A multi-scale modeling study is proposed to develop a fundamental understanding of the segregation and self assembly of phospholipids and polypeptide amphiphiles at interfaces, and their interaction with liquid crystalline phases. The current study is moti vated by recent experiments that indicate that liquid crystalline phases are capable of interrogating the structure of phospholipidic interfaces at the scale of nanometers, thereby providing a powerful tool for probing nanoscale structure, and providing th e basis for development of sensors for biological molecules. This study is also motivated by experiments from the Stupp group that indicate that peptide amphiphile molecules self-assemble into highly organized structures whose interfaces provide an ideal s ubstrate for cell growth.
Fields of science
- natural sciencesphysical sciencesthermodynamics
- natural sciencesphysical sciencescondensed matter physicssoft matter physics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencescomputer and information sciencescomputational sciencemultiphysics
- engineering and technologymaterials engineeringliquid crystals
- FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006.
Call for proposal
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