Biomarker Enterprise to Attack DKD - Sofia ref.: 115974 | BEAt-DKD | Project | Results | H2020 | CORDIS

Risultati finali

White paper on strengths and weaknesses of using biomarker panels (or multiple biomarker scores) as risk stratifiers, as targets in drug development and as surrogate endpoints for regulatory approval

Migration

Pubblicazioni

Predictive Biomarkers in Nephrology Around the Corner

Autori: Paul Perco, Kumar Sharma
Pubblicato in: Kidney International Reports, Numero 5/1, 2020, Pagina/e 1-3, ISSN 2468-0249
Editore: Elsevier
DOI: 10.1016/j.ekir.2019.10.009

Effects of albuminuria-lowering treatments on inflammation markers: A post hoc analysis from the ROTATE trials

Autori: Taha Sen, Viktor Rotbain Curovic, Niels Jongs, Gozewijn D Laverman, Adriaan Kooy, Frederik Persson, Peter Rossing, Hiddo J L Heerspink
Pubblicato in: Diabetes, Obesity and Metababolism, Numero Aug;25(8), 2023, Pagina/e 2413-2418, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.15109

Development and Validation of a Prediction Model for Future Estimated Glomerular Filtration Rate in People With Type 2 Diabetes and Chronic Kidney Disease

Autori: Mariella Gregorich, Michael Kammer, Andreas Heinzel, Carsten Böger, Kai-Uwe Eckardt, Hiddo Lambers Heerspink, Bettina Jung, Gert Mayer, Heike Meiselbach, Matthias Schmid,Ulla T. Schultheiss, Georg Heinze, Rainer Oberbauer, for the BEAt-DKD Consortium
Pubblicato in: JAMA Network Open, Numero 6(4), 2023, Pagina/e e231870, ISSN 0098-7484
Editore: American Medical Association
DOI: 10.1001/jamanetworkopen.2023.1870

Surprising Hyperkalemia of 10.2 mmol/L in a Patient with Hyperglycemia: A Case Report

Autori: Czogalla J, Tariparast P.A, Huber T.B, Janneck M, Grahammer F
Pubblicato in: Case Reports in Nephrology and Dialysis, Numero 11/1, 2021, Pagina/e 69–77, ISSN 2296-9705
Editore: S. Karger AG.
DOI: 10.1159/000512590

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

Autori: Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Pubblicato in: Genome Medicine, Numero Vol. 106, No. 2, 2023, Pagina/e 388–396, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-022-01145-4

Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis

Autori: Sara Denicolò, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Pubblicato in: Biomolecules, Numero 13(1), 89, 2023, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom13010089

Contribution of Real-World Evidence in European Medicines Agency's Regulatory Decision Making

Autori: Elisabeth Bakker, Kelly Plueschke, Carla J Jonker, Xavier Kurz, Viktoriia Starokozhko, Peter G M Mol
Pubblicato in: Clinical Pharmacology Therapeutics, Numero Jan;113(1), 2023, Pagina/e 135-151, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.2766

Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease—prospective data from the German Chronic Kidney Disease cohort

Autori: Johannes Ruhe, Jennifer Nadal, Barbara Bärthlein, Heike Meiselbach, Ulla T Schultheiss, Fruzsina Kotsis, Helena Stockmann, Vera Krane, Claudia Sommerer, Ivonne Löffler, Turgay Saritas, Jan T Kielstein, Thomas Sitter, Markus P Schneider, Matthias Schmid, Christoph Wanner, Kai-Uwe Eckardt, Gunter Wolf, Martin Busch
Pubblicato in: Clin Kidney J, Numero 16(11), 2023, Pagina/e 2032-2040, ISSN 2048-8505
Editore: Oxford University Press
DOI: 10.1093/ckj/sfad194

Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy

Autori: Fabian Braun, Ahmed Abed, Dominik Sellung, Manuel Rogg, Mathias Woidy, Oysten Eikrem, Nicola Wanner, Jessica Gambardella, Sandra D Laufer, Fabian Haas, Milagros N Wong, Bernhard Dumoulin, Paula Rischke, Anne Mühlig, Wiebke Sachs, Katharina von Cossel, Kristina Schulz, Nicole Muschol, Sören W Gersting, Ania C Muntau, Oliver Kretz, Oliver Hahn, Markus M Rinschen, Michael Mauer, Tillmann Bork, Flor
Pubblicato in: Journal of Clinical Investigation, Numero Jun 1;133(11), 2023, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci157782

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

Autori: Danielle Vaughan, Olli Ritvos, Robert Mitchell, Oliver Kretz, Maciej Lalowski, Helge Amthor, David Chambers, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Randy Ballesteros, Tobias B. Huber, Bernd Denecke, Darius Widera, Abir Mukherjee, Ketan Patel
Pubblicato in: European Journal of Translational Myology, Numero 30/1, 2020, Pagina/e 62-78, ISSN 2037-7460
Editore: PAGEPress Publications
DOI: 10.4081/ejtm.2019.8737

Differential prognostic utility of adiposity measures in chronic kidney disease

Autori: Vladimir Cejka, Jennifer Nadal, Matthias Schmid, Claudia Sommerer, Thomas Sitter, Heike Meiselbach. Martin Busch, Markus P Schneider, Turgay Saritas, Ulla T Schultheiss, Fruzsina Kotsis, Christoph Wanner, Kai-Uwe Eckardt, Vera Krane, GCKD Investigators.
Pubblicato in: J Renal Nutr, Numero 33(4), 2023, Pagina/e 546-554, ISSN 1532-8503
Editore: Saunders
DOI: 10.1053/j.jrn.2023.04.006

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis

Autori: Eva M Buhl, Sonja Djudjaj, Barbara M Klinkhammer, Katja Ermert, Victor G Puelles, Maja T Lindenmeyer, Clemens D Cohen, Chaoyong He, Erawan Borkham‐Kamphorst, Ralf Weiskirchen, Bernd Denecke, Panuwat Trairatphisan, Julio Saez‐Rodriguez, Tobias B Huber, Lorin E Olson, Jürgen Floege, Peter Boor
Pubblicato in: EMBO Molecular Medicine, Numero 12/3, 2020, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911021

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Autori: Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Gardar Sveinbjornsson, Thomas W Winkler, Felix Günther, Klaus J Stark, Jin-Fang Chai, Bamidele O Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle
Pubblicato in: Kidney international, Numero 102(3), 2022, Pagina/e 624-39, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2022.05.021

Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease

Autori: Raina D. Ramnath, Matthew J. Butler, Georgina Newman, Sara Desideri, Amy Russell, Abigail C. Lay, Chris R. Neal, Yan Qiu, Sarah Fawaz, Karen L. Onions, Monica Gamez, Michael Crompton, Chris Michie, Natalie Finch, Richard J. Coward, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell
Pubblicato in: Kidney International, Numero 97/5, 2020, Pagina/e 951-965, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2019.09.035

Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI

Autori: Anneloes de Boer MD,Giulia Villa MS,Octavia Bane PhD,Michael Bock PhD,Eleanor F. Cox PhD,Ilona A. Dekkers MD, PhD,Per Eckerbom MD,Maria A. Fernández-Seara PhD,Susan T. Francis PhD,Bryan Haddock PhD,Michael E. Hall MD,Pauline Hall Barrientos PhD,Ingo Hermann MS,Paul D. Hockings PhD,Hildo J. Lamb MD, PhD,Christoffer Laustsen PhD,Ruth P. Lim MD,David M. Morris PhD,Steffen Ringgaard PhD,Suraj D. Sera
Pubblicato in: Journal of Magnetic Resonance Imaging, 2020, ISSN 1053-1807
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmri.27419

Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

Autori: Iosif Mendichovszky, Pim Pullens, Ilona Dekkers, Fabio Nery, Octavia Bane, Andreas Pohlmann, Anneloes de Boer, Alexandra Ljimani, Aghogho Odudu, Charlotte Buchanan, Kanishka Sharma, Christoffer Laustsen, Anita Harteveld, Xavier Golay, Ivan Pedrosa, David Alsop, Sean Fain, Anna Caroli, Pottumarthi Prasad, Susan Francis, Eric Sigmund, Maria Fernández‐Seara, Steven Sourbron
Pubblicato in: Magnetic Resonance Materials in Physics, Biology and Medicine, Numero 33/1, 2020, Pagina/e 131-140, ISSN 0968-5243
Editore: Springer Verlag
DOI: 10.1007/s10334-019-00784-w

Interleukin-6 and Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes: New Insights From CANVAS

Autori: Akihiko Koshino, Meir Schechter, Taha Sen , Priya Vart, Brendon L Neuen, Bruce Neal, Clare Arnott , Vlado Perkovic, Paul M Ridker, Katherine R Tuttle, Michael K Hansen, Hiddo J L Heerspink
Pubblicato in: Diabetes Care, Numero Nov 1;45(11), 2022, Pagina/e 2644-2652, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc22-0866

Machine‐learning–based early prediction of end‐stage renal disease in patients with diabetic kidney disease using clinical trials data

Autori: Sunil Belur Nagaraj, Michelle J. Pena, Wenjun Ju, Hiddo L. Heerspink
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 22/12, 2020, Pagina/e 2479-2486, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.14178

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities

Autori: Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
Pubblicato in: Disease Models & Mechanisms, Numero 14/2, 2020, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.047555

Effect of empagliflozin on kidney biochemical and imaging outcomes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF)

Autori: Matthew M.Y. Lee, Keith A. Gillis, Katriona J.M. Brooksbank, Sarah Allwood-Spiers, Pauline Hall Barrientos, Kirsty Wetherall, Giles Roditi, Bashair AlHummiany, Colin Berry, Ross T. Campbell, Victor Chong, Liz Coyle, Kieran F. Docherty, John G. Dreisbach, Bernd Kuehn, Catherine Labinjoh, Ninian N. Lang, Vera Lennie, Kenneth Mangion, Alex McConnachie, Clare L. Murphy, Colin J. Petrie, John R. Petrie
Pubblicato in: Circulation, Numero 146, 2022, Pagina/e 364–367, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.059851

Validation of a Novel Predictive Algorithm for Kidney Failure in Patients Suffering from Chronic Kidney Disease: The Prognostic Reasoning System for Chronic Kidney Disease (PROGRES-CKD)

Autori: Francesco Bellocchio; Caterina Lonati; Jasmine Ion Titapiccolo; Jennifer Nadal; Heike Meiselbach; Matthias Schmid; Barbara Baerthlein; Ulrich Tschulena; Markus P. Schneider; Ulla T. Schultheiss; Carlo Barbieri; Christoph Moore; Sonja Steppan; Kai-Uwe Eckardt; Stefano Stuard; Luca Neri
Pubblicato in: International Journal of Environmental Research and Public Health,, Numero Vol 18, Iss 12649, 2021, Pagina/e p 12649, ISSN 1660-4601
Editore: MDPI
DOI: 10.3390/ijerph182312649

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens.

Autori: Dominik Kylies, Marina Zimmermann, Fabian Haas, Maria Schwerk, Malte Kuehl, Michael Brehler, Jan Czogalla, Lola C Hernandez, Leonie Konczalla, Yusuke Okabayashi, Julia Menzel, Ilka Edenhofer, Sam Mezher, Hande Aypek, Bernhard Dumoulin, Hui Wu, Smilla Hofmann, Oliver Kretz, Nicola Wanner, Nicola M Tomas, Susanne Krasemann, Markus Glatzel, Christoph Kuppe, Rafael Kramann, Bella Banjanin, Rebekka K S
Pubblicato in: Nature Nanotechnology, Numero Apr;18(4), 2023, Pagina/e 336-342, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-023-01328-z

Epigenome-Wide Histone Acetylation Changes in Peripheral Blood Mononuclear Cells in Patients with Type 2 Diabetes and Atherosclerotic Disease

Autori: Pradeep Bompada, Isabel Goncalves , Chuanyan Wu, Rui Gao, Jiangming Sun, Bilal Ahmad Mir, Cheng Luan, Erik Renström, Leif Groop, Jianping Weng, Ola Hansson, Jianping Weng, Ola Hansson, Andreas Edsfeldt, Yang De Marinis
Pubblicato in: Biomedicines, Numero 22279059, 2021, ISSN 2227-9059
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9121908

Kv1.3 Channel, a Targetable Piece in the Complex Jigsaw Puzzle of Vascular Calcification?

