

Auteurs: Paul Perco, Michelle Pena, Hiddo J.L. Heerspink, Gert Mayer
Publié dans: Kidney International Reports, Numéro 4/2, 2019, Page(s) 212-221, ISSN 2468-0249
Éditeur: Elsevier
DOI: 10.1016/j.ekir.2018.12.001

The Evolving Importance of Insulin Signaling in Podocyte Health and Disease

Auteurs: Abigail C. Lay, Richard J. M. Coward
Publié dans: Frontiers in Endocrinology, Numéro 9, 2018, Page(s) 693, ISSN 1664-2392
Éditeur: Frontiers Media SA
DOI: 10.3389/fendo.2018.00693

A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies

Auteurs: Sara Gonçalves, Julie Patat, Maria Clara Guida, Noelle Lachaussée, Christelle Arrondel, Martin Helmstädter, Olivia Boyer, Olivier Gribouval, Marie-Claire Gubler, Geraldine Mollet, Marlène Rio, Marina Charbit, Christine Bole-Feysot, Patrick Nitschke, Tobias B. Huber, Patricia G. Wheeler, Devon Haynes, Jane Juusola, Thierry Billette de Villemeur, Caroline Nava, Alexandra Afenjar, Boris Keren, Ro
Publié dans: PLOS Genetics, Numéro 14/5, 2018, Page(s) e1007386, ISSN 1553-7404
Éditeur: Public Library of Science
DOI: 10.1371/journal.pgen.1007386

P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis

Auteurs: Laura Rennert, Stefan Zschiedrich, Lukas Sandner, Björn Hartleben, Sanja Cicko, Cemil Korcan Ayata, Charlotte Meyer, Andreas Zech, Robert Zeiser, Tobias B. Huber, Marco Idzko, Florian Grahammer
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01589

Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress

Auteurs: Kathryn L. Garner, Virginie M. S. Betin, Vanda Pinto, Mark Graham, Emmanuelle Abgueguen, Matt Barnes, David C. Bedford, Craig A. McArdle, Richard J. M. Coward
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-22233-9

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Auteurs: J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-08235-1

Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells

Auteurs: Banaja P. Dash, Tina M. Schnöder, Carolin Kathner, Juliane Mohr, Sönke Weinert, Carolin Herzog, Parimala Sonika Godavarthy, Costanza Zanetti, Florian Perner, Rüdiger Braun-Dullaeus, Björn Hartleben, Tobias B. Huber, Gerd Walz, Michael Naumann, Sarah Ellis, Valera Vasioukhin, Thilo Kähne, Daniela S. Krause, Florian H. Heidel
Publié dans: Journal of Cancer Research and Clinical Oncology, Numéro 144/10, 2018, Page(s) 1933-1944, ISSN 0171-5216
Éditeur: Springer Verlag
DOI: 10.1007/s00432-018-2724-3

Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease

Auteurs: Hiddo J. L. Heerspink, Paul Perco, Skander Mulder, Johannes Leierer, Michael K. Hansen, Andreas Heinzel, Gert Mayer
Publié dans: Diabetologia, Numéro 62/7, 2019, Page(s) 1154-1166, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-4859-4

Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers

Auteurs: Nienke M A Idzerda, Bergur V Stefansson, Michelle J Pena, David C Sjostrom, David C Wheeler, Hiddo J L Heerspink
Publié dans: Nephrology Dialysis Transplantation, 2019, ISSN 0931-0509
Éditeur: Oxford University Press
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Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

Auteurs: Paul T. Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Özel, Sybille Koehler, H. Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G. Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B. Huber
Publié dans: Cell Reports, Numéro 27/5, 2019, Page(s) 1551-1566.e5, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.04.012

Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease

Auteurs: Paul Perco, Wenjun Ju, Julia Kerschbaum, Johannes Leierer, Rajasree Menon, Catherine Zhu, Matthias Kretzler, Gert Mayer, Michael Rudnicki
Publié dans: JCI Insight, Numéro 4/12, 2019, ISSN 2379-3708
Éditeur: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.128120

Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles

Auteurs: Christian Koppelstaetter, Johannes Leierer, Michael Rudnicki, Julia Kerschbaum, Andreas Kronbichler, Anette Melk, Gert Mayer, Paul Perco
Publié dans: Computational and Structural Biotechnology Journal, Numéro 17, 2019, Page(s) 843-853, ISSN 2001-0370
Éditeur: Elsevier
DOI: 10.1016/j.csbj.2019.06.019

Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes

Auteurs: Skander Mulder, Hiddo J. L. Heerspink, Manjula Darshi, Jiwan J. Kim, Gozewijn D. Laverman, Kumar Sharma, Michelle J. Pena
Publié dans: Diabetes, Obesity and Metabolism, Numéro 21/11, 2019, Page(s) 2422-2428, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
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Mibefradil, a T‐type Ca 2+ channel blocker also blocks Orai channels by action at the extracellular surface

Auteurs: Pengyun Li, Hussein N. Rubaiy, Gui‐Lan Chen, Thomas Hallett, Nawel Zaibi, Bo Zeng, Rahul Saurabh, Shang‐Zhong Xu
Publié dans: British Journal of Pharmacology, Numéro 176/19, 2019, Page(s) 3845-3856, ISSN 0007-1188
Éditeur: Wiley-Blackwell
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Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes

Auteurs: Michael Kammer, Andreas Heinzel, Jill A. Willency, Kevin L. Duffin, Gert Mayer, Kai Simons, Mathias J. Gerl, Christian Klose, Georg Heinze, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B. Mark, Wenjun Ju, Matthias Kretzler, Mark I. McCarthy, Hiddo L. Heerspink, Andrzej Wiecek, Maria F. Gomez, Rainer Oberbauer
Publié dans: Kidney International, Numéro 96/6, 2019, Page(s) 1381-1388, ISSN 0085-2538
Éditeur: Blackwell Publishing Inc.
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Management of Tamm–Horsfall Protein for Reliable Urinary Analytics

Auteurs: Xiaomeng Xu, Karina Barreiro, Luca Musante, Oliver Kretz, Hanfei Lin, Hequn Zou, Tobias B. Huber, Harry Holthofer
Publié dans: PROTEOMICS – Clinical Applications, Numéro 13/6, 2019, Page(s) 1900018, ISSN 1862-8346
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
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Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy

Auteurs: Francesca Conserva, Mariagrazia Barozzino, Francesco Pesce, Chiara Divella, Annarita Oranger, Massimo Papale, Fabio Sallustio, Simona Simone, Luigi Laviola, Francesco Giorgino, Anna Gallone, Paola Pontrelli, Loreto Gesualdo
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
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Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

Auteurs: Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Publié dans: Journal of Cachexia, Sarcopenia and Muscle, Numéro 10/3, 2019, Page(s) 662-686, ISSN 2190-5991
Éditeur: Springer Verlag
DOI: 10.1002/jcsm.12404

Estimated lifetime benefit of novel pharmacological therapies in patients with type 2 diabetes and chronic kidney disease: A joint analysis of randomized controlled clinical trials

Auteurs: Hiddo J L Heerspink, Priya Vart, Niels Jongs, Brendon L Neuen, George Bakris, Brian Claggett, Muthiah Vaduganathan, Finnian McCausland, Kieran F Docherty, Pardeep S Jhund, Scott D Solomon, Vlado Perkovic, John J V McMurray
Publié dans: Diabetes, Obesity and Metabolism, Numéro Nov;25(11), 2023, Page(s) 3327-3336, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
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Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKD

Auteurs: Dominik Steubl, Markus P. Schneider, Heike Meiselbach, Jennifer Nadal, Matthias C. Schmid, Turgay Saritas, Vera Krane, Claudia Sommerer, Seema Baid-Agrawal, Jakob Voelkl, Fruzsina Kotsis, Anna Köttgen, Kai-Uwe Eckardt, Jürgen E. Scherberich
Publié dans: Clinical Journal of the American Society of Nephrology, Numéro 15/5, 2020, Page(s) 616-624, ISSN 1555-9041
Éditeur: American Society of Nephrology
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Metabolite Signature of Albuminuria Involves Amino Acid Pathways in 8661 Finnish Men Without Diabetes

Auteurs: Lilian Fernandes Silva, Jagadish Vangipurapu, Ulf Smith, Markku Laakso
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 106/1, 2020, Page(s) 143–152, ISSN 0021-972X
Éditeur: The Endocrine Society
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Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Auteurs: Octavia Bane, Iosif A. Mendichovszky, Bastien Milani, Ilona A. Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E. Hall, Tsutomu Inoue, Christoffer Laustsen, Lilach O. Lerman, Chunlei Liu, Glen Morrell, Michael Pedersen, Menno Pruijm, Elizabeth A. Sadowski, Erdmann Seeliger, Kanishka Sharma, Harriet Thoeny, Peter Vermathen, Zhen J. Wang, Zbigniew Serafin, Jeff L. Zhang, Susan T.
Publié dans: Magnetic Resonance Materials in Physics, Biology and Medicine, Numéro 33/1, 2020, Page(s) 199-215, ISSN 0968-5243
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Podocytes maintain high basal levels of autophagy independent of mtor signaling

Auteurs: Tillmann Bork, Wei Liang, Kosuke Yamahara, Philipp Lee, Zhejia Tian, Shuya Liu, Christoph Schell, Kathrin Thedieck, Bjoern Hartleben, Ketan Patel, Pierre-Louis Tharaux, Olivia Lenoir, Tobias B. Huber
Publié dans: Autophagy, 2019, Page(s) 1-17, ISSN 1554-8627
Éditeur: Landes Bioscience
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Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Auteurs: Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali
Publié dans: Nature Communications, Numéro 12, 2021, ISSN 2041-1723
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Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Auteurs: Deirdre K. Tobias, Jordi Merino, Abrar Ahmad, Catherine Aiken, Jamie L. Benham, Dhanasekaran Bodhini, Amy L. Clark, Kevin Colclough, Rosa Corcoy, Sara J. Cromer, Daisy Duan, Jamie L. Felton, Ellen C. Francis, Pieter Gillard, Véronique Gingras, Romy Gaillard, Eram Haider, Alice Hughes , Jennifer M. Ikle, Laura M. Jacobsen, Anna R. Kahkoska, Jarno L. T. Kettunen, Raymond J. Kreienkamp, Lee-Ling L
Publié dans: Nature Medicine, Numéro 29, 2023, Page(s) 2438–2457, ISSN 1078-8956
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A protocol for rat kidney normothermic machine perfusion and subsequent transplantation

Auteurs: Jan Czogalla,Florian Grahammer,Victor G. Puelles,Tobias B. Huber
Publié dans: Artificial Organs, Numéro 45/2, 2020, Page(s) 168-174, ISSN 0160-564X
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Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function.

Auteurs: Gavin I. Welsh; Abigail C Lay; Susan E. Quaggin; Jennifer A. Hurcombe; Richard J M Coward; Alexandra F. Barrington; James R. Woodgett; Lan Ni
Publié dans: FASEB BioAdvances, Vol 1, Iss 8, Pp 498-510 (2019), Numéro 3, 2019, ISSN 2573-9832
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Insulin resistance, kidney outcomes and effects of the endothelin receptor antagonist atrasentan in patients with type 2 diabetes and chronic kidney disease

Auteurs: J David Smeijer, Donald E Kohan, Peter Rossing, Ricardo Correa-Rotter, Adrian Liew, Sydney C W Tang, Dick de Zeeuw, Ron T Gansevoort, Wenjun Ju, Hiddo J Lambers Heerspink 
Publié dans: Cardiovascular Diabetology, Numéro Sep 16;22(1), 2023, Page(s) 251, ISSN 1475-2840
Éditeur: BioMed Central
DOI: 10.1186/s12933-023-01964-8

Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes: Results from DAPASALT and DIAMOND

Auteurs: Taha Sen, Rosalie Scholtes, Peter J. Greasley, David Z. I. Cherney, Claire C. J. Dekkers, Marc Vervloet, Alexander H. J. Danser, Sean J. Barbour, Cecilia Karlsson, Ann Hammarstedt, Qiang Li, Gozewijn D. Laverman, Petter Bjornstad, Daniel H. van Raalte, Hiddo J. L. Heerspink
Publié dans: Diabetes, Obesity and Metabolism, Numéro 14628902, 2022, Page(s) 1578-1587, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.14729

Recent findings on the clinical utility of renal magnetic resonance imaging biomarkers

Auteurs: Roslyn Simms, Steven Sourbron
Publié dans: Nephrology Dialysis Transplantation, Numéro 35/6, 2020, Page(s) 915-919, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfaa125

Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

Auteurs: Chuanjiang Yu, Sivahari P. Gorantla, Alina Müller-Rudorf, Tony A. Müller, Stefanie Kreutmair, Corinna Albers, Lena Jakob, Lena J. Lippert, Zhenyu Yue, Monika Engelhardt, Marie Follo, Robert Zeiser, Tobias B. Huber, Justus Duyster, Anna L. Illert
Publié dans: Haematologica, Numéro 105/5, 2020, Page(s) 1285-1293, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.212027

BET Proteins Regulate Expression of Osr1 in Early Kidney Development

Auteurs: Schreiber J, Liaukouskaya N, Fuhrmann L, Hauser AT, Jung M, Huber TB, Wanner N.
Publié dans: Biomedicines, Numéro 22279059, 2021, Page(s) 1878, ISSN 2227-9059
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9121878

Capturing the Kidney Transcriptome by Urinary Extracellular Vesicles—From Pre-Analytical Obstacles to Biomarker Research

Auteurs: Karina Barreiro, Om Prakash Dwivedi, Antti Rannikko, Harry Holthöfer, Tiinamaija Tuomi, Per-Henrik Groop, Maija Puhka
Publié dans: Genes, Numéro 14(7), 2023, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14071415

Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells

Auteurs: Nawel Zaibi, Pengyun Li, Shang-Zhong Xu
Publié dans: PLOS ONE, Numéro 19326203, 2021, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0247234

Deep learning–based molecular morphometrics for kidney biopsies

Auteurs: Marina Zimmermann, Martin Klaus, Milagros N. Wong, Ann-Katrin Thebille, Lukas Gernhold, Christoph Kuppe, Maurice Halder, Jennifer Kranz, Nicola Wanner, Fabian Braun, Sonia Wulf, Thorsten Wiech, Ulf Panzer, Christian F. Krebs, Elion Hoxha, Rafael Kramann, Tobias B. Huber, Stefan Bonn, Victor G. Puelles
Publié dans: JCI Insight, Numéro 6/7, 2021, ISSN 2379-3708
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.144779

Biomarker Qualification at the European Medicines Agency: A Review of Biomarker Qualification Procedures From 2008 to 2020

Auteurs: Elisabeth Bakker, Natalie M Hendrikse, Falk Ehmann, Daniëlla S van der Meer, Jordi Llinares Garcia, Thorsten Vetter, Viktoriia Starokozhko, Peter G M Mol
Publié dans: Clinical Pharmacology and Therapeutics, Numéro 00099236, 2022, Page(s) 69-80, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.2554

Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development

Auteurs: Fuhrmann L, Lindner S, Hauser AT, Höse C, Kretz O, Cohen CD, Lindenmeyer MT, Sippl W, Jung M, Huber TB, Wanner N
Publié dans: International Journal of Molecular Sciences, Numéro 22/8, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084157

The importance of targeting multiple risk markers in patients with type 2 diabetes: A post-hoc study from the CANVAS programme

