Objective
Tuberculosis is a major public health problem. One third of the world population is estimated to carry latent infections and the global incidence of TB increases by 2% annually. An additional major problem is the increasing incidence of
multi-drug resistances (MDR) in Eastern Europe. Such a situation will require new types of intervention and a much better follow up on the TB patients. The goal of this project is to develop and design new markers of protection and to identify
unique molecular patterns both in the microbe and in the host cells, associated with early interactions between M. tuberculosis and phagocytic cells.
Comparative genomics offers a highly innovative opportunity to decipher M. tuberculosis interactions with the immune system, using transcriptional profiling approaches. In particular, early interactions between M. tuberculosis and host phagocytes, namely macrophages (Mf) and dendritic cells (DC), are thought to play a crucial role in mounting a protective immune response, and in determining the outcome of infection. Microarrays will be used to simultaneously study the entire expressed genomes of both the mammalian host and the microbial parasite during their interaction. Data analysis of the M. tuberculosis arrays, developed by the participants, will reveal patterns of the induced gene expression and most likely, unique novel targets for vaccine design. Data analysis of human arrays (GeneChips by Affymetrix) of M. tuberculosis infected monocytes and dendritic cells will allow us to identify molecular markers and pathways associated with protection. This project fully integrates the activities of internationally recognized groups that have pioneered immuno-genomics of DC and Mf with groups that have developed the TB field and M. tuberculosis arrays.
These groups will provide a new European resource, a transcriptional TB database, a key tool for the identification of new molecular markers and targets.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.