Autori: Maria F Gomez
Pubblicato in: Function, Numero 2/1, 2021, ISSN 2633-8823
Editore: Oxford University Press
DOI: 10.1093/function/zqaa049

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease

Autori: Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K Giri, Rashmi B Prasad, Rishi Das Roy, Lena M Thorn, Antti Rannikko, Harry Holthöfer, Kim M Gooding, Steven Sourbron, Denis Delic, Maria F Gomez; iBEAt; Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka
Pubblicato in: iScience, Numero 26, 2023, Pagina/e 106686, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2023.106686

A novel drug response score more accurately predicts renoprotective drug effects than existing renal risk scores

Autori: Nienke M. A. Idzerda, Sok Cin Tye, Dick de Zeeuw, Hiddo J. L. Heerspink
Pubblicato in: Therapeutic Advances in Endocrinology and Metabolism, Numero 12, 2021, ISSN 2042-0188
Editore: Sage Periodicals Press
DOI: 10.1177/2042018820974191

Correlates and Consequences of an Acute Change in eGFR in Response to the SGLT2 Inhibitor Dapagliflozin in Patients with CKD

Autori: Niels Jongs; Glenn M. Chertow; Tom Greene; John J.V. McMurray; Anna Maria Langkilde; Ricardo Correa-Rotter; Naoki Kashihara; Peter Rossing; C. David Sjöström; Bergur V. Stefánsson; Robert D. Toto; David C. Wheeler; Hiddo J.L. Heerspink
Pubblicato in: J Am Soc Nephrol, Numero 33(11), 2023, Pagina/e 2094-2107, ISSN 1533-3450
Editore: ASN
DOI: 10.1681/asn.2022030306

Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review

Autori: Sara Denicolò, Paul Perco, Stefanie Thöni, Gert Mayer
Pubblicato in: J Diabetes Compl, Numero Vol 35, Numero 7, 2021, Pagina/e 107931, ISSN 1873-460X
Editore: Elsevier
DOI: 10.1016/j.jdiacomp.2021.107931

BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk.

Autori: Bork T, Liang W, Kretz O, Lagies S, Yamahara K, Hernando-Erhard C, Helmstädter M, Schell C, Kammerer B, Huber TB
Pubblicato in: International Journal of Molecular Sciences, Numero 14220067, 2022, Pagina/e 3825, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073825

Vallidation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial.

Autori: Marie Pigeyre, Sibylle Hess, Maria F Gomez, Olof Asplund, Leif Groop, Guillaume Paré, Hertzel Gerstein.
Pubblicato in: Diabetologia, Numero 65, 2022, Pagina/e 206-215, ISSN 1432-0428
Editore: Springer
DOI: 10.1007/s00125-021-05567-4

Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes

Autori: Skander Mulder, Paul Perco, Christina Oxlund, Uzma F. Mehdi, Thomas Hankemeier, Ib A. Jacobsen, Robert Toto, Hiddo J.L. Heerspink, Michelle J. Pena
Pubblicato in: Translational Research, Numero 222, 2020, Pagina/e 17-27, ISSN 1931-5244
Editore: Elsevier BV
DOI: 10.1016/j.trsl.2020.04.010

International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe

Autori: Stefanie Thöni, Felix Keller, Sara Denicolò, Susanne Eder, Lukas Buchwinkler, Laszlo Rosivall, Andrzej Wiecekc, Patrick B. Mark, Peter Rossinge, Hiddo L. Heerspink, Gert Mayer
Pubblicato in: Kidney & Blood Pressure Research, Numero 48, 2023, Pagina/e 165–174, ISSN 1420-4096
Editore: S. Karger AG
DOI: 10.1159/000528438

Prediction of the Effects of Liraglutide on Kidney and Cardiovascular Outcomes Based on Short-Term Changes in Multiple Risk Markers

Autori: Sok Cin Tye, Sieta T. de Vries, Johannes F. E. Mann, Meir Schechter, Ofri Mosenzon, Petra Denig and Hiddo J. L. Heerspink
Pubblicato in: Frontiers in Pharmacology, Numero 16639812, 2022, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.786767

Prediction of the Effects of Empagliflozin on Cardiovascular and Kidney Outcomes Based onShort-Term Changes in Multiple Risk Markers

Autori: Sok Cin Tye, Sieta T. de Vries, Christoph Wanner, Petra Denig and Hiddo J. L. Heerspink
Pubblicato in: Frontiers in Pharmacology, Numero 16639812, 2022, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.786706

Precision Prognostics for Cardiovascular Disease in Type 2 Diabetes: A Systematic Review and Meta-analysis

Autori: Abrar Ahmad, Lee-Ling Lim, Mario Luca Morieri, Claudia Ha-ting Tam, Feifei Cheng , Tinashe Chikowore, Monika Dudenhöffer-Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert Wilhelm Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. de Souza, Deirdre Kay Tobias, ADA/EASD PMDI23, Maria F. Gomez, Ronald C.W. Ma
Pubblicato in: Comm Medicine, Numero 4/11, 2024, ISSN 2730-664X
Editore: Nature Portfolio
DOI: 10.1038/s43856-023-00429-z

Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Autori: Ilona A. Dekkers, Anneloes de Boer, Kaniska Sharma, Eleanor F. Cox, Hildo J. Lamb, David L. Buckley, Octavia Bane, David M. Morris, Pottumarthi V. Prasad, Scott I. K. Semple, Keith A. Gillis, Paul Hockings, Charlotte Buchanan, Marcos Wolf, Christoffer Laustsen, Tim Leiner, Bryan Haddock, Johannes M. Hoogduin, Pim Pullens, Steven Sourbron, Susan Francis
Pubblicato in: Magnetic Resonance Materials in Physics, Biology and Medicine, Numero 33/1, 2020, Pagina/e 163-176, ISSN 0968-5243
Editore: Springer Verlag
DOI: 10.1007/s10334-019-00797-5

Role of mTOR Signaling for Tubular Function and Disease

Autori: Grahammer F, Huber TB, Artunc F.
Pubblicato in: Physiology (Bethesda), Numero 15489213, 2021, Pagina/e 350-358, ISSN 1548-9213
Editore: American Physiological Society
DOI: 10.1152/physiol.00021.2021

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol

Autori: Kim M. Gooding, Chrysta Lienczewski, Massimo Papale, Niina Koivuviita, Marlena Maziarz, Anna-Maria Dutius Andersson, Kanishka Sharma, Paola Pontrelli, Alberto Garcia Hernandez, Julie Bailey, Kay Tobin, Virva Saunavaara, Anna Zetterqvist, David Shelley, Irvin Teh, Claire Ball, Sapna Puppala, Mark Ibberson, Anil Karihaloo, Kaj Metsärinne, Rosamonde E. Banks, Peter S. Gilmour, Michael Mansfield, Mar
Pubblicato in: BMC Nephrology, Numero 21/1, 2020, ISSN 1471-2369
Editore: BioMed Central
DOI: 10.1186/s12882-020-01901-x

Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF)

Autori: Matthew M.Y. Lee, Katriona J.M. Brooksbank, Kirsty Wetherall, Kenneth Mangion, Giles Roditi, Ross T. Campbell, Colin Berry, Victor Chong, Liz Coyle, Kieran F. Docherty, John G. Dreisbach, Catherine Labinjoh, Ninian N. Lang, Vera Lennie, Alex McConnachie, Clare L. Murphy, Colin J. Petrie, John R. Petrie, Iain A. Speirits, Steven Sourbron, Paul Welsh, Rosemary Woodward, Aleksandra Radjenovic, Patric
Pubblicato in: Circulation, Numero 143/6, 2021, Pagina/e 516–525, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.052186

Intra-individual variability of eGFR trajectories in early diabetic kidney disease and lack of performance of prognostic biomarkers

Autori: Julia Kerschbaum, Michael Rudnicki, Alexander Dzien, Christine Dzien-Bischinger, Hannes Winner, Hiddo Lambers Heerspink, László Rosivall, Andrzej Wiecek, Patrick B. Mark, Susanne Eder, Sara Denicolò, Gert Mayer
Pubblicato in: Scientific Reports, Numero 10, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-76773-0

The Cardiovascular Literature-Based Risk Algorithm (CALIBRA): Predicting Cardiovascular Events in Patients With Non-Dialysis Dependent Chronic Kidney Disease

Autori: Luca, Neri; Caterina, Lonati; Jasmine Ion, Titapiccolo; Jennifer, Nadal; Heike, Meiselbach; Matthias, Schmid; Barbara, Baerthlein; Ulrich, Tschulena; Markus P, Schneider; Ulla T, Schultheiss; Carlo, Barbieri; Christoph, Moore; Sonia, Steppan; Kai-Uwe, Eckardt; Stefano, Stuard; Francesco, Bellocchio
Pubblicato in: Front Nephrol, Numero 2, 2022, Pagina/e 922251, ISSN 2813-0626
Editore: Frontiers Media SA
DOI: 10.3389/fneph.2022.922251

Large Between-Patient Variability in eGFR Decline before Clinical Trial Enrollment and Impact on Atrasentan’s Efficacy: A Post Hoc Analysis from the SONAR Trial

Autori: Simke W. Waijer, Sieta T. de Vries, Robert Busch, Di Xie, Ron T. Gansevoort, Fan Fan Hou, Jose L. Górriz, Gozewijn D. Laverman, Luca De Nicola, Julio Pascual, Michele Provenzano, Pablo E. Pergola, Sydney C.W. Tang, Christoph Wanner, Philippe Zaoui, Hans-Henrik Parving, Dick de Zeeuw and Hiddo J.L. Heerspink
Pubblicato in: Journal of the American Society of Nephrology, Numero 32 (11), 2021, Pagina/e 2731-2734, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021040498

Clonal Hematopoiesis of Indeterminate Potential and Diabetic Kidney Disease: A Nested Case-Control Study.

Autori: Sara Denicolò, Verena Vogi, Felix Keller, Stefanie Thöni, Susanne Eder, Hiddo J.L. Heerspink , László Rosivall, Andrzej Wiecek, Patrick B. Mark, Paul Perco, Johannes Leierer, Andreas Kronbichler, Marion Steger, Simon Schwendinger, Johannes Zschocke, Gert Mayer, Emina Jukic
Pubblicato in: Kidney International Reports, Numero 24680249, 2022, Pagina/e 876-888, ISSN 2468-0249
Editore: Elsevier
DOI: 10.1016/j.ekir.2022.01.1064

Inhibition of Lysine 63 ubiquitination prevents the progression of renal fibrosis in diabetic DBA/2J mice.

Autori: Paola Pontrelli, Francesca Conserva, Rossella Menghini, Michele Rossini, Alessandra Stasi, Chiara Divella, Viviana Casagrande, Claudia Cinefra, Mariagrazia Barozzino, Simona Simone, Francesco Pesce, Giuseppe Castellano, Giovanni Stallone, Anna Gallone, Francesco Giorgino, Massimo Federici and Loreto Gesualdo
Pubblicato in: International Journal of Molecular Sciences, Numero 14220067, 2021, Pagina/e 5194, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105194

The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study

Autori: Simona Hapca, Moneeza K. Siddiqui, Ryan S.Y. Kwan, Michelle Lim, Shona Matthew, Alex S.F. Doney, Ewan R. Pearson, Colin N.A. Palmer, Samira Bell
Pubblicato in: Journal of the American Society of Nephrology, Numero 32/1, 2020, Pagina/e 138-150, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2020030323

A reciprocal regulation of spermidine and autophagy in podocytes maintains the filtration barrier

Autori: Wei Liang, Kosuke Yamahara, Camila Hernando-Erhard, Simon Lagies, Nicola Wanner, Huan Liang, Christoph Schell, Bernd Kammerer, Tobias B. Huber, Tillmann Bork
Pubblicato in: Kidney International, Numero 98/6, 2020, Pagina/e 1434-1448, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2020.06.016

An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles.

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Increased rejection rates in kidney transplantations during the COVID-19 pandemic

Autori: Schmidt-Lauber C, Spoden M, Huber TB, Günster C, Grahammer F.
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Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs

Autori: Francesca Solagna, Caterina Tezze, Maja T. Lindenmeyer, Shun Lu, Guochao Wu, Shuya Liu, Yu Zhao, Robert Mitchell, Charlotte Meyer, Saleh Omairi, Temel Kilic, Andrea Paolini, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Dominik Kylies, Julian Schulze zur Wiesch, Jan-Eric Turner, Nicola Wanner, Viji Nair, Felix Eichinger, Rajasree Menon, Ina V. Martin, Barbara M. Klinkhammer, Elion Hoxha, Clemen
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mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

Autori: Victor G. Puelles, James W. van der Wolde, Nicola Wanner, Markus W. Scheppach, Luise A. Cullen-McEwen, Tillmann Bork, Maja T. Lindenmeyer, Lukas Gernhold, Milagros N. Wong, Fabian Braun, Clemens D. Cohen, Michelle M. Kett, Christoph Kuppe, Rafael Kramann, Turgay Saritas, Claudia R. van Roeyen, Marcus J. Moeller, Leon Tribolet, Richard Rebello, Yu B.Y. Sun, Jinhua Li, Gerard Müller-Newen, Michael
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Bias and Precision in Magnetic Resonance Imaging-Based Estimates of Renal Blood Flow: Assessment by Triangulation

Autori: Bashair A. Alhummiany, David Shelley, Margaret Saysell, Maria-Alexandra Olaru, Bernd Kühn P, David L. Buckley, Julie Bailey, Kelly Wroe, Cherry Coupland, Michael W. Mansfield, Steven P. Sourbron, Kanishka Sharma
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Precision medicine in regulatory decision making: Biomarkers used for patient selection in European Public Assessment Reports from 2018 to 2020

Autori: Elisabeth Bakker, Viktoriia Starokozhko, Jet W M Kraaijvanger, Hiddo J L Heerspink, Peter G M Mol
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Consensus-based technical recommendations for clinical translation of renal ASL MRI

Autori: Fabio Nery, Charlotte E. Buchanan, Anita A. Harteveld, Aghogho Odudu, Octavia Bane, Eleanor F. Cox, Katja Derlin, H. Michael Gach, Xavier Golay, Marcel Gutberlet, Christoffer Laustsen, Alexandra Ljimani, Ananth J. Madhuranthakam, Ivan Pedrosa, Pottumarthi V. Prasad, Philip M. Robson, Kanishka Sharma, Steven Sourbron, Manuel Taso, David L. Thomas, Danny J. J. Wang, Jeff L. Zhang, David C. Alsop, Se
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Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Autori: Alexandra Ljimani, Anna Caroli, Christoffer Laustsen, Susan Francis, Iosif Alexandru Mendichovszky, Octavia Bane, Fabio Nery, Kanishka Sharma, Andreas Pohlmann, Ilona A. Dekkers, Jean-Paul Vallee, Katja Derlin, Mike Notohamiprodjo, Ruth P. Lim, Stefano Palmucci, Suraj D. Serai, Joao Periquito, Zhen Jane Wang, Martijn Froeling, Harriet C. Thoeny, Pottumarthi Prasad, Moritz Schneider, Thoralf Niendo
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Should we enlarge the indication for kidney biopsy in patients with diabetes? The pro part.

Autori: Loreto Gesualdo, Marco Fiorentino, Francesca Conserva, Paola Pontrelli
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SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance

Autori: Manuel Rogg, Jasmin I. Maier, Robert Dotzauer, Nadine Artelt, Oliver Kretz, Martin Helmstädter, Ahmed Abed, Alena Sammarco, August Sigle, Dominik Sellung, Patrick Dinse, Karoline Reiche, Mako Yasuda-Yamahara, Martin L. Biniossek, Gerd Walz, Martin Werner, Nicole Endlich, Oliver Schilling, Tobias B. Huber, Christoph Schell
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Initiation of the SGLT2 inhibitor canagliflozin to prevent kidney and cardiovascular outcomes guided by HbA1c, albuminuria, and predicted risk of kidney failure

Autori: Sok Cin Tye, Niels Jongs, Steven G. Coca, Johan Sundström, Clare Arnott, Bruce Neal, Vlado Perkovic, Kenneth W. Mahafey, Priya Vart and Hiddo. J. L. Heerspink
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Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes

Autori: Taha Sen, Wenjun Ju, Viji Nair, Patricia Ladd, Rajasree Menon, Edgar A Otto, Laura Pyle, Tim Vigers, Robert G Nelson, Clare Arnott, Bruce Neal, Michael K Hansen, Matthias Kretzler, Petter Bjornstad, Hiddo J L Heerspink
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Mechanisms of action of the sodium-glucose cotransporter-2 (SGLT2) inhibitor canagliflozin on tubular inflammation and damage: A post hoc mediation analysis of the CANVAS trial

Autori: Taha Sen, Akihiko Koshino, Bruce Neal, Maarten J. Bijlsma, Clare Arnott, Jingwei Li, Michael K. Hansen, Joachim H. Ix, Hiddo J. L. Heerspink
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Association between TNF Receptors and KIM-1 with Kidney Outcomes in Early-Stage Diabetic Kidney Disease

Autori: Simke W. Waijer, Taha Sen, Clare Arnott, Bruce Neal, Jos G.W. Kosterink, Kenneth W. Mahaffey, Chirag R. Parikh, Dick de Zeeuw, Vlado Perkovic, Brendon L. Neuen, Steven G. Coca, Michael K. Hansen, Ron T. Gansevoort and Hiddo J.L. Heerspink
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Comparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease

Autori: Karina Barreiro, Om Prakash Dwivedi, German Leparc, Marcel Rolser, Denis Delic, Carol Forsblom, Per-Henrik Groop, Leif Groop, Tobias B. Huber, Maija Puhka, Harry Holthofer
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An integrated organoid omics map extends modeling potential of kidney disease

Autori: Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria
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Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

Autori: Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton,James W. Dear, Juan M. Falcón-Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge
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Editore: Taylor & Francis Group
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A metabolomics‐based molecular pathway analysis of how the sodium‐glucose co‐transporter‐2 inhibitor dapagliflozin may slow kidney function decline in patients with diabetes

Autori: Skander Mulder, Ann Hammarstedt, Sunil B. Nagaraj, Viji Nair, Wenjun Ju, Jonatan Hedberg, Peter J. Greasley, Jan W. Eriksson, Jan Oscarsson, Hiddo J. L. Heerspink
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Recent advances in drug discovery for diabetic kidney disease

Autori: Chhanda Charan Danta, Andrew N. Boa, Sunil Bhandari, Thozhukat Sathyapalan, Shang-Zhong Xu
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Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy.

