The SEB project was structured into five main work packages (WPs), each with clearly defined objectives and deliverables aimed at scaling Core Biogenesis’s plant-based bioproduction platform from prototype to industrial readiness. Below is a summary of the work performed and results achieved per work package.
WP1 – Development and Characterization of Transgenic Strains
Objective: Engineer high-yielding Camelina sativa strains expressing four key recombinant growth factors: Activin A, FGF-2, HSA, and TGF-β.
D1.1 (D1): A generic platform strain incorporating Core Biogenesis’s proprietary yield-enhancing genetic elements was developed and optimized. A seed master was established for this foundational strain.
D1.2 (D2): Seed master banks were successfully created for each of the four GF-specific strains following cross-breeding strategies.
D1.3 (D3): Expression levels and bioactivity of each GF were quantified, confirming successful production and biological functionality in the transgenic plants.
Milestones achieved as planned.
WP2 – Agronomic Optimization and Biomass Production
Objective: Develop scalable, high-yield greenhouse and field protocols to generate biomass from engineered strains.
D2.1 (D4): Validated 3 kg-scale greenhouse cultivation protocols for each strain, ensuring controlled and reproducible growth conditions.
D2.2 (D5): Best-performing lines for each GF were identified based on growth behavior, protein yield, and expression stability.
D2.3 (D6): Optimized and consolidated seed banks were produced for scale-up activities.
Successful greenhouse scale-up established; strain selection finalized without major deviation.
WP3 – Downstream Processing & Quality Control
Objective: Develop robust downstream processes for extraction, purification, and quality control of the growth factors.
D3.1 (D7): Standardized protocols for extraction from plant biomass were developed, focusing on recovery efficiency and scalability.
D3.2 (D8): Purification protocols were optimized to yield high-purity growth factors compatible with regulatory and market requirements.
D3.3 (D9): Analytical quality control workflows were designed and validated, including activity assays and impurity profiling.
Core purification workflows validated; QC procedures set up to support GMP-readiness.
WP4 – Communication, Dissemination & Business Development
Objective: Establish market visibility, strategic positioning, and commercial readiness.
D4.1 (D10): Dissemination and communication activities were documented, including media outreach, presentations, and early partnership conversations.
D4.2 (D11): A full market scoping exercise was completed, with updated competitor mapping and stakeholder engagement across biotech, foodtech, and cosmetics.
D4.3 (D12): A comprehensive and updated business plan was delivered, incorporating go-to-market strategy, pricing models, and IP positioning.
Clear traction observed in B2B interest and market alignment.
WP5 – Project Management
Objective: Ensure efficient project coordination and compliance.
D5.2 (D14): This final report includes the final data management plan and overall project closure documentation.
Project executed on time and within scope.
