Objective
Biofilms are communities of cells attached to an abiotic surface that are enclosed within a glycocalyx. They cause significant health care problems, since they form on implants, stents and catheters, and lead to obstruction and chronic or recurring infect ions that often are recalcitrant to treatment with antimicrobials. This has a negative impact on the well-being of the patient, and results in a rise in health care costs.
A major goal must therefore be to develop methods to prevent biofilm formation, which can be achieved more readily if we understand the process fully. This project aims to identify factors that contribute to bacterial biofilm formation, maintenance and dispersal, and will focus specifically on catheter related urinary tract infections (CAUTI). CAUTI are among the most prevalent nosocomial infections, especially in geriatric and urological wards and thus will increase in significance with the increase in life expectancy. The two specific objectives of this proposal are to examine whether there are biofilm specific genes, and to identify genes that are required for either biofilm maturation or dispersal.
The objectives will be achieved using the recombinase-based in vivo expression technology (RIVET) method that we will be introducing to the biofilm field, but that has been successful in analysing host-pathogen interactions. This method, which consists of a sensitive, genome wide genetic screen for promoter activity, has specific advantages. This includes documentation of gene expression that occurs in only a small percentage of the population, and also of expression that occurs only transiently. Both aspects are important due to the heterogeneous, changing nature of the biofilm.
To summarize, the project introduces to this field a broadly applicable method that complements current approaches, will help establish the applicantions research program in the EU, and is likely to provide new insights into biofilm formation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine urology
- medical and health sciences medical biotechnology implants
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
YORK
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.