Objective
22,750,000 dyslexic individuals, including 2,500,000 dyslexic school children in the EC have a specific disorder in learning to read and spell (dyslexia). Since dyslexia occurs in all languages and presents a lifelong burden characterized by academic failure, poor school attendance, problems with social adjustments and unemployment. So far the etiology of dyslexia is poorly understood. Therefore, it is mandatory to tackle the problem from sev-eral directions. In a multicentre, multidisciplinary project we will investigate the biological basis of dyslexia by collecting pow-erful samples of subjects consistently characterised across EC populations on three different levels: genetics, environment, and neuroscience. Our aim is to understand the etiology of the disorder by integrating the results of the three levels. On the genetic level, we will use a systematic two stage approach to map and clone dyslexia susceptibility genes in samples of 800 families and 2000 dyslexic cases and 2000 controls. The identified risk-conferring genes will also be used to understand gene-gene and gene-environment interactions, as well as gene-specific contributions to a variety of neurobiological correlates of dyslexia. Environmental risk factors will be investigated in two samples, a longitudinal sample of 4000 twin pairs and a longitudinal sample of 100 at-risk and 100 non at-risk children. On the neuroscience level (structural and functional brain studies including cutting edge technology such as effective connectivity) we will investigate the prerequisites of reading and spelling development and the central stages of becoming a fluent reader. The resulting research group will be a high quality, adaptive and cooperative European consortium composed of psychologists, molecular biologists/geneticists, clinicians and genetic statisticians. With these combined efforts we are confident to improve the basis for the development of successful diagnostics and therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences computer and information sciences databases
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences health care services
- social sciences sociology social issues unemployment
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MÜNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.