Ziel
The scope of the project can be located at the intersection between nano- and biomaterial sciences and magnet technology. The overall objective is to manufacture and then utilise smart magnetic materials in new production processes in order to produce even smarter products for the biomaterials, food and biopharmaceuticals sector. The first step is the manufacture of multifunctional magnetic materials (4M) that will serve as smart tools for new processes to be developed in a second step. The new materials will integrate magnetic properties with additional material properties that are required by their related processes, e.g. nano properties and high specific adsorption surface areas, highly selective affinity interaction properties, site-selective adsorptio n properties and chemical modification properties, biocompatibility and corrosion-resistance. The new processing technologies to be developed are broadly divided into two research efforts,i.e. those for BIOSEPARATION and BIOSYNTHESIS. The BIOSEPARATIONS effort includes the development of new smart magnetic extraction phases (SMEPs) and the development of novel magnetically enhanced centrifugation processes (MEC). Both efforts target todays major problem in pharmaceutical bioseparations, i.e. that processe s are slow, multi-step, low-yield, non-integrated, and thus very costly. The BIOSYNTHESIS effort includes the development of a new magnetic structuring process (NABIS) that allows the defined assembly and crystallisation of macromolecules in a combined mag netic and shear field. The second biosynthesis effort targets the assembly of totally new macromolecule constructs (CUSS) that are not producible by conventional cell factories. The goal is to use smart support materials to modify proteins, e.g. by directe d site-selective PEGylation. With the aid of click chemistry this approach may be extended to assemble nano-constructs, e.g. nano-motors or nano-machines.
Wissenschaftliches Gebiet
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- engineering and technologymaterials engineeringcoating and films
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
- engineering and technologynanotechnologynano-materials
- engineering and technologyindustrial biotechnologybiomaterials
Schlüsselbegriffe
Thema/Themen
Aufforderung zur Vorschlagseinreichung
FP6-2003-NMP-TI-3-MAIN
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