EDGE MULTI SENSING FOR MEDICAL AND PHARMA APPLICATIONS

Projektinformationen

DETERMINATION

ID Finanzhilfevereinbarung: 190123677

DOI

10.3030/190123677

Projekt abgeschlossen

EK-Unterschriftsdatum 19 Dezember 2022

Startdatum 1 November 2022

Enddatum 31 Oktober 2024

Finanziert unter

• The European Innovation Council (EIC)

Gesamtkosten

€ 3 655 312,00

EU-Beitrag

€ 2 500 000,00

Koordiniert durch

EZMEMS LTD.
Israel

Periodic Reporting for period 2 - DETERMINATION (EDGE MULTI SENSING FOR MEDICAL AND PHARMA APPLICATIONS)

Berichtszeitraum: 2023-11-01 bis 2024-10-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Today's demanding medical treatment and pharmaceutical production require careful control of fluidic process conditions. This includes tasks like accurate feedback on the respiratory status of the patient, detecting occlusions during infusions, process monitoring during cell culture, purification, or drug product formulation, etc. The key enabling technology to digitize such tasks is to have cost-efficient multi-sensing capabilities at the most critical edge point of the process. The currently used medical/pharma systems lack sensing capabilities as sensors are expensive to integrate, generally sense only one physical parameter, are bulky, with a big environmental footprint, need an electrical power source, and cannot provide wireless power transmission and multisensing at the edge. Multi-sensing at the edge offers new opportunities to develop intelligent monitoring networks in hospitals and pharma manufacturing to provide fast and accurate responses saving costs and also lowering the environmental footprint at the time of sensors manufacturing.
EZMEMS provides DETERMINATION, a ‘Smart Disposable multisensor' that transform simple medical or biotech products (infusion lines, fittings, plastic bags, bioreactor, transportation line) into 'Smart products' in an easy and cost-effective way. The multisensor is non-invasive, has low footprint, and provides robust multi-sensing (pressure, flow, temperature, conductivity, turbidity and pH) and can even have fully wireless connectivity (no battery, no wires, energy harvesting) at the edge. EZMEMS' multisensor technology is based on advanced polymeric multi-layered matrix composite structure integrating micro electro mechanical (MEMS) elements. DETERMINATION can be fabricated in mass production facilities.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

EZMEMS has pioneered a groundbreaking technology for the production of polymeric chips capable of measuring multiple parameters within a single chip, a concept we refer to as a "multisensor." At present, our cutting-edge chip has the capacity to assess six key parameters: pressure, flow, temperature, turbidity, conductivity, and pH. This integration of diverse parameters takes place at the chip level, resulting in a reduced physical footprint, cost efficiency, and seamless integration at pivotal points within various processes, particularly at the process edges. The chip can be effortlessly incorporated into plastic components through conventional plastic integration techniques.

Beyond the multisensor itself, EZMEMS has developed a comprehensive infrastructure for powering, extracting, and visualizing data collected by the multisensor. This constitutes a holistic IoT (Internet of Things) solution, encompassing data acquisition from the edge and its transmission to the cloud.

To validate the effectiveness of our multisensor, we have conducted meticulous performance assessments. These evaluations involve a comparison with data acquired from six standard industrial sensors, each costing approximately 20,000 EUR. The tests are conducted using a dedicated testing apparatus capable of simulating various process conditions. These initial tests serve as a precursor to our ongoing field tests, which are designed to ascertain the multisensor's robust performance across diverse real-world scenarios.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

Since COVID-19 at the latest, it has been known that vaccination batches can show large differences since quality control is still challenging. Until now, getting the status of vaccines or other liquids in large or small containers means taking samples. Another challenge is to ensure the consistent quality of drugs or any other liquids that are added to the production process. EZMEMS is a developer of high-performance multi-sensing technology in a plastic chip for direct integration to read liquids’ statuses in real-time. EZMEMS’ solution helps customers to ensure the reliable quality and safety of pharmaceutical products.
In order to boost the impact, we need more financial resources (an investment) to increase the team and support all the tests that are now being discussed with large pharma companies that are excited to try our sensors.

EZMEMS’ multisensor for fluidic applications. The sensor can simultaneously measure 6 parameters.

EZMEMS’ multisensor configured into a fluidic application.