Auteurs: SokCin Tye, Megumi Oshima, Clare Arnott, Brendon L. Neuen, Robert A. Fletcher, Bruce Neal, Hiddo J. L. Heerspink
Publié dans: Diabetes Obesity and Metabolism, Numéro 2023;1–8, 2023, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.15018

Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building Meeting

Auteurs: Elisabeth Bakker, Peter G. M. Mol, João Nabais, Thorsten Vetter, Matthias Kretzler, John J. Nolan, Gert Mayer, Anna K. Sundgren, Hiddo J. L. Heerspink, Anja Schiel, Sieta T. de Vries, Maria F. Gomez, Friedrich Schulze, Dick de Zeeuw, Michelle J. Pena
Publié dans: Frontiers in Pharmacology, 2021, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.662642

Dichotomous responses to chronic fetal hypoxia lead to a predetermined aging phenotype

Auteurs: Rudloff S, Bileck A, Janker L, Wanner N, Liaukouskaya N, Lundby C, Huber TB, Gerner C, Huynh-Do U
Publié dans: Molecular & Cellular Proteomics, Numéro 15359476, 2022, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2021.100190

Urinary extracellular vesicles: Assessment of pre-analytical variables and development of a quality control with focus on transcriptomic biomarker research

Auteurs: Karina Barreiro, Om Prakash Dwivedi Sami Valkonen, Per-Henrik Groop, Tiinamaija Tuomi, Harry Holthofer, Antti Rannikko, Marjo Yliperttula Pia Siljander, Saara Laitinen, Elina Serkkola, Taija af Hällström, Carol Forsblom, Leif Groop, Maija Puhka
Publié dans: Journal of extracellular vesicles, Numéro 20013078, 2021, ISSN 2001-3078
Éditeur: Wiley
DOI: 10.1002/jev2.12158

Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

Auteurs: Michael Crompton; Joanne K. Ferguson; Raina D. Ramnath; Karen L. Onions; Anna S. Ogier; Monica Gamez; Colin J. Down; Laura Skinner; Kitty H. Wong; Lauren K. Dixon; Judit Sutak; Steven J. Harper; Paola Pontrelli; Loreto Gesualdo; Hiddo L. Heerspink; Robert D. Toto; Gavin I. Welsh; Rebecca R. Foster; Simon C. Satchell; Matthew J. Butler
Publié dans: JCI Insight, Numéro 8(5), 2023, Page(s) e154164., ISSN 2379-3708
Éditeur: ASCI
DOI: 10.1172/jci.insight.154164

Organic Anion Transporter Gene Variants Associated with Plasma Exposure and Long-Term Response to Atrasentan in Patients With Diabetic Kidney Disease

Auteurs: J. David Smeijer, Jeroen V. Koomen, Donald E. Kohan, John J. V. McMurray, George L. Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, Dalane W. Kitzman, Hirofumi Makino, Gert Mayer, Michal Nowicki, Vlado Perkovic, Peter Rossing, Sheldon Tobe, Hans-Henrik Parving, Dick de Zeeuw and Hiddo J. L. Heerspink
Publié dans: Clinical Pharmacology and Therapeutics, Numéro 00099236, 2022, Page(s) 1098-1107, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.2721

Renal Perfusion, Oxygenation and Metabolism: The Role of Imaging

Auteurs: Johanna Päivärinta, Ioanna A Anastasiou, Niina Koivuviita, Kanishka Sharma, Pirjo Nuutila, Ele Ferrannini, Anna Solini, Eleni Rebelos
Publié dans: J Clin Med, Numéro 12(15), 2023, Page(s) 5141, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12155141

VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney

Auteurs: Markus M Rinschen, Jennifer L Harder, Madalina E Carter-Timofte, Luis Zanon Rodriguez, Carmen Mirabelli, Fatih Demir, Naziia Kurmasheva, Suresh K Ramakrishnan, Madlen Kunke, Yifan Tan, Anja Billing, Eileen Dahlke, Alexey A Larionov, Wibke Bechtel-Walz, Ute Aukschun, Marlen Grabbe, Rikke Nielsen, Erik I Christensen, Matthias Kretzler, Tobias B Huber, Christiane E Wobus, David O
Publié dans: Science Signaling, Numéro 2022 Nov 29;15(762), 2022, ISSN 1937-9145
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abo7940

Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure

Auteurs: J. David Smeijer, Jeroen Koomen, Donald E. Kohan, John J.V. McMurray, George L. Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, James L. Januzzi, Dalane W. Kitzman, Daniel M. Kolansky, Hirofumi Makino, Vlado Perkovic, Sheldon Tobe, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J.L. Heerspink
Publié dans: JACC Heart Fail, Numéro 22131779, 2022, Page(s) 498-507, ISSN 2213-1779
Éditeur: Elsevier BV
DOI: 10.1016/j.jchf.2022.03.004

Kidney outcome after mild to moderate COVID-19.

Auteurs: Christian Schmidt-Lauber, Sonja Hänzelmann, Stefan Schunk, Elina L Petersen, Ammar Alabdo, Maja Lindenmeyer, Fabian Hausmann, Piotr Kuta, Thomas Renné, Raphael Twerenbold, Tanja Zeller, Stefan Blankenberg, Danilo Fliser, Tobias B Huber
Publié dans: Nephrology Dialysis Transplantation, Numéro Aug 31;38(9), 2023, Page(s) 2031-2040, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfad008

Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL

Auteurs: Nienke M. A. Idzerda, Lindsay E. Clegg, Adrian F. Hernandez, George Bakris, Robert C. Penland, David W. Boulton, M. Angelyn Bethel, Rury R. Holman, Hiddo J. L. Heerspink
Publié dans: Diabetes, Obesity and Metabolism, Numéro 22/5, 2020, Page(s) 798-806, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.13958

IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

Auteurs: Abigail C. Lay, Lorna J. Hale, Holly Stowell-Connolly, Robert J. P. Pope, Viji Nair, Wenjun Ju, Eva Marquez, Ruth Rollason, Jenny A. Hurcombe, Bryony Hayes, Timothy Roberts, Lawrence Gillam, Jonathan Allington, Robert G. Nelson, Matthias Kretzler, Jeff M. P. Holly, Claire M. Perks, Craig A. McArdle, Gavin I. Welsh, Richard J. M. Coward
Publié dans: Diabetologia, Numéro 64, 2021, Page(s) 1690–1702, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-021-05427-1

The future of Diabetic Kidney Disease management: reducing the unmet need

Auteurs: Dick de Zeeuw
Publié dans: Journal of Nephrology, Numéro 33/6, 2020, Page(s) 1163-1169, ISSN 1121-8428
Éditeur: Wichtig Editore
DOI: 10.1007/s40620-020-00820-2

Thesis and dissertations (2)

Better prediction of drug response in diabetic kidney disease: a biomarker approach to personalize therapy

Auteurs: Nienke Idzerda
Publié dans: 2020
Éditeur: University of Groningen
DOI: 10.33612/diss.113117223

Urinary extracellular vesicles in diabetic kidney disease: ASSESSMENT OF PRE-ANALYTICAL VARIABLES AND IDENTIFICATION OF NOVEL CANDIDATE MARKERS

Auteurs: Karina Barreiro
Publié dans: 2023, ISBN 978-951-51-9201-1
Éditeur: Helsingin yliopisto

Book chapters (1)

Urinary Extracellular Vesicles Magic Particles for Biomarker Discovery

Auteurs: Karina Barreiro, Tobias B Huber, Harry Holthofer
Publié dans: Translational Urinomics, Numéro Advances in Experimental Medicine and Biology, vol 1306, 2021, ISBN 978-3-030-63908-2
Éditeur: Springer, Cham
DOI: 10.1007/978-3-030-63908-2_3