Obiettivo
A multi-scale modeling study is proposed to develop a fundamental understanding of the segregation and self assembly of phospholipids and polypeptide amphiphiles at interfaces, and their interaction with liquid crystalline phases. The current study is moti vated by recent experiments that indicate that liquid crystalline phases are capable of interrogating the structure of phospholipidic interfaces at the scale of nanometers, thereby providing a powerful tool for probing nanoscale structure, and providing th e basis for development of sensors for biological molecules. This study is also motivated by experiments from the Stupp group that indicate that peptide amphiphile molecules self-assemble into highly organized structures whose interfaces provide an ideal s ubstrate for cell growth.
Campo scientifico
- natural sciencesphysical sciencesthermodynamics
- natural sciencesphysical sciencescondensed matter physicssoft matter physics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencescomputer and information sciencescomputational sciencemultiphysics
- engineering and technologymaterials engineeringliquid crystals
Parole chiave
Invito a presentare proposte
FP6-2004-NMP-NSF-1
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Meccanismo di finanziamento
STREP - Specific Targeted Research ProjectCoordinatore
MADRID
Spagna