Objectif Infection remains an important cause of morbidity and mortality in neonates. We have established that MBL defects can influnce the rate of infection in this patient population. Therefore if we understood more about importance and mechanisms of this MBL dys function we could potentially modify our approach to managing neonatal infection. This project is a logical extension of work performed while I was a Marie Curie Individual Reseach Fellow. The basis of this project stems from recent work which shows that c omplement activating capacity of MBL is related to levels of MASP-2, an MBL associated serine protease. The proposed study will explore the relationship between MASP-2 activity and susceptibility to infection. This work will be complemented by genetic stud ies relating MASP-2 genotype and MASP-2 levels. The results of this project will directly inform on the role of MBL- MASP in neonatal susceptibility to infection. In addition it will allow me to reintegrate back to Poland and facilitate two way scientific interactions between Poland and the UK. Champ scientifique social sciencessociologydemographymortalitynatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicineoncology Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-4.1 - Marie Curie European Reintegration Grants (ERG) Appel à propositions FP6-2002-MOBILITY-11 Voir d’autres projets de cet appel Régime de financement ERG - Marie Curie actions-European Re-integration Grants Coordinateur POLISH MOTHERS MEMORIAL HOSPITAL- RESEARCH INSTITUTE Contribution de l’UE Aucune donnée Adresse Rzgowska 281/ 289 Street LODZ Pologne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