Autori: Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F.
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A prediction model for the decline in renal function in people with type 2 diabetes mellitus: study protocol

Autori: Mariella Gregorich, Andreas Heinzel, Michael Kammer, Heike Meiselbach, Carsten A. Böger, Kai-Uwe Eckardt, Gert Mayer, Georg Heinze, Rainer Oberbauer
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Primary decidual zone formation requires Scribble for pregnancy success in mice

Autori: Jia Yuan, Shizu Aikawa, Wenbo Deng, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B. Huber, Xiaofei Sun, Sudhansu K. Dey
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
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Renal vascular resistance is increased in patients with kidney transplant

Autori: Johanna Päivärinta, Vesa Oikonen, Anne Räisänen-Sokolowski, Tuula Tolvanen, Eliisa Löyttyniemi, Hidehiro Iida, Pirjo Nuutila, Kaj Metsärinne, Niina Koivuviita
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Special issue on magnetic resonance imaging biomarkers of renal disease

Autori: Paul Hockings, Christoffer Laustsen, Jaap A. Joles, Patrick B. Mark, Steven Sourbron
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Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine

Autori: Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulça Uluvar, Matthias Wuttke, Yurong Cheng, Arif B. Ekici, Gergely Gyimesi, Edward D Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F Gomez, Bing Yu, Morgan E Grams, Josef Coresh, Eric Boerwinkle, Michael Köttgen, Florian Kronenberg, Heike Meiselbach, Robert P Mohney, Shreeram A
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Different roles of protein biomarkers predicting eGFR trajectories in people with chronic kidney disease and diabetes mellitus: a nationwide retrospective cohort study

Autori: Michael Kammer, Andreas Heinzel, Karin Hu, Heike Meiselbach, Mariella Gregorich, Martin Busch, Kevin L Duffin, Maria F Gomez, Kai-Uwe Eckardt, Rainer Oberbauer, BEAt-DKD consortium
Pubblicato in: Cardiovascular Diabetology, Numero Mar 29;22(1), 2023, Pagina/e 74, ISSN 1475-2840
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The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier

Autori: Christoph Schell, Manuel Rogg, Martina Suhm, Martin Helmstädter, Dominik Sellung, Mako Yasuda-Yamahara, Oliver Kretz, Victoria Küttner, Hani Suleiman, Laxmikanth Kollipara, René P. Zahedi, Albert Sickmann, Stefan Eimer, Andrey S. Shaw, Albrecht Kramer-Zucker, Mariko Hirano-Kobayashi, Takaya Abe, Shinichi Aizawa, Florian Grahammer, Björn Hartleben, Jörn Dengjel, Tobias B. Huber
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/23, 2017, Pagina/e E4621-E4630, ISSN 0027-8424
Editore: National Academy of Sciences
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YAP-mediated mechanotransduction determines the podocyte’s response to damage

Autori: Markus M. Rinschen, Florian Grahammer, Ann-Kathrin Hoppe, Priyanka Kohli, Henning Hagmann, Oliver Kretz, Sabine Bertsch, Martin Höhne, Heike Göbel, Malte P. Bartram, Rajesh Kumar Gandhirajan, Marcus Krüger, Paul-Thomas Brinkkoetter, Tobias B. Huber, Martin Kann, Sara A. Wickström, Thomas Benzing, Bernhard Schermer
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Targeting mTOR Signaling Can Prevent the Progression of FSGS

Autori: Stefan Zschiedrich, Tillmann Bork, Wei Liang, Nicola Wanner, Kristina Eulenbruch, Stefan Munder, Björn Hartleben, Oliver Kretz, Simon Gerber, Matias Simons, Amandine Viau, Martine Burtin, Changli Wei, Jochen Reiser, Nadja Herbach, Maria-Pia Rastaldi, Clemens D Cohen, Pierre-Louis Tharaux, Fabiola Terzi, Gerd Walz, Markus Gödel, Tobias B Huber
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Renal trials in diabetes need a platform: time for a global approach?

Autori: Dick de Zeeuw, Hiddo J L Heerspink, Meg Jardine, Vlado Perkovic
Pubblicato in: The Lancet Diabetes & Endocrinology, Numero 6/5, 2018, Pagina/e 356-358, ISSN 2213-8587
Editore: Elsevier BV
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The Evolving Complexity of the Podocyte Cytoskeleton

Autori: Christoph Schell, Tobias B. Huber
Pubblicato in: Journal of the American Society of Nephrology, Numero 28/11, 2017, Pagina/e 3166-3174, ISSN 1046-6673
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ORAI channels are critical for receptor-mediated endocytosis of albumin

Autori: Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez, Shang-Zhong Xu
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DOI: 10.1038/s41467-017-02094-y

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton

Autori: Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. Völker, Eva-Maria Schurek, Julie Binz, Martin Höhne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, Thomas Benzing
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The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton

Autori: M. Rogg, M. Yasuda-Yamahara, A. Abed, P. Dinse, M. Helmstädter, A. C. Conzelmann, J. Frimmel, D. Sellung, M. L. Biniossek, O. Kretz, F. Grahammer, O. Schilling, T. B. Huber, C. Schell
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Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment

Autori: Luca Musante, Dorota Tataruch-Weinert, Dontscho Kerjaschki, Michael Henry, Paula Meleady, Harry Holthofer
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Using the Drosophila Nephrocyte to Model Podocyte Function and Disease

Autori: Martin Helmstädter, Tobias B. Huber, Tobias Hermle
Pubblicato in: Frontiers in Pediatrics, Numero 5, 2017, ISSN 2296-2360
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Renal biopsy-driven molecular target identification in glomerular disease

Autori: Maja T. Lindenmeyer, Matthias Kretzler
Pubblicato in: Pflügers Archiv - European Journal of Physiology, Numero 469/7-8, 2017, Pagina/e 1021-1028, ISSN 0031-6768
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Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

Autori: Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna Köttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wh
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Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

Autori: Carole Henique, Guillaume Bollée, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, Léa Guyonnet, François Gaillard, Hélène Lazareth, Charlotte Meyer, Imane Bensaada, Luc Legrès, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet, Dominique Nochy, Tobias B. Huber, Laurent Mesnard, Olivia Lenoir, Pierre-Lo
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FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology

Autori: M. Yasuda-Yamahara, M. Rogg, J. Frimmel, P. Trachte, M. Helmstaedter, P. Schroder, M. Schiffer, C. Schell, T.B. Huber
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Individual variability in response to renin angiotensin aldosterone system inhibition predicts cardiovascular outcome in patients with type 2 diabetes: A primary care cohort study

Autori: Ellen M. Apperloo, Michelle J. Pena, Dick de Zeeuw, Petra Denig, Hiddo J. L. Heerspink
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 20/6, 2018, Pagina/e 1377-1383, ISSN 1462-8902
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Single-nephron proteomes connect morphology and function in proteinuric kidney disease

Autori: Martin Höhne, Christian K. Frese, Florian Grahammer, Claudia Dafinger, Giuliano Ciarimboli, Linus Butt, Julia Binz, Matthias J. Hackl, Mahdieh Rahmatollahi, Martin Kann, Simon Schneider, Mehmet M. Altintas, Bernhard Schermer, Thomas Reinheckel, Heike Göbel, Jochen Reiser, Tobias B. Huber, Rafael Kramann, Tamina Seeger-Nukpezah, Max C. Liebau, Bodo B. Beck, Thomas Benzing, Andreas Beyer, Markus M
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Endogenous factors and mechanisms of renoprotection and renal repair

Autori: Paul Perco, Gert Mayer
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New clinical trial designs for establishing drug efficacy and safety in a precision medicine era

Autori: Hiddo J. L. Heerspink, James List, Vlado Perkovic
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 20, 2018, Pagina/e 14-18, ISSN 1462-8902
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Implementing personalized medicine in diabetic kidney disease: Stakeholders' perspectives

Autori: Jeroen K. de Vries, Adeera Levin, Fiona Loud, Amanda Adler, Gert Mayer, Michelle J. Pena
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 20, 2018, Pagina/e 24-29, ISSN 1462-8902
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Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Autori: Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
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Precision medicine in diabetes and diabetic kidney disease: Regulatory considerations

Autori: Peter G. M. Mol, Aliza Thompson, Hiddo J. L. Heerspink, Hubert G. M. Leufkens
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An integrative systems biology approach for precision medicine in diabetic kidney disease

Autori: Skander Mulder, Habib Hamidi, Matthias Kretzler, Wenjun Ju
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Treating diabetic complications; from large randomized clinical trials to precision medicine

Autori: Hiddo J. L. Heerspink, Dick de Zeeuw
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 20, 2018, Pagina/e 3-5, ISSN 1462-8902
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Molecular, histological, and clinical phenotyping of diabetic nephropathy: valuable complementary information?

Autori: Paul Perco, Gert Mayer
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Systems biology approaches to identify disease mechanisms and facilitate targeted therapy in the management of glomerular disease

Autori: Habib Hamidi, Matthias Kretzler
Pubblicato in: Current Opinion in Nephrology and Hypertension, 2018, Pagina/e 1, ISSN 1062-4821
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N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk

Autori: Nienke M. A. Idzerda, Frederik Persson, Michelle J. Pena, Barry M. Brenner, Patrick Brunel, Nish Chaturvedi, John J. McMurray, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J. L. Heerspink
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Novel avenues for drug discovery in diabetic kidney disease

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Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes

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Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

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A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes

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Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials

Autori: Nienke M A Idzerda, Michelle J Pena, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J L Heerspink
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Personalized medicine in diabetic kidney disease

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Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis

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Urinary extracellular vesicles. A promising shortcut to novel biomarker discoveries

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Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

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Autori: Marcos Wolf, Anneloes de Boer, Kanishka Sharma, Peter Boor, Tim Leiner, Gere Sunder-Plassmann, Ewald Moser, Anna Caroli, Neil Peter Jerome
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CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

Autori: Hans-Joachim Anders, Tobias B. Huber, Berend Isermann, Mario Schiffer
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Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

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AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes

Autori: Mako Yasuda-Yamahara, Manuel Rogg, Kosuke Yamahara, Jasmin I. Maier, Tobias B. Huber, Christoph Schell
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ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier

Autori: Christoph Schell, Benedikt Sabass, Martin Helmstaedter, Felix Geist, Ahmed Abed, Mako Yasuda-Yamahara, August Sigle, Jasmin I. Maier, Florian Grahammer, Florian Siegerist, Nadine Artelt, Nicole Endlich, Dontscho Kerjaschki, Hans-Henning Arnold, Jörn Dengjel, Manuel Rogg, Tobias B. Huber
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DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

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Multimarker Panels in Diabetic Kidney Disease: The Way to Improved Clinical Trial Design and Clinical Practice?

Autori: Paul Perco, Michelle Pena, Hiddo J.L. Heerspink, Gert Mayer
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The Evolving Importance of Insulin Signaling in Podocyte Health and Disease

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P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis

Autori: Laura Rennert, Stefan Zschiedrich, Lukas Sandner, Björn Hartleben, Sanja Cicko, Cemil Korcan Ayata, Charlotte Meyer, Andreas Zech, Robert Zeiser, Tobias B. Huber, Marco Idzko, Florian Grahammer
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Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress

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Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

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Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells

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Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease

Autori: Hiddo J. L. Heerspink, Paul Perco, Skander Mulder, Johannes Leierer, Michael K. Hansen, Andreas Heinzel, Gert Mayer
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Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers

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Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

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Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease

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Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles

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Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes

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Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes

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Management of Tamm–Horsfall Protein for Reliable Urinary Analytics

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Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy

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Estimated lifetime benefit of novel pharmacological therapies in patients with type 2 diabetes and chronic kidney disease: A joint analysis of randomized controlled clinical trials

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Metabolite Signature of Albuminuria Involves Amino Acid Pathways in 8661 Finnish Men Without Diabetes

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Elevated circulating follistatin associates with an increased risk of type 2 diabetes

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A protocol for rat kidney normothermic machine perfusion and subsequent transplantation

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BET Proteins Regulate Expression of Osr1 in Early Kidney Development

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Capturing the Kidney Transcriptome by Urinary Extracellular Vesicles—From Pre-Analytical Obstacles to Biomarker Research

Autori: Karina Barreiro, Om Prakash Dwivedi, Antti Rannikko, Harry Holthöfer, Tiinamaija Tuomi, Per-Henrik Groop, Maija Puhka
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Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells

Autori: Nawel Zaibi, Pengyun Li, Shang-Zhong Xu
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Deep learning–based molecular morphometrics for kidney biopsies

Autori: Marina Zimmermann, Martin Klaus, Milagros N. Wong, Ann-Katrin Thebille, Lukas Gernhold, Christoph Kuppe, Maurice Halder, Jennifer Kranz, Nicola Wanner, Fabian Braun, Sonia Wulf, Thorsten Wiech, Ulf Panzer, Christian F. Krebs, Elion Hoxha, Rafael Kramann, Tobias B. Huber, Stefan Bonn, Victor G. Puelles
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Biomarker Qualification at the European Medicines Agency: A Review of Biomarker Qualification Procedures From 2008 to 2020

Autori: Elisabeth Bakker, Natalie M Hendrikse, Falk Ehmann, Daniëlla S van der Meer, Jordi Llinares Garcia, Thorsten Vetter, Viktoriia Starokozhko, Peter G M Mol
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Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development

Autori: Fuhrmann L, Lindner S, Hauser AT, Höse C, Kretz O, Cohen CD, Lindenmeyer MT, Sippl W, Jung M, Huber TB, Wanner N
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The importance of targeting multiple risk markers in patients with type 2 diabetes: A post-hoc study from the CANVAS programme

Autori: SokCin Tye, Megumi Oshima, Clare Arnott, Brendon L. Neuen, Robert A. Fletcher, Bruce Neal, Hiddo J. L. Heerspink
Pubblicato in: Diabetes Obesity and Metabolism, Numero 2023;1–8, 2023, ISSN 1462-8902
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Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building Meeting

Autori: Elisabeth Bakker, Peter G. M. Mol, João Nabais, Thorsten Vetter, Matthias Kretzler, John J. Nolan, Gert Mayer, Anna K. Sundgren, Hiddo J. L. Heerspink, Anja Schiel, Sieta T. de Vries, Maria F. Gomez, Friedrich Schulze, Dick de Zeeuw, Michelle J. Pena
Pubblicato in: Frontiers in Pharmacology, 2021, ISSN 1663-9812
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Dichotomous responses to chronic fetal hypoxia lead to a predetermined aging phenotype

Autori: Rudloff S, Bileck A, Janker L, Wanner N, Liaukouskaya N, Lundby C, Huber TB, Gerner C, Huynh-Do U
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Urinary extracellular vesicles: Assessment of pre-analytical variables and development of a quality control with focus on transcriptomic biomarker research

Autori: Karina Barreiro, Om Prakash Dwivedi Sami Valkonen, Per-Henrik Groop, Tiinamaija Tuomi, Harry Holthofer, Antti Rannikko, Marjo Yliperttula Pia Siljander, Saara Laitinen, Elina Serkkola, Taija af Hällström, Carol Forsblom, Leif Groop, Maija Puhka
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Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

Autori: Michael Crompton; Joanne K. Ferguson; Raina D. Ramnath; Karen L. Onions; Anna S. Ogier; Monica Gamez; Colin J. Down; Laura Skinner; Kitty H. Wong; Lauren K. Dixon; Judit Sutak; Steven J. Harper; Paola Pontrelli; Loreto Gesualdo; Hiddo L. Heerspink; Robert D. Toto; Gavin I. Welsh; Rebecca R. Foster; Simon C. Satchell; Matthew J. Butler
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Organic Anion Transporter Gene Variants Associated with Plasma Exposure and Long-Term Response to Atrasentan in Patients With Diabetic Kidney Disease

Autori: J. David Smeijer, Jeroen V. Koomen, Donald E. Kohan, John J. V. McMurray, George L. Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, Dalane W. Kitzman, Hirofumi Makino, Gert Mayer, Michal Nowicki, Vlado Perkovic, Peter Rossing, Sheldon Tobe, Hans-Henrik Parving, Dick de Zeeuw and Hiddo J. L. Heerspink
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Renal Perfusion, Oxygenation and Metabolism: The Role of Imaging

Autori: Johanna Päivärinta, Ioanna A Anastasiou, Niina Koivuviita, Kanishka Sharma, Pirjo Nuutila, Ele Ferrannini, Anna Solini, Eleni Rebelos
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VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney

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Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure

Autori: J. David Smeijer, Jeroen Koomen, Donald E. Kohan, John J.V. McMurray, George L. Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, James L. Januzzi, Dalane W. Kitzman, Daniel M. Kolansky, Hirofumi Makino, Vlado Perkovic, Sheldon Tobe, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J.L. Heerspink
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Kidney outcome after mild to moderate COVID-19.

Autori: Christian Schmidt-Lauber, Sonja Hänzelmann, Stefan Schunk, Elina L Petersen, Ammar Alabdo, Maja Lindenmeyer, Fabian Hausmann, Piotr Kuta, Thomas Renné, Raphael Twerenbold, Tanja Zeller, Stefan Blankenberg, Danilo Fliser, Tobias B Huber
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Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL

Autori: Nienke M. A. Idzerda, Lindsay E. Clegg, Adrian F. Hernandez, George Bakris, Robert C. Penland, David W. Boulton, M. Angelyn Bethel, Rury R. Holman, Hiddo J. L. Heerspink
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IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

Autori: Abigail C. Lay, Lorna J. Hale, Holly Stowell-Connolly, Robert J. P. Pope, Viji Nair, Wenjun Ju, Eva Marquez, Ruth Rollason, Jenny A. Hurcombe, Bryony Hayes, Timothy Roberts, Lawrence Gillam, Jonathan Allington, Robert G. Nelson, Matthias Kretzler, Jeff M. P. Holly, Claire M. Perks, Craig A. McArdle, Gavin I. Welsh, Richard J. M. Coward
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The future of Diabetic Kidney Disease management: reducing the unmet need

Autori: Dick de Zeeuw
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Better prediction of drug response in diabetic kidney disease: a biomarker approach to personalize therapy

Autori: Nienke Idzerda
Pubblicato in: 2020
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Urinary extracellular vesicles in diabetic kidney disease: ASSESSMENT OF PRE-ANALYTICAL VARIABLES AND IDENTIFICATION OF NOVEL CANDIDATE MARKERS

Autori: Karina Barreiro
Pubblicato in: 2023, ISBN 978-951-51-9201-1
Editore: Helsingin yliopisto

Urinary Extracellular Vesicles Magic Particles for Biomarker Discovery

Autori: Karina Barreiro, Tobias B Huber, Harry Holthofer
Pubblicato in: Translational Urinomics, Numero Advances in Experimental Medicine and Biology, vol 1306, 2021, ISBN 978-3-030-63908-2
Editore: Springer, Cham